Dana Miller
dlm16@uw.eduUniversity of Washington,
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Molecular genetics of responses to hypoxia and hydrogen sulfide
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
Caenorhabditis elegans HIF-1 Is Broadly Required for Survival in Hydrogen Sulfide.
Topalidou I, Miller DL.
G3 (Bethesda, Md.). 2017; 7(11):3699-3704.
- PMID:
- 28889102
- PMCID:
- PMC5677155
Computational Analysis of Lifespan Experiment Reproducibility.
Petrascheck M, Miller DL.
Frontiers in genetics. 2017; 8:92.
- PMID:
- 28713422
- PMCID:
- PMC5492194
Horsman JW, Miller DL.
The Journal of biological chemistry. 2016; 291(10):5320-5.
- PMID:
- 26677221
- PMCID:
- PMC4777863
Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span.
Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M.
Science (New York, N.Y.). 2015; 350(6266):1375-1378. NIHMSID: NIHMS766715
- PMID:
- 26586189
- PMCID:
- PMC4801033
Tissue-specific autophagy responses to aging and stress in C. elegans.
Chapin HC, Okada M, Merz AJ, Miller DL.
Aging. 2015; 7(6):419-34.
- PMID:
- 26142908
- PMCID:
- PMC4505168
Hypoxia disrupts proteostasis in Caenorhabditis elegans.
Fawcett EM, Hoyt JM, Johnson JK, Miller DL.
Aging cell. 2015; 14(1):92-101.
- PMID:
- 25510338
- PMCID:
- PMC4326909
Creating defined gaseous environments to study the effects of hypoxia on C. elegans.
Fawcett EM, Horsman JW, Miller DL.
Journal of visualized experiments : JoVE. 2012; (65):e4088.
- PMID:
- 22850348
- PMCID:
- PMC3570071
Miller DL, Budde MW, Roth MB.
PloS one. 2011; 6(9):e25476.
- PMID:
- 21980473
- PMCID:
- PMC3183046
C. elegans are protected from lethal hypoxia by an embryonic diapause.
Miller DL, Roth MB.
Current biology : CB. 2009; 19(14):1233-7. NIHMSID: NIHMS123762
- PMID:
- 19576771
- PMCID:
- PMC5024569
Hydrogen sulfide increases thermotolerance and lifespan in Caenorhabditis elegans.
Miller DL, Roth MB.
Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(51):20618-22.
- PMID:
- 18077331
- PMCID:
- PMC2154480
Research Summary
We study how animals maintain physiological homeostasis in stressful environments. Our research is currently focused on understanding the role of hydrogen sulfide signaling in cellular homeostasis. We have also discovered a new epigenetic “memory” of hydrogen sulfide, which is the focus of one projecxt. We are also interested in defining molecular and genetic pathways that mediate adaptive responses to low oxygen (hypoxia), and how they are modulated by sulfide. We are particularly interested in how the response to hypoxia impacts cellular proteostasis.