Changes

When an experimental picture is worth a thousand genes

Gene Expression, Cell Cycle & Chromosome Biology

The duplication, organization, maintenance and interpretation of the DNA code is one of the most fundamental processes in life. Seattle MCB faculty take various approaches to investigate how cells maintain proper cell cycle progression, chromosomes organization, DNA replication, transcription, DNA repair and chromosome segregation.

Model Curricula

Autumn

CONJ 537
Mechanisms of Transcriptional Regulation

winter

CONJ 544
Protein Structure, Modification and Regulation

spring

MCB 539
Biological Basis of Neoplasia

PHCOL 535
Transcriptional Control in Human Disease

Dr. Sue Biggins, an HHMI investigator, studies how chromosomes segregate properly

Chromosomal Collaboration

The MCB Program has a strong focus on understanding various aspects of chromosome biology. We feature research from the structure and function of chromatin to the dynamics of chromosome movement during cell division. The faculty are interactive and collaborative, as demonstrated by a number of groups that meet regularly to investigate topics relevant to chromosomes.

Check out our Mitosis Club

Faculty Area Directors: Linda Wordeman, Toshio Tsukiyama

Student Area Directors: Amy Lanctot, Amy Spens

Area Of interest Faculty

Featured Research

Area Directors

Faculty Area Directors: Linda Wordeman, Toshi Tsukiyama

Student Area Directors: Molly Zych, Ellen Paatela, Chase Suiter

Lab Openings

Bedalov Lab:
All Quarters, Permanent Position

Stergachis Lab:
All Quarters, Permanent Position

Epigenetics, Human Disease, Gene Regulation, Clinical Genomics

Dudley Lab:
All Quarters, Permanent Position

Yeast, Genetics, Genomics, Technology Development, Biofilm formation, Antifungal drugs

Wills Lab:
Spring, Winter, Permanent Position

Hsieh Lab:
All Quarters, Permanent Position

Translation control, Ribosome profiling, Cancer Biology, RNA biology

Aitchison Lab:
All Quarters, Permanent Position

systems cell biology, host-pathogen interactions, infectious diseases

Rajan Lab:
All Quarters, Permanent Position

Fat's impact on cognition & immunity

Geballe Lab:
Autumn, Spring, Winter

virus

Brewer Lab:
Autumn, Spring, Winter, Permanent Position

Beliveau Lab:
All Quarters, Permanent Position

Chromosomes, imaging technologies

Cabernard Lab:
All Quarters, Permanent Position

Asymmetric cell division, stem cells, Drosophila, cell division, cytokinesis

Carvalho Lab:
All Quarters, Permanent Position

Structural Variation, Genomic Disorders, Mendelian Diseases

Disteche Lab:
All Quarters, Permanent Position

epigenetic regulation,chromatin structure,gene regulation,dosage compensation,X chromosome,nuclear structure

Avgousti Lab:
Spring, Summer, Winter, Permanent Position

Chromatin, adenovirus, herpesvirus, histones

MacPherson Lab:
All Quarters, Permanent Position

mouse models, cancer genetics, targeted therapy

Grady Lab:
Spring, Winter

Smith Lab:
All Quarters

DNA break repair, genetic recombination

Hatch Lab:
All Quarters, Permanent Position

nuclear envelope, nuclear lamins, micronuclei, genome instability, aneuploidy

Kiem, MD, PhD Lab:
All Quarters, Permanent Position

The Kiem Lab studies cell and gene therapy with a particular interest in the biology of blood and marrow stem cells and the development and use of novel genome editing technologies. The overall goal is to develop better stem cell transplant and cell and g

Malik Lab:
Autumn, Spring, Winter, Permanent Position

centromeres, heterochromatin, Drosophila, viruses, budding yeast, fission yeast, mitochondria, speciation, retroelements, histone variants, Tetrahymena, bacteria, phage, protein, evolution, cytoskeleton, multigene families, histones

