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When an experimental picture is worth a thousand genes

Gene Expression, Cell Cycle & Chromosome Biology

The duplication, organization, maintenance and interpretation of the DNA code is one of the most fundamental processes in life. Seattle MCB faculty take various approaches to investigate how cells maintain proper cell cycle progression, chromosomes organization, DNA replication, transcription, DNA repair and chromosome segregation.

Suggested Courses

Autumn

CONJ 537
Mechanisms of Transcriptional Regulation

winter

CONJ 544
Protein Structure, Modification and Regulation

spring

MCB 539
Biological Basis of Neoplasia

PHCOL 535
Transcriptional Control in Human Disease

Dr. Sue Biggins, an HHMI investigator, studies how chromosomes segregate properly

Chromosomal Collaboration

The MCB Program has a strong focus on understanding various aspects of chromosome biology. We feature research from the structure and function of chromatin to the dynamics of chromosome movement during cell division. The faculty are interactive and collaborative, as demonstrated by a number of groups that meet regularly to investigate topics relevant to chromosomes.

Check out our Mitosis Club

Faculty Area Directors: Linda Wordeman, Toshio Tsukiyama

Student Area Directors: Amy Lanctot, Amy Spens

Area Of interest Faculty

Featured Research

Area Directors

Faculty Area Directors: Linda Wordeman, Toshi Tsukiyama

Student Area Directors: Molly Zych, Ellen Paatela, Chase Suiter

Lab Openings

Bedalov Lab:
All Quarters, Permanent Position

Stergachis Lab:
All Quarters, Permanent Position

Epigenetics, Human Disease, Gene Regulation, Clinical Genomics

Dudley Lab:
All Quarters, Permanent Position

Yeast, Genetics, Genomics, Technology Development, Biofilm formation, Antifungal drugs

Wills Lab:
Spring, Winter, Permanent Position

Transcriptional regulation of vertebrate regeneration

Hsieh Lab:
All Quarters, Permanent Position

Translation control, Cancer Biology, RNA biology, Functional Genomics

Aitchison Lab:
All Quarters, Permanent Position

systems cell biology, host-pathogen interactions, infectious diseases

Rajan Lab:
All Quarters, Permanent Position

Fat's impact on cognition & immunity

Geballe Lab:
Spring, Winter

virus, translation

Brewer Lab:
Autumn, Spring, Winter, Permanent Position

Beliveau Lab:
All Quarters, Permanent Position

Chromosomes, imaging technologies

Swalla Lab:
All Quarters, Permanent Position

Evolution and Development, Genetics, Regeneration

Traxler Lab:
Autumn, Spring, Summer, Permanent Position

bacterial conjugation, antibiotic resistance, protein biogenesis,

Cabernard Lab:
All Quarters, Permanent Position

Asymmetric cell division, stem cells, Drosophila, cell division, cytokinesis

Carvalho Lab:
All Quarters, Permanent Position

Structural Variation, Mendelian Diseases, Complex Rearrangements, Inversions, Robinow Syndrome, Genomic Disorders

Disteche Lab:
All Quarters, Permanent Position

epigenetic regulation,chromatin structure,gene regulation,dosage compensation,X chromosome,nuclear structure

MacPherson Lab:
All Quarters, Permanent Position

mouse models, cancer genetics, targeted therapy

Eisenman Lab:
Spring, Summer, Winter

myc, transcription, oncogene, tumor suppressor, network

Chen Lab:
All Quarters

rhabdomyosarcoma, cancer, zebrafish, self-renewal, differentiation, muscle

Grady Lab:
Spring, Winter

Smith Lab:
All Quarters

DNA break repair, genetic recombination

Hatch Lab:
All Quarters, Permanent Position

nuclear envelope, nuclear lamins, micronuclei, genome instability, aneuploidy

Kiem, MD, PhD Lab:
All Quarters, Permanent Position

Kiem Lab, cell and gene therapy, blood and marrow stem cells, novel genome editing technologies, stem cell transplant, fanconi anemia

Malik Lab:
Autumn, Spring, Winter, Permanent Position

centromeres, heterochromatin, Drosophila, viruses, budding yeast, fission yeast, mitochondria, speciation, retroelements, histone variants, Tetrahymena, bacteria, phage, protein, evolution, cytoskeleton, multigene families, histones

