faculty

Behnam Nabet

bnabet@fredhutch.org

Assistant Professor

Fred Hutch

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Gene Expression, Cell Cycle & Chromosome Biology

Targeting oncogenic signaling by controlling protein homeostasis

Faculty Contact Information

Building: Hutchinson Room: C1-019 Box: C1-015 Phone: 206-667-4052 https://www.fredhutch.org/en/faculty-lab-directory/nabet-behnam.html

Research Summary

The Nabet lab is dedicated to targeting oncogenic signaling networks through control of protein homeostasis to advance new therapeutic strategies in cancer. We use multidisciplinary approaches including development of degradation-based technologies to discover, validate, and gain insights into clinically relevant targets. Through these efforts we work to deepen our biological understanding of the molecular circuits that drive cancer cell survival and growth as well as translate these insights into new therapeutic solutions for unmet medical needs.

DEI Statement

As the son of Iranian immigrants, I was in a fortunate position to access top research centers and to train with outstanding mentors. I recognize that not all individuals have early exposure and access to scientific research. I am dedicated to providing an equal opportunity for scholarship, learning, and growth to my trainees and to creating an inclusive and supportive lab environment. I also believe that scientific discovery must be open and collaborative and am committed to sharing technologies with the global community to promote therapeutic innovation.

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Publications

The following publications were retrieved from PubMed:

Synthesis and Structure-Activity relationships of cyclin-dependent kinase 11 inhibitors based on a diaminothiazole scaffold.

Li Z, Ishida R, Liu Y, Wang J, Li Y, Gao Y, Jiang J, Che J, Sheltzer JM, Robers MB, Zhang T, Westover KD, Nabet B, Gray NS.

Eur J Med Chem. 2022 Aug 5; (238)114433

Unleashing cell-intrinsic inflammation as a strategy to kill AML blasts.

Ellegast JM, Alexe G, Hamze A, Lin S, Uckelmann HJ, Rauch PJ, Pimkin M, Ross LS, Dharia NV, Robichaud AL, Saur Conway A, Khalid D, Perry JA, Wunderlich M, Benajiba L, Pikman Y, Nabet B, Gray NS, Orkin SH, Stegmaier K.

Cancer Discov. 2022 Apr 11;

A distinct core regulatory module enforces oncogene expression in KMT2A-rearranged leukemia.

Harada T, Heshmati Y, Kalfon J, Perez MW, Xavier Ferrucio J, Ewers J, Hubbell Engler B, Kossenkov A, Ellegast JM, Yi JS, Bowker A, Zhu Q, Eagle K, Liu T, Kai Y, Dempster JM, Kugener G, Wickramasinghe J, Herbert ZT, Li CH, Vrabič Koren J, Weinstock DM, Paralkar VR, Nabet B, Lin CY, Dharia NV, Stegmaier K, Orkin SH, Pimkin M.

Genes Dev. 2022 Mar 1; 5-6(36)368-389

MLL::AF9 degradation induces rapid changes in transcriptional elongation and subsequent loss of an active chromatin landscape.

Olsen SN, Godfrey L, Healy JP, Choi YA, Kai Y, Hatton C, Perner F, Haarer EL, Nabet B, Yuan GC, Armstrong SA.

Mol Cell. 2022 Mar 17; 6(82)1140-1155.e11

TRIM8 modulates the EWS/FLI oncoprotein to promote survival in Ewing sarcoma.

Seong BKA, Dharia NV, Lin S, Donovan KA, Chong S, Robichaud A, Conway A, Hamze A, Ross L, Alexe G, Adane B, Nabet B, Ferguson FM, Stolte B, Wang EJ, Sun J, Darzacq X, Piccioni F, Gray NS, Fischer ES, Stegmaier K.

Cancer Cell. 2021 Sep 13; 9(39)1262-1278.e7

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Location: Fred Hutch
Building: Hutchinson
Room: C1-187
https://research.fredhutch.org/nabet/en.html