Genetics, Genomics & Evolution

Pushing the boundaries of genomic technology development, MCB faculty study the organization of genes into genomes and how these change with evolution in systems that range from classic genetic and developmental models all the way to complex human diseases.

Model Curricula

Autumn

CONJ 537
Mechanisms of Transcriptional Regulation

GENOME 553
Advanced Genetic Analysis

MCB 522
The Developmental Basis of Human Disease

MCB 532
Human Pathogenic Viruses

winter

CONJ 544
Protein Structure, Modification and Regulation

spring

MCB 539
Biological Basis of Neoplasia

MCB 543
Logic Constructs and Methodologies of Biological Research

Dr. Mary-Claire King awarded the National Medal of Science by President Obama

Translating genomes

From understanding the genetic basis of familial breast cancer risk to probing hidden parts of the human genome to find the genetic basis of autism and other neurological disorders to understanding the genetic conflicts between host and pathogen genomes, MCB Seattle faculty push the boundries of understanding all aspects of genome biology. The University of Washington ranks #6 in Molecular Biology and Genetics graduate studies according to US News and World Report.

Faculty Area Directors: Celeste Berg, Roger Bumgarner

Student Area Directors: Michelle Hays, Ashley Hall

Lab Openings

Dudley Lab:
All Quarters

Yeast, Genetics, Genomics, Technology Development, Biofilm formation, Antifungal drugs

Wills Lab:
Spring, Winter, Permanent Position

Paredez Lab:
Permanent Position

Giardia, parasite, actin, rac, Rho GTPase, signaling, evolutionary cell biology, cysts, trafficking, cytokinesis, microscopy, biochemistry

Geballe Lab:
Autumn, Spring, Winter

Singhvi Lab:
All Quarters, Permanent Position

glia, neuron, cell signaling, sensory systems

Brewer Lab:
Autumn, Spring, Winter, Permanent Position

Beronja Lab:
All Quarters, Permanent Position

stem cells, progenitor cells, screens, mouse models

Berg Lab:
Spring, Summer, Winter, Permanent Position

development, evolution, patterning, morphogenesis, Drosophila, cell signaling

Disteche Lab:
All Quarters, Permanent Position

epigenetic regulation,chromatin structure,gene regulation,dosage compensation,X chromosome,nuclear structure

Furlong Lab:
Spring

Crowder Lab:
All Quarters, Permanent Position

Hypoxia, genetic screens, C. elegans, drug screens, ischemia, stroke, infarction, cell death, protein misfolding, protein aggregation, mitochondria

MacPherson Lab:
Autumn, Spring, Winter, Permanent Position

mouse models, cancer genetics, targeted therapy

Raible Lab:
All Quarters, Permanent Position

zebrafish, lateral line, hair cell, hearing, deafness, genetics, crispr

Beier Lab:
All Quarters, Permanent Position

Beier DR[Author]

Sherman Lab:
Autumn, Summer, Winter, Permanent Position

Borenstein Lab:
All Quarters, Permanent Position

Sokurenko Lab:
All Quarters, Permanent Position

Fang Lab:
Spring, Permanent Position

Salmonella, Staphylococcus aureus, macrophages, phagocyte, nitric oxide, reactive oxygen species, pathogenesis, bacteria, infection

Ha Lab:
All Quarters, Permanent Position

Cancer genomics, tumor evolution, liquid biopsies, machine learning, copy number alterations, structural variation, circulating tumor DNA

Smith Lab:
All Quarters

Henikoff Lab:
All Quarters, Permanent Position

Chromatin, Transcription, Centromeres, Evolution

Horwitz Lab:
Spring, Summer, Winter, Permanent Position

Genetics, Genomics, Leukemia, Bone Marrow Failure, Cell Fate Maps

Kiem Lab:
All Quarters, Permanent Position

The Kiem Lab studies cell and gene therapy with a particular interest in the biology of blood and marrow stem cells and the development and use of novel genome editing technologies. The overall goal is to develop better stem cell transplant and cell and g

Malik Lab:
Spring, Winter, Permanent Position

centromeres, heterochromatin, Drosophila, viruses, budding yeast, fission yeast, mitochondria, speciation, retroelements, histone variants, Tetrahymena, bacteria, phage, protein, evolution, cytoskeleton, multigene families, histones

Bloom Lab:
All Quarters, Permanent Position

Lee Lab:
All Quarters, Permanent Position

prostate cancer, epithelial transformation, antigen discovery, cellular immunotherapy, small molecule drug discovery

Mullins Lab:
Autumn, Spring, Winter, Permanent Position

hiv, siv, fiv, felv, HHV-8, KSHV, pathogenesis, vaccine, reservoirs, computational biology

Chamberlain Lab:
Autumn, Spring, Winter, Permanent Position

Gene therapy, muscular dystrophy, stem cells, CRISPR/Cas9, AAV vectors, lentiviral vectors, dystrophin, FKRP, DMD, LGMD, genome editing

