faculty

Daniel Stetson

stetson@uw.edu
Associate Professor

University of Washington

Immunology

Cell Signaling & Cell/Environment Interactions

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

Innate immune detection of nucleic acids

Faculty Contact Information

Building: 750 Republican St Room: E-453 Box: 358059 Phone: 206-543-6633 http://immunology.washington.edu/daniel-b-stetson-phd

Research Summary

Research in the Stetson lab focuses on mechanisms by which cells detect and respond to viral infection. All organisms have viral pathogens, and an ancient and fundamental mechanism for detecting viral infection makes use of sensors that recognize viral nucleic acids. We study these sensors, how they are activated, how they are regulated, how they organize protective immunity to virus infection, how we can trigger them with better vaccines, and how we can treat human autoimmune diseases caused by inappropriate activation of these same pathways.

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Publications

The following publications were retrieved from PubMed:

Editorial overview: Autoimmunity: A new frontier awaits.

Stetson DB

Curr Opin Immunol. 2018 Dec; (55)iii-iv

SUMO2 and SUMO3 redundantly prevent a noncanonical type I interferon response.

Crowl JT, Stetson DB.

Proc Natl Acad Sci U S A. 2018 Jun 26; 26(115)6798-6803

Intracellular Nucleic Acid Sensing Triggers Necroptosis through Synergistic Type I IFN and TNF Signaling.

Brault M, Olsen TM, Martinez J, Stetson DB, Oberst A.

J Immunol. 2018 Apr 15; 8(200)2748-2756

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.

Nat Immunol. 2017 Jul; 7(18)744-752

Intracellular Nucleic Acid Detection in Autoimmunity.

Crowl JT, Gray EE, Pestal K, Volkman HE, Stetson DB.

Annu Rev Immunol. 2017 Apr 26; (35)313-336

Accepting Students For:

Rotation, Spring
Rotation, Winter
Permanent

Lab Information

Location: University of Washington Department of Immunology
Building: 750 Republican St
Room: E-440
Box: 358059
Phone: 206-221-5743