faculty

Leslie Goo

lgoo@fredhutch.org
Assistant Member

Fred Hutch

Microbiology, Infection & Immunity

Humoral immunity to flaviviruses

Faculty Contact Information

Building: D4-213 Box: E5-110 Phone: 206-667-4127

Research Summary

We study the immune response to flaviviruses, which are transmitted to humans by mosquitoes and ticks and are significant threats to public health around the globe. They include dengue virus, West Nile virus, Zika virus, Japanese encephalitis virus and yellow fever virus. To understand the mechanisms behind immunity and disease development, we explore how antibodies interact with viral and cellular factors. Our research addresses both fundamental and translational questions, including those relevant to the development of vaccines and antiviral drugs.

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_5f92b76e728ed2514b1b2452&retmode=json
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Publications

The following publications were retrieved from PubMed:

Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics.

Durham ND, Agrawal A, Waltari E, Croote D, Zanini F, Fouch M, Davidson E, Smith O, Carabajal E, Pak JE, Doranz BJ, Robinson M, Sanz AM, Albornoz LL, Rosso F, Einav S, Quake SR, McCutcheon KM, Goo L.

Elife. 2019 Dec 10; (8)

Virus-inclusive single-cell RNA sequencing reveals the molecular signature of progression to severe dengue.

Zanini F, Robinson ML, Croote D, Sahoo MK, Sanz AM, Ortiz-Lasso E, Albornoz LL, Rosso F, Montoya JG, Goo L, Pinsky BA, Quake SR, Einav S.

Proc Natl Acad Sci U S A. 2018 Dec 26; 52(115)E12363-E12369

A protective human monoclonal antibody targeting the West Nile virus E protein preferentially recognizes mature virions.

Goo L, Debbink K, Kose N, Sapparapu G, Doyle MP, Wessel AW, Richner JM, Burgomaster KE, Larman BC, Dowd KA, Diamond MS, Crowe JE Jr, Pierson TC.

Nat Microbiol. 2019 Jan; 1(4)71-77

The Zika virus envelope protein glycan loop regulates virion antigenicity.

Goo L, DeMaso CR, Pelc RS, Ledgerwood JE, Graham BS, Kuhn RJ, Pierson TC.

Virology. 2018 Feb; (515)191-202

Accepting Students For:

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Lab Information

Location: Fred Hutchinson Cancer Research Center
Room: D4-213
Phone: 206-667-6418
https://www.fredhutch.org/en/faculty-lab-directory/goo-leslie.html