Kaeberlein Lab:
Autumn, Spring, Winter, Permanent Position

aging, longevity, geroscience, mTOR, rapamycin, sirtuins, mitochondria, hypoxia, hypoxic response, HIF-1, Sir2, TOR, yeast, C. elegans, nematode, mice, dogs

Kerr Lab:
Spring

adaptive landscapes, bacteria, computational model, evolution, experimental evolution, genetics, mathematical model, microbial, phage

Kraemer Lab:
All Quarters, Permanent Position

Amyotrophic lateral sclerosis, Alzheiemer's disease, Frontotemporal Lobar Degeneration Neurodegeneration, tau, TDP-43, protein aggregation, proteostasis

Torii Lab:
Autumn, Spring, Winter, Permanent Position

MacCoss Lab:
All Quarters, Permanent Position

proteomics, protein biochemistry, bioinformatics, technology development, big data, quantitative analysis, model organisms, aging, Alzheimer's disease, mass spectrometry

Ailion Lab:
All Quarters, Permanent Position

C. elegans, neurobiology, genetics, speciation, neuromodulation, G protein, insulin, diabetes, signal transduction, hybrid incompatibility, mitochondria, selfish genes

Dunham Lab:
Autumn, Spring, Winter, Permanent Position

yeast, genomics, genetics, copy number variation, QTL, experimental evolution

King Lab:
Permanent Position

human genetics, cancer genetics, gene discovery, genomics

Emerman Lab:
Autumn, Spring, Winter, Permanent Position

HIV, virology, evolution, innate immunity, restriction factors, lentiviruses, viruses

Merz Lab:
Spring, Summer, Winter, Permanent Position

membrane, cell, organelle, endosome, lysosome, golgi, fusion, SNARE, Rab, tether, biophysics, genetics, yeast, Saccharomyces

Metzger Lab:
All Quarters, Permanent Position

Transmissible cancer, retroelements

Mougous Lab:
All Quarters, Permanent Position

bacteria, microbiome, pathogenesis, signaling, protein secretion, regulation

Myler Lab:
All Quarters, Permanent Position

Pallanck Lab:
All Quarters, Permanent Position

Valdmanis Lab:
All Quarters, Permanent Position

Gene therapy, MicroRNAs, noncoding RNAs, neurogenetics, Amyotrophic Lateral Sclerosis, Alzheimer's disease

Promislow Lab:
All Quarters, Permanent Position

senescence, aging, sexual selection, mating, cost of reproduction, Drosophila, metabolomics, quantitative genetics, theory, systems biology, dogs

Queitsch Lab:
All Quarters, Permanent Position

gene regulation, chaperones, rDNA, microsatellites, STRs, protein folding, sequencing technologies, complex traits, epistasis, Hsp90, heat stress, natural variation, mutation penetrance

Subramaniam Lab:
All Quarters, Permanent Position

computational biology, gene regulation, mrna translation

Bradley Lab:
All Quarters, Permanent Position

RNA splicing, nonsense-mediated decay, myelodysplastic syndromes, leukemia, cancer, muscular dystrophy, FSHD

McLaughlin Lab:
All Quarters, Permanent Position

Genome Evolution, Transposons, Conflict, Viruses, Molecular Evolution, Primates, Mammals, LINE-1, Autoimmunity

Bumgarner Lab:
All Quarters

Bioformatics, host-virus interactions, genomics, expression analysis, microarrays

Risques Lab:
Spring, Summer, Winter

early cancer detection, telomeres, mitochondria, cancer biomarkers, Duplex Sequencing

Salama Lab:
All Quarters, Permanent Position

H. pylori, gastric cancer, bacterial genetics, host-pathogen interactions

Biggins Lab:
All Quarters, Permanent Position

chromosomes, spindle checkpoint, centromere, microtubules, kinetochore, histone variants, tension, aneuploidy

Gibbons Lab:
All Quarters

microbiology, ecology, evolution, bioinformatics, human microbiome

Hahn Lab:
All Quarters, Permanent Position

transcription, gene regulation, genomics, structure, coactivator, RNA polymerase, biochemistry

Saha Lab:
All Quarters, Permanent Position

Stetson Lab:
Autumn, Spring, Winter, Permanent Position

Innate immunity, nucleic acid detection, autoimmune disease,

Davis Lab:
Autumn, Spring, Winter, Permanent Position

mitosis, cell cycle, biochemistry, biophysics, genetics, centrosome, kinetochore, microtubule

Tsukiyama Lab:
All Quarters, Permanent Position

chromatin, transcription, DNA replication, nucleosomes, deep sequencing, bioinformatics, lncRNA, checkpoint, quiescence, chromatin remodeling, histone deacetylation

Kwon Lab:
All Quarters, Permanent Position

systemic organ wasting, cachexia, Hippo signaling pathway, growth, organ communication, metabolism, Drosophila, fruit fly, cancer

News & Events

Upcoming Event

Currently no scheduled event for Genetics, Genomics & Evolution. Please review the calendar for a full list of upcoming events.