student

Nicholas Maurice

nmaurice@fredhutch.org

Fred Hutch

Vaccine and Infections Disease

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity (Area Director)

Entry Quarter: Summer 2015
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_61042e6cd0756334e569edf6&retmode=json
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Lost Soldiers or Special Forces?" 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Publications

The following publications were retrieved from PubMed:

Inflammatory signals are sufficient to elicit TOX expression in mouse and human CD8+ T cells.

Maurice NJ, Berner J, Taber AK, Zehn D, Prlic M.

JCI Insight. 2021 Jul 8; 13(6)

The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells.

Maurice NJ, Taber AK, Prlic M.

J Immunol. 2021 Feb 1; 3(206)455-462

Human Tissue-Resident Memory T Cells in the Maternal-Fetal Interface. Lost Soldiers or Special Forces?

DeJong CS, Maurice NJ, McCartney SA, Prlic M.

Cells. 2020 Dec 16; 12(9)

Inflammatory Cytokines Induce Sustained CTLA-4 Cell Surface Expression on Human MAIT Cells.

Berkson JD, Slichter CK, DeBerg HA, Delaney MA, Woodward-Davis AS, Maurice NJ, Lwo Y, Ko A, Hsu J, Chiu YW, Linsley PS, Dixon D, Prlic M.

Immunohorizons. 2020 Jan 23; 1(4)14-22

CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells.

Maurice NJ, McElrath MJ, Andersen-Nissen E, Frahm N, Prlic M.

Nat Commun. 2019 Nov 1; 1(10)4987

Research Summary

By convention, memory T cells are selective listeners, reactivating upon reencounter with their cognate antigen. Despite this, T cells also eavesdrop on inflammatory cues, gaining innate-like killing functions during infections. Nevertheless, inflammation type is contingent on infection and tissue microenvironment. Here I seek to leverage the gamut inflammatory cues to tune T cell function and fate.

Lab Information

Advisor: Martin Prlic
Box: E5-110
http://research.fhcrc.org/prlic/en.html
206-667-6389