Lee Lab:
All Quarters, Permanent Position

prostate cancer, epithelial transformation, antigen discovery, cellular immunotherapy, small molecule drug discovery

Ray Lab:
Autumn, Spring, Summer, Permanent Position

autoimmunity, genetic variation, T cells, enhancer biology

Chamberlain Lab:
Spring, Winter, Permanent Position

Gene therapy, muscular dystrophy, CRISPR/Cas9, AAV vectors, lentiviral vectors, dystrophin, FKRP, DMD, LGMD, genome editing

Bomsztyk Lab:
All Quarters, Permanent Position

epigenetics,transcription,disease, high throughput technologies

Kawasumi Lab:
All Quarters, Permanent Position

Skin cancer epigenetics

Kueh Lab:
Spring, Summer, Winter, Permanent Position

Immunology, stem cell biology, quantitative biology, systems biology, synthetic biology, live-cell imaging,

Kugel Lab:
All Quarters, Permanent Position

Dunham Lab:
Autumn, Spring, Winter, Permanent Position

yeast, genomics, genetics, copy number variation, QTL, experimental evolution

McKnight Lab:
All Quarters, Permanent Position

PKA, cAMP, obesity, hypothalamus, leptin, gene expression, memory, learning

Oshima Lab:

Aging, Genetics, Progeria, Werner syndrome

Nelson Lab:
All Quarters, Permanent Position

hormonal carcinogenesis, tumor microenvironment, androgen receptor, prostate cancer, mutation, biomarkers, metastasis

Liu Lab:
All Quarters, Permanent Position

Signaling, Cardiac Remodeling, Heart Failure, Cardiomyocyte, Cell Death, Apoptosis, Necroptosis, Animal Models

Queitsch Lab:
All Quarters, Permanent Position

gene regulation, chaperones, rDNA, microsatellites, STRs, protein folding, sequencing technologies, complex traits, epistasis, Hsp90, heat stress, natural variation, mutation penetrance

Subramaniam Lab:
Autumn, Spring, Winter, Permanent Position

computational biology, gene regulation, mrna translation

Yablonka-Reuveni Lab:

Bumgarner Lab:
All Quarters

Bioformatics, host-virus interactions, genomics, expression analysis, microarrays

Savan Lab:
All Quarters, Permanent Position

RNA regulation, gene expression, antiviral response

Biggins Lab:
All Quarters, Permanent Position

chromosomes, spindle checkpoint, centromere, microtubules, kinetochore, histone variants, tension, aneuploidy

Lee Lab:
All Quarters, Permanent Position

Hematopoietic stem cells, leukemia, splicing

Hahn Lab:
All Quarters, Permanent Position

transcription, gene regulation, genomics, structure, coactivator, RNA polymerase, biochemistry

Shechner Lab:
All Quarters, Permanent Position

Nuclear architecture, Noncoding RNAs, ncRNA, chromatin, nucleolus, RNA structure and function, RNA localization, technology development

Tapscott Lab:
All Quarters, Permanent Position

DUX4, MyoD, NeuroD, cancer, immune evasion, germline cells, early embryo, muscular dystrophy

Imaizumi Lab:
All Quarters

Circadian clock, flowering, developmental transition

Davis Lab:
Autumn, Spring, Winter, Permanent Position

mitosis, cell cycle, biochemistry, biophysics, genetics, centrosome, kinetochore, microtubule, cancer

Cherry Lab:
All Quarters, Permanent Position

single-cell, epigenomics, CNS, visual system, human disease, organoids

Reh Lab:
Autumn, Spring, Winter, Permanent Position

retina, regeneration, stem cells, reprogramming, ESC, brain, transcription, epigenetics, chromatin

Tsukiyama Lab:
All Quarters, Permanent Position

chromatin, transcription, DNA replication, nucleosomes, deep sequencing, bioinformatics, lncRNA, checkpoint, quiescence, chromatin remodeling, histone deacetylation