faculty

Shivani Srivastava

ssrivas2@fredhutch.org
Assistant Professor

Fred Hutch

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity

Immunotherapy using engineered T cells

Faculty Contact Information

Building: Lake Union Steam Plant Room: S3-213 Box: S3-204 Phone: 206-667-5103 https://www.fredhutch.org/en/faculty-lab-directory/srivastava-shivani.html

Research Summary

My lab is focused on applying principles of basic T cell biology towards the design for more effective adoptive T cell therapies for human cancers, with a particular emphasis on uncovering the factors within the tumor microenvironment that may limit the activity of tumor-specific T cells. We use clinically relevant mouse models to understand the mechanisms limiting the activity of engineered T cells in human cancers and develop strategies to overcome them that can be readily translated to the clinic.

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_60ff7992e1b53021523bac8e&retmode=json
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Publications

The following publications were retrieved from PubMed:

Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.

Srivastava S, Furlan SN, Jaeger-Ruckstuhl CA, Sarvothama M, Berger C, Smythe KS, Garrison SM, Specht JM, Lee SM, Amezquita RA, Voillet V, Muhunthan V, Yechan-Gunja S, Pillai SPS, Rader C, Houghton AM, Pierce RH, Gottardo R, Maloney DG, Riddell SR.

Cancer Cell. 2021 Feb 8; 2(39)193-208.e10

Correction: CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets.

Smigiel KS, Richards E, Srivastava S, Thomas KR, Dudda JC, Klonowski KD, Campbell DJ.

J Exp Med. 2019 Aug 5; 8(216)1965

Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting.

Srivastava S, Salter AI, Liggitt D, Yechan-Gunja S, Sarvothama M, Cooper K, Smythe KS, Dudakov JA, Pierce RH, Rader C, Riddell SR.

Cancer Cell. 2019 Mar 18; 3(35)489-503.e8

Chimeric Antigen Receptor T Cell Therapy: Challenges to Bench-to-Bedside Efficacy.

Srivastava S, Riddell SR.

J Immunol. 2018 Jan 15; 2(200)459-468

Targeted antibody-mediated depletion of murine CD19 CAR T cells permanently reverses B cell aplasia.

Paszkiewicz PJ, Fräßle SP, Srivastava S, Sommermeyer D, Hudecek M, Drexler I, Sadelain M, Liu L, Jensen MC, Riddell SR, Busch DH.

J Clin Invest. 2016 Nov 1; 11(126)4262-4272

Accepting Students For:

Rotation, Autumn
Rotation, Spring
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Rotation, Winter
Permanent

Lab Information

Location: Fred Hutchinson Cancer Research Center
Building: Lake Union Steam Plant
Room: S3-231
Box: S3-204
https://research.fredhutch.org/srivastava/en.html