faculty

Rong Tian

rongtian@uw.edu

Professor

University of Washington

Biochemistry

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Mitochondrial and Metabolic mechanisms of human diseases

Faculty Contact Information

Building: SLU North Building Room: N130 Box: Box 358057 Phone: 206-543-8982 Alt Phone: 206-616-5672 https://sites.uw.edu/mmcslu/faculty/rong_tian-md-phd/

Research Summary

The Tian Laboratory focuses on the roles of cell metabolism and mitochondrial function in the pathogenesis of human diseases. Our research combines the high resolution NMR techniques and metabolomics with the ability to target molecular regulatory mechanisms via genetic manipulation in animal models. Current research topics include:
Mitochondrial mechanisms in stress response;
Metabolic reprogramming during the development and disease;
immunometabolism and sterile inflammation
Stem cell metabolism

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Publications

The following publications were retrieved from PubMed:

Upregulation of mitochondrial ATPase inhibitory factor 1 (ATPIF1) mediates increased glycolysis in mouse hearts.

Zhou B, Caudal A, Tang X, Chavez JD, McMillen TS, Keller A, Villet O, Zhao M, Liu Y, Ritterhoff J, Wang P, Kolwicz SC Jr, Wang W, Bruce JE, Tian R.

J Clin Invest. 2022 May 16; 10(132)

Diabetes Suppresses Glucose Uptake and Glycolysis in Macrophages.

Matsuura Y, Shimizu-Albergine M, Barnhart S, Kramer F, Hsu CC, Kothari V, Tang J, Gharib SA, Kanter JE, Abel ED, Tian R, Shao B, Bornfeldt KE.

Circ Res. 2022 Mar 4; 5(130)779-781

Elevated MCU Expression by CaMKIIδB Limits Pathological Cardiac Remodeling.

Wang P, Xu S, Xu J, Xin Y, Lu Y, Zhang H, Zhou B, Xu H, Sheu SS, Tian R, Wang W.

Circulation. 2022 Apr 5; 14(145)1067-1083

Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes.

Wu J, Singh K, Lin A, Meadows AM, Wu K, Shing V, Bley M, Hassanzadeh S, Huffstutler RD, Schmidt MS, Blanco LP, Tian R, Brenner C, Pirooznia M, Kaplan MJ, Sack MN.

J Clin Invest. 2022 Mar 1; 5(132)

Amino acid primed mTOR activity is essential for heart regeneration.

Miklas JW, Levy S, Hofsteen P, Mex DI, Clark E, Muster J, Robitaille AM, Sivaram G, Abell L, Goodson JM, Pranoto I, Madan A, Chin MT, Tian R, Murry CE, Moon RT, Wang Y, Ruohola-Baker H.

iScience. 2022 Jan 21; 1(25)103574

Accepting Students For:

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Permanent

Lab Information

Location: UW SLU campus
Building: North Building
Room: N130
Box: Box 358057
Phone: 206-543-8982
https://sites.uw.edu/mmcslu/laboratories/research-laboratories-tian-lab/research/