John Lee

Research Summary

We employ cutting-edge technologies including mouse and human prostate epithelial transformation systems; functional genomics; multi-omic data integration; high-throughput screening; small molecule drug discovery; and immuno-oncology to develop new approaches to stratify and treat prostate cancer. Current research projects include the functional characterization of drivers of aggressive prostate cancer, immunotherapeutic targeting of prostate cancer differentiation-specific antigens, and disruption of the protein stability of Myc and androgen receptor in advanced prostate cancer.