Fred Hutchinson Cancer Research Institute,
Public Health Sciences/Human Biology
Cancer Biology (Area Director)
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
I study how the lymph node microenvironment regulates disseminated tumor cell (DTC) dormancy. DTCs are thought to initiate metastasis, the spread of cancer throughout the body. In order to survive in their new environments, DTCs can enter dormancy, a state characterized by reversible cell cycle arrest, immune evasion, and chemoresistance. The microenvironment of metastatic tissues has been implicated in regulating dormancy and reawakening. My project focuses on characterizing components of the lymph node microenvironment (cells, soluble factors, ECM proteins, etc.) that may impact DTC behavior.