student

Sarah Crist

scrist12@uw.edu

Fred Hutchinson Cancer Research Center, 

Public Health Science/ Translational Research Program

Cancer Biology

Entry Quarter: Autumn 2015

Lab Information

Advisor: Cyrus Ghajar

Publications

Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy.

Carlson P, Dasgupta A, Grzelak CA, Kim J, Barrett A, Coleman IM, Shor RE, Goddard ET, Dai J, Schweitzer EM, Lim AR, Crist SB, Cheresh DA, Nelson PS, Hansen KC, Ghajar CM.

Nat Cell Biol. 2019 Feb;21(2):238-250. doi: 10.1038/s41556-018-0267-0. Epub 2019 Jan 21.

PMID:
30664790

Friends with Benefits: Microenvironmental NRG1β and HGF Mediate HER2-Targeted Resistance in L-HER2+ and HER2E Breast Cancer.

Crist SB, Ghajar CM.

Cell Syst. 2018 Mar 28;6(3):268-270. doi: 10.1016/j.cels.2018.03.005.

SENP8 limits aberrant neddylation of NEDD8 pathway components to promote cullin-RING ubiquitin ligase function.

Coleman KE, Békés M, Chapman JR, Crist SB, Jones MJ, Ueberheide BM, Huang TT.

Elife. 2017 May 5;6. pii: e24325. doi: 10.7554/eLife.24325.

ATR-mediated phosphorylation of FANCI regulates dormant origin firing in response to replication stress.

Chen YH, Jones MJ, Yin Y, Crist SB, Colnaghi L, Sims RJ 3rd, Rothenberg E, Jallepalli PV, Huang TT.

Mol Cell. 2015 Apr 16;58(2):323-38. doi: 10.1016/j.molcel.2015.02.031. Epub 2015 Apr 2.

DUB-resistant ubiquitin to survey ubiquitination switches in mammalian cells.

Békés M, Okamoto K, Crist SB, Jones MJ, Chapman JR, Brasher BB, Melandri FD, Ueberheide BM, Denchi EL, Huang TT.

Cell Rep. 2013 Nov 14;5(3):826-38. doi: 10.1016/j.celrep.2013.10.008. Epub 2013 Nov 7.

Research Summary

My research explores the idea that skeletal muscles express unique metastasis suppressors that restrict DTC outgrowth.