Amanda Bradley

University of Washington, 


Cancer Biology

Cell Signaling & Cell/Environment Interactions (Area Director)

Gene Expression, Cell Cycle & Chromosome Biology

Entry Quarter: Summer 2015

Lab Information

Advisor: Richard Gardner


Dynamic Sumoylation of a Conserved Transcription Corepressor Prevents Persistent Inclusion Formation during Hyperosmotic Stress.

Oeser ML, Amen T, Nadel CM, Bradley AI, Reed BJ, Jones RD, Gopalan J, Kaganovich D, Gardner RG.

PLoS Genet. 2016 Jan 22;12(1):e1005809. doi: 10.1371/journal.pgen.1005809. eCollection 2016 Jan.

Single-cell genetic analysis reveals insights into clonal development of prostate cancers and indicates loss of PTEN as a marker of poor prognosis.

Heselmeyer-Haddad KM, Berroa Garcia LY, Bradley A, Hernandez L, Hu Y, Habermann JK, Dumke C, Thorns C, Perner S, Pestova E, Burke C, Chowdhury SA, Schwartz R, Schäffer AA, Paris PL, Ried T.

Am J Pathol. 2014 Oct;184(10):2671-86. doi: 10.1016/j.ajpath.2014.06.030. Epub 2014 Aug 14.

Single-cell genetic analysis of ductal carcinoma in situ and invasive breast cancer reveals enormous tumor heterogeneity yet conserved genomic imbalances and gain of MYC during progression.

Heselmeyer-Haddad K, Berroa Garcia LY, Bradley A, Ortiz-Melendez C, Lee WJ, Christensen R, Prindiville SA, Calzone KA, Soballe PW, Hu Y, Chowdhury SA, Schwartz R, Schäffer AA, Ried T.

Am J Pathol. 2012 Nov;181(5):1807-22. doi: 10.1016/j.ajpath.2012.07.012. Epub 2012 Oct 8.

Research Summary

I am currently studying the role sumoylation plays in protein modification and transcriptional regulation during environmental stress in yeast.