Lee Lab:
All Quarters, Permanent Position

prostate cancer, epithelial transformation, antigen discovery, cellular immunotherapy, small molecule drug discovery

Ray Lab:
All Quarters, Permanent Position

autoimmunity, genetic variation, T cells, enhancer biology

Chamberlain Lab:
Spring, Winter, Permanent Position

Gene therapy, muscular dystrophy, CRISPR/Cas9, AAV vectors, lentiviral vectors, dystrophin, FKRP, DMD, LGMD, genome editing

Bomsztyk Lab:
All Quarters, Permanent Position

epigenetics,transcription,disease, high throughput technologies

Kawasumi Lab:
All Quarters, Permanent Position

Skin cancer epigenetics

Kueh Lab:
Spring, Summer, Winter, Permanent Position

Immunology, stem cell biology, quantitative biology, systems biology, synthetic biology, live-cell imaging,

Kugel Lab:
All Quarters, Permanent Position

Lehrbach Lab:
All Quarters, Permanent Position

proteasome, proteostasis, aging, C. elegans, genetics

McKnight Lab:
All Quarters, Permanent Position

PKA, cAMP, obesity, hypothalamus, leptin, gene expression, memory, learning

Monnat Lab:
All Quarters

Cancer biology, bioengineering, global health

Guo Lab:
All Quarters, Permanent Position

DNA supercoiling, replication, nucleoid structuring proteins, topoisomerase, Hi-C

Oshima Lab:

Aging, Genetics, Progeria, Werner syndrome

Liu Lab:
All Quarters, Permanent Position

Signaling, Cardiac Remodeling, Heart Failure, Cardiomyocyte, Cell Death, Apoptosis, Necroptosis, Animal Models

Queitsch Lab:
All Quarters, Permanent Position

gene regulation, chaperones, rDNA, microsatellites, STRs, protein folding, sequencing technologies, complex traits, epistasis, Hsp90, heat stress, natural variation, mutation penetrance

Yablonka-Reuveni Lab:

Bumgarner Lab:
All Quarters

Bioformatics, host-virus interactions, genomics, expression analysis, microarrays

Savan Lab:
All Quarters, Permanent Position

RNA regulation, gene expression, antiviral response

Biggins (she/her) Lab:
All Quarters, Permanent Position

chromosomes, spindle checkpoint, centromere, microtubules, kinetochore, histone variants, tension, aneuploidy

Lee Lab:
All Quarters, Permanent Position

Hematopoietic stem cells, leukemia, splicing

Hahn Lab:
Spring, Summer, Winter, Permanent Position

transcription, gene regulation, genomics, structure, coactivator, RNA polymerase, biochemistry

Shechner Lab:
All Quarters, Permanent Position

Cellular architecture, Nuclear architecture, Noncoding RNAs, ncRNA, chromatin, nucleolus, RNA structure and function, RNA localization, technology development

Tapscott Lab:
All Quarters, Permanent Position

DUX4, MyoD, NeuroD, cancer, immune evasion, germline cells, early embryo, muscular dystrophy

Imaizumi Lab:
All Quarters

Circadian clock, flowering, developmental transition

Davis Lab:
Autumn, Spring, Winter, Permanent Position

mitosis, cell cycle, biochemistry, biophysics, genetics, centrosome, kinetochore, microtubule, cancer

Cherry Lab:
All Quarters, Permanent Position

single-cell, epigenomics, CNS, visual system, human disease, organoids

Reh Lab:
Autumn, Spring, Winter, Permanent Position

retina, regeneration, stem cells, reprogramming, ESC, brain, transcription, epigenetics, chromatin

Tsukiyama Lab:
All Quarters, Permanent Position

chromatin, transcription, DNA replication, nucleosomes, deep sequencing, bioinformatics, lncRNA, checkpoint, quiescence, chromatin remodeling, histone deacetylation

Wordeman Lab:
Spring

microtubule, kinesin, centromere, centrosome, cytoskeleton, motors

News & Events

Upcoming Event

Currently no scheduled event for Gene Expression, Cell Cycle & Chromosome Biology. Please review the calendar for a full list of upcoming events.

Changes