John Lee
jklee5@fredhutch.orgFred Hutch,
Cancer Biology
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
PROSTATE CANCER BIOLOGY
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
Reprogramming normal human epithelial tissues to a common, lethal neuroendocrine cancer lineage.
Park JW, Lee JK, Sheu KM, Wang L, Balanis NG, Nguyen K, Smith BA, Cheng C, Tsai BL, Cheng D, Huang J, Kurdistani SK, Graeber TG, Witte ON.
Science (New York, N.Y.). 2018; 362(6410):91-95.
- PMID:
- 30287662
Lee JK, Bangayan NJ, Chai T, Smith BA, Pariva TE, Yun S, Vashisht A, Zhang Q, Park JW, Corey E, Huang J, Graeber TG, Wohlschlegel J, Witte ON.
Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(19):E4473-E4482.
- PMID:
- 29686080
- PMCID:
- PMC5949005
FOXA2 is a sensitive and specific marker for small cell neuroendocrine carcinoma of the prostate.
Park JW, Lee JK, Witte ON, Huang J.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2017; 30(9):1262-1272. NIHMSID: NIHMS1516426
- PMID:
- 28621319
- PMCID:
- PMC6330177
Stoyanova T, Riedinger M, Lin S, Faltermeier CM, Smith BA, Zhang KX, Going CC, Goldstein AS, Lee JK, Drake JM, Rice MA, Hsu EC, Nowroozizadeh B, Castor B, Orellana SY, Blum SM, Cheng D, Pienta KJ, Reiter RE, Pitteri SJ, Huang J, Witte ON.
Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(42):E6457-E6466.
- PMID:
- 27694579
- PMCID:
- PMC5081658
Phosphoproteome Integration Reveals Patient-Specific Networks in Prostate Cancer.
Drake JM, Paull EO, Graham NA, Lee JK, Smith BA, Titz B, Stoyanova T, Faltermeier CM, Uzunangelov V, Carlin DE, Fleming DT, Wong CK, Newton Y, Sudha S, Vashisht AA, Huang J, Wohlschlegel JA, Graeber TG, Witte ON, Stuart JM.
Cell. 2016; 166(4):1041-1054. NIHMSID: NIHMS802379
- PMID:
- 27499020
- PMCID:
- PMC4985183
Park JW, Lee JK, Phillips JW, Huang P, Cheng D, Huang J, Witte ON.
Proceedings of the National Academy of Sciences of the United States of America. 2016; 113(16):4482-7.
- PMID:
- 27044116
- PMCID:
- PMC4843433
N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.
Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, McCaffrey EF, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Shokat KM, Gustafson WC, Huang J, Witte ON.
Cancer cell. 2016; 29(4):536-547. NIHMSID: NIHMS766191
- PMID:
- 27050099
- PMCID:
- PMC4829466
Clinical targeting of mutated and wild-type protein tyrosine kinases in cancer.
Drake JM, Lee JK, Witte ON.
Molecular and cellular biology. 2014; 34(10):1722-32.
- PMID:
- 24567371
- PMCID:
- PMC4019040
Drake JM, Graham NA, Lee JK, Stoyanova T, Faltermeier CM, Sud S, Titz B, Huang J, Pienta KJ, Graeber TG, Witte ON.
Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(49):E4762-9.
- PMID:
- 24248375
- PMCID:
- PMC3856845
Blastic plasmacytoid dendritic cell neoplasm.
Lee JK, Schiller G.
Clinical advances in hematology & oncology : H&O. 2012; 10(1):60-2.
- PMID:
- 22398811
Research Summary
We employ cutting-edge technologies including mouse and human prostate epithelial transformation systems; functional genomics; multi-omic data integration; high-throughput screening; small molecule drug discovery; and immuno-oncology to develop new approaches to stratify and treat prostate cancer. Current research projects include the functional characterization of drivers of aggressive prostate cancer, immunotherapeutic targeting of prostate cancer differentiation-specific antigens, and disruption of the protein stability of Myc and androgen receptor in advanced prostate cancer.