faculty

Rick McLaughlin

rmclaughlin@pnri.org
Assistant Professor

Pacific Northwest Research Institute

Computational Biology

Microbiology, Infection & Immunity

The impacts of transposable element evolution on human genomes and human disease

Faculty Contact Information

Box: 720 Broadway, Seattle, WA 98122 Phone: 206-568-1456

Research Summary

The McLaughlin lab seeks to understand how the evolutionary past of humans and their pathogens has shaped their current function. Fascinated by the scale of the impact transposable elements (TEs) have had on the human genome (around half of the human genome comes from these elements), our lab wants to understand the genetic mechanisms used by humans to defend against TEs, the genetic mechanisms used by TEs to support their own propagation, how host genomes have co-opted TEs to innovate immune defense against pathogens, and previously undescribed ways that TEs drive human disease.

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Publications

The following publications were retrieved from PubMed:

Combinatorial mutagenesis of rapidly evolving residues yields super-restrictor antiviral proteins.

Colón-Thillet R, Hsieh E, Graf L, McLaughlin RN Jr, Young JM, Kochs G, Emerman M, Malik HS.

PLoS Biol. 2019 Oct; 10(17)e3000181

Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner.

Sharma A, McLaughlin RN Jr, Basom RS, Kikawa C, OhAinle M, Yount JS, Emerman M, Overbaugh J.

PLoS Pathog. 2019 Jul; 7(15)e1007925

Genetic conflicts: the usual suspects and beyond.

McLaughlin RN Jr, Malik HS.

J Exp Biol. 2017 Jan 1; Pt 1(220)6-17

Conservation and Innovation of APOBEC3A Restriction Functions during Primate Evolution.

McLaughlin RN Jr, Gable JT, Wittkopp CJ, Emerman M, Malik HS.

Mol Biol Evol. 2016 Aug; 8(33)1889-901

Accepting Students For:

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Permanent

Lab Information

Location: Pacific Northwest Research Institute (PNRI)
Building: First Hill/Capitol Hill Campus
Room: 413
Phone: 206-568-1457
https://www.pnri.org/research/labs/mclaughlin-lab/