faculty

Paul Phillips

pemp@uw.edu
Professor

University of Washington

Psychiatry & Behavioral Sciences

Basic Sciences

Neuroscience

Dopamine transmission in rodents during normal cognition and disease.

Faculty Contact Information

Building: HSB Room: J-117a Box: 356560 http://faculty.washington.edu/pemp

Research Summary

The key focus of our lab is to precisely define the role of dopamine neurotransmission in cognition and decision making. We use this information to address how molecular processes that control this transmitter impact motivated behavior, and to understand how this signaling is altered by mental pathology. We use fast-scan cyclic voltammetry at chronically implanted electrodes that can track dopamine transmission with sub-second resolution longitudinally over the course of months in behaving animals, or acutely in reduced preparations such as brain slices.

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Publications

The following publications were retrieved from PubMed:

The Protective Action Encoding of Serotonin Transients in the Human Brain.

Moran RJ, Kishida KT, Lohrenz T, Saez I, Laxton AW, Witcher MR, Tatter SB, Ellis TL, Phillips PE, Dayan P, Montague PR.

Neuropsychopharmacology. 2018 May; 6(43)1425-1435

Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase.

Schattauer SS, Land BB, Reichard KL, Abraham AD, Burgeno LM, Kuhar JR, Phillips PEM, Ong SE, Chavkin C.

Nat Commun. 2017 Sep 29; 1(8)743

Dopamine Encodes Retrospective Temporal Information in a Context-Independent Manner.

Fonzi KM, Lefner MJ, Phillips PEM, Wanat MJ.

Cell Rep. 2017 Aug 22; 8(20)1765-1774

Hitchhiker's Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry.

Rodeberg NT, Sandberg SG, Johnson JA, Phillips PE, Wightman RM.

ACS Chem Neurosci. 2017 Feb 15; 2(8)221-234

Pramipexole enhances disadvantageous decision-making: Lack of relation to changes in phasic dopamine release.

Pes R, Godar SC, Fox AT, Burgeno LM, Strathman HJ, Jarmolowicz DP, Devoto P, Levant B, Phillips PE, Fowler SC, Bortolato M.

Neuropharmacology. 2017 Mar 1; (114)77-87

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Lab Information

Building: HSB
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