Research Summary
My laboratory studies biological mechanisms associated with tumor growth, with an emphasis on the regulation of the balance between stem cell renewal (maintains cells with long-term growth potential) and their differentiation into non-dividing progeny (dead-end for further growth).
We use mouse skin and oral epithelia to model squamous cell carcinoma, a common, aggressive, and largely incurable tumor that affects skin, head and neck tissues, and the lung. We also use mouse mammary epithelium in studies of genetic basis of breast cancer.
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Publications
The following publications were retrieved from PubMed:
Hair follicle regeneration suppresses Ras-driven oncogenic growth.
Pineda CM, Gonzalez DG, Matte-Martone C, Boucher J, Lathrop E, Gallini S, Fons NR, Xin T, Tai K, Marsh E, Nguyen DX, Suozzi KC, Beronja S, Greco V.
J Cell Biol. 2019 Oct 7; 10(218)3212-3222
The androgen receptor regulates a druggable translational regulon in advanced prostate cancer.
Liu Y, Horn JL, Banda K, Goodman AZ, Lim Y, Jana S, Arora S, Germanos AA, Wen L, Hardin WR, Yang YC, Coleman IM, Tharakan RG, Cai EY, Uo T, Pillai SPS, Corey E, Morrissey C, Chen Y, Carver BS, Plymate SR, Beronja S, Nelson PS, Hsieh AC.
Sci Transl Med. 2019 Jul 31; 503(11)
