John Scott


University of Washington, 

Cell Signaling & Cell/Environment Interactions

Signal transduction events that are controlled by anchoring proteins

Faculty Contact Information

Building: Health Sciences Building Room: K-336B Box: 357750 http://faculty.washington.edu/scottjdw/index.html

Lab Information

Location: University of Washington Building: Health Sciences Builcing Room: K-316 http://faculty.washington.edu/scottjdw/index.html

Accepting Students For:

Rotation, Spring
Rotation, Winter


The following publications were retrieved from PubMed:

Protein kinase A activation: Something new under the sun?

Smith FD, Scott JD.

J Cell Biol. 2018 Jun 4; 6(217)1895-1897

Using an Innovative Telehealth Model to Support Community Providers Who Deliver Perinatal HIV Care.

Ness TE, Annese MF, Martinez-Paz N, Unruh KT, Scott JD, Wood BR.

AIDS Educ Prev. 2017 Dec; 6(29)516-526

HIV Pre-exposure Prophylaxis Prescribing Through Telehealth.

Stekler JD, McMahan V, Ballinger L, Viquez L, Swanson F, Stockton J, Crutsinger-Perry B, Kern D, Scott JD.

J Acquir Immune Defic Syndr. 2018 Apr 15; 5(77)e40-e42

Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity.

Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD.

Elife. 2017 Oct 2; (6)

Research Summary

His research program focuses on defining the intracellular communication networks that promote specificity in signal transduction events. Dr. Scott’s lab has identified a family of A-kinase–anchoring proteins (AKAPs) that target the cAMP-dependent protein kinase (PKA) and other signaling enzymes to specific subcellular sites. AKAPs influence the regulation of physiological processes by bringing enzymes close to their appropriate effectors and substrates at precisely the right moment. Dr. Scott and his lab have made significant progress on establishing the AKAP model, the functional consequence