Neuroscience

NEURO 501 – Introduction to Neurobiology

Survey of molecular, cellular, and developmental neuroscience, including gene regulation, the cytoskeleton, protein sorting in the secretory pathway, growth factors, and neurotransmitter receptors. Includes lecture discussion of original literature.
Offered AUT, 3.0 credits, Weeks 1-10

NEURO 504 – Biophysics of Nerve, Muscle, and Synapse

Introduces biophysical properties of nerve and muscle cells. Topics include intrinsic electrical properties of neurons, ion channels, receptor signaling, calcium signaling, contraction of muscles, and synaptic function.
Offered AUT, 3.0 credits, Weeks 1-10

NEURO 548 – Molecular Mechanisms of Synaptic Plasticity

Discusses recent primary literature on the molecular mechanisms underlying structural and functional changes of dendritic spines and synapses in the mammalian brain as result of synaptic activity and experience.
Offered SPR, 2.0 credits, Weeks 1-5, Offered even-numbered years

CONJ 531 – Signaling Mechanisms in Excitable Cells

Mechanisms of cellular signaling, particularly in nerve and muscle. Electrical, chemical, and mechanical signaling in the cell that lead to processes such as electrical excitability, action potentials, and muscle contraction. Prerequisite: comprehensive undergraduate course in general biochemistry and molecular biology, or permission of instructor.
Offered AUT, 1.5 credits, Weeks 1-5

CONJ 532 – Signal Transduction from the Cell Membrane to the Nucleus

Intracellular signaling pathways leading from cell membrane receptors to nucleus. Pathways activated by seven transmembrane receptors and G-proteins, insulin/PI3 kinase, MAPKs, and WNTs and mechanisms of signal termination. Cytokine/Jak/Stat signaling and role of subcellular localization in signal transduction.
Offered AUT, 2.0 credits, Weeks 6-10

CONJ 544 – Protein Structure, Modification, and Regulation

Overview of general principles of protein structure, including forces that contribute to folding and stabilization (in week 1), followed by comparative presentation of the primary means by which protein structure and function are studied (NMR, Crystallography, CryoEM and Computational Structure Prediction and modeling) in weeks 2 through 5. The course is intended for molecular and cellular biology student without a background or ongoing research training or experience in structural analyses. The course will introduce students to the basic principles, differences and similarities between different approaches for structural analyses, and will use examples from the recent literature to learn how to evaluate and exploit such studies.
Offered WIN, 1.5 credits, Weeks 1-5, Will be offered in WIN 2023

CONJ 556 – Drug Addiction: Mechanisms, Prevention, and Treatment

Key advances, insights, methods, and challenges for our understanding of drug addiction from psychological, pharmacological, psychiatric, community prevention, legal, and neurodevelopmental perspectives. Enhances familiarity with the multidisciplinary approaches required to understand addiction as a disease.
Offered WIN, 2.0 credits, