faculty

Tim Cherry

tjcherry@uw.edu
Assistant Professor

University of Washington

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Epigenomic Analysis of CNS Development and Disease

Faculty Contact Information

Building: Jack MacDonald Bldg. Seattle Children's Research Institute Room: 529 Box: M/S JMB-5 Phone: 206-884-1478 http://depts.washington.edu/cdbrm/wordpress/research-labs/cherry-lab/

Research Summary

The Cherry Lab investigates how the CNS, especially the visual system, develops and how genetic variations contribute to CNS disorders. Our ultimate goal is to develop better diagnostics and new therapeutic strategies to treat these disorders. We use single-cell-sequencing, CRISPR, and human organoid technologies to identify and characterize genetic variation affecting CNS enhancers and essential gene regulation. This powerful approach has already revealed novel disease-associated genetic variants in patients with inherited visual disorders.

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Publications

The following publications were retrieved from PubMed:

Mapping the cis-regulatory architecture of the human retina reveals noncoding genetic variation in disease.

Cherry TJ, Yang MG, Harmin DA, Tao P, Timms AE, Bauwens M, Allikmets R, Jones EM, Chen R, De Baere E, Greenberg ME.

Proc Natl Acad Sci U S A. 2020 Apr 21; 16(117)9001-9012

International multicentre review of perioperative management and outcome for catecholamine-producing tumours.

Groeben H, Walz MK, Nottebaum BJ, Alesina PF, Greenwald A, Schumann R, Hollmann MW, Schwarte L, Behrends M, Rössel T, Groeben C, Schäfer M, Lowery A, Hirata N, Yamakage M, Miller JA, Cherry TJ, Nelson A, Solorzano CC, Gigliotti B, Wang TS, Wietasch JKG, Friederich P, Sheppard B, Graham PH, Weingarten TN, Sprung J.

Br J Surg. 2020 Jan; 2(107)e170-e178

Chromatin Environment and Cellular Context Specify Compensatory Activity of Paralogous MEF2 Transcription Factors.

Majidi SP, Reddy NC, Moore MJ, Chen H, Yamada T, Andzelm MM, Cherry TJ, Hu LS, Greenberg ME, Bonni A.

Cell Rep. 2019 Nov 12; 7(29)2001-2015.e5

Correction: Mapping the genomic landscape of inherited retinal disease genes prioritizes genes prone to coding and noncoding copy-number variations.

Van Schil K, Naessens S, Van de Sompele S, Carron M, Aslanidis A, Van Cauwenbergh C, Mayer AK, Van Heetvelde M, Bauwens M, Verdin H, Coppieters F, Greenberg ME, Yang MG, Karlstetter M, Langmann T, De Preter K, Kohl S, Cherry TJ, Leroy BP, CNV Study Group., De Baere E.

Genet Med. 2019 Aug; 8(21)1998

Contribution of noncoding pathogenic variants to RPGRIP1-mediated inherited retinal degeneration.

Jamshidi F, Place EM, Mehrotra S, Navarro-Gomez D, Maher M, Branham KE, Valkanas E, Cherry TJ, Lek M, MacArthur D, Pierce EA, Bujakowska KM.

Genet Med. 2019 Mar; 3(21)694-704

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Lab Information

Location: 1900 9th Ave.
Building: Jack R. MacDonald Bldg.
Room: JMB 5
Box: M/S JMB-5
Phone: 206-884-1478
http://depts.washington.edu/cdbrm/wordpress/research-labs/cherry-lab/