Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Stem cell renewal and differentiation in cancer
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My laboratory studies biological mechanisms associated with tumor growth, with an emphasis on the regulation of the balance between stem cell renewal (maintains cells with long-term growth potential) and their differentiation into non-dividing progeny (dead-end for further growth).
We use mouse skin and oral epithelia to model squamous cell carcinoma, a common, aggressive, and largely incurable tumor that affects skin, head and neck tissues, and the lung.