Ricky Padilla-Del Vallerickyyyy@uw.edu
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution
While mobile genetic elements inflate and sculpture the host genome, intrinsic genomic defenses arise in response to battle change and reestablish order. This co-evolutionary interplay allows pathogens like the retrotransposon Long Interspersed Element 1 (LINE-1) to generate biologically expensive changes that translate into mutagenic events, and consequently disease. As part of the McLaughlin Lab, I use evolutionary-guided methods driven by phylogenetics and experimental evolution to functionally access and describe the nature and dynamics of LINE-1 diversification and its consequences in individual human genomes.