faculty

Rong Tian

rongtian@uw.edu
Professor

University of Washington

Biochemistry

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Mitochondrial and Metabolic mechanisms of human diseases

Faculty Contact Information

Building: SLU North Building Room: N130 Box: Box 358057 Phone: 206-543-8982 Alt Phone: 206-616-5672 https://sites.uw.edu/mmcslu/faculty/rong_tian-md-phd/

Research Summary

The Tian Laboratory focuses on the roles of cell metabolism and mitochondrial function in the pathogenesis of human diseases. Our research combines the high resolution NMR techniques and metabolomics with the ability to target molecular regulatory mechanisms via genetic manipulation in animal models. Current research topics include:
Mitochondrial mechanisms in stress response;
Metabolic reprogramming during the development and disease;
Mitochondrial protein interactome
Targeting NAD metabolism for therapy

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Publications

The following publications were retrieved from PubMed:

A novel approach to measure mitochondrial respiration in frozen biological samples.

Acin-Perez R, Benador IY, Petcherski A, Veliova M, Benavides GA, Lagarrigue S, Caudal A, Vergnes L, Murphy AN, Karamanlidis G, Tian R, Reue K, Wanagat J, Sacks H, Amati F, Darley-Usmar VM, Liesa M, Divakaruni AS, Stiles L, Shirihai OS.

EMBO J. 2020 May 20; e104073

Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Tian R, Colucci WS, Arany Z, Bachschmid MM, Ballinger SW, Boudina S, Bruce JE, Busija DW, Dikalov S, Dorn GW II, Galis ZS, Gottlieb RA, Kelly DP, Kitsis RN, Kohr MJ, Levy D, Lewandowski ED, McClung JM, Mochly-Rosen D, O'Brien KD, O'Rourke B, Park JY, Ping P, Sack MN, Sheu SS, Shi Y, Shiva S, Wallace DC, Weiss RG, Vernon HJ, Wong R, Schwartz Longacre L.

Circulation. 2019 Oct 1; 14(140)1205-1216

Cellular Interactome Dynamics during Paclitaxel Treatment.

Chavez JD, Keller A, Zhou B, Tian R, Bruce JE.

Cell Rep. 2019 Nov 19; 8(29)2371-2383.e5

TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.

Jung HS, Shimizu-Albergine M, Shen X, Kramer F, Shao D, Vivekanandan-Giri A, Pennathur S, Tian R, Kanter JE, Bornfeldt KE.

J Lipid Res. 2020 Jan; 1(61)33-44

Metabolic Remodeling Promotes Cardiac Hypertrophy by Directing Glucose to Aspartate Biosynthesis.

Ritterhoff J, Young S, Villet O, Shao D, Neto FC, Bettcher LF, Hsu YA, Kolwicz SC Jr, Raftery D, Tian R.

Circ Res. 2020 Jan 17; 2(126)182-196

Accepting Students For:

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Permanent

Lab Information

Location: UW SLU campus
Building: North Building
Room: N130
Box: Box 358057
Phone: 206-543-8982
https://sites.uw.edu/mmcslu/laboratories/research-laboratories-tian-lab-2-2-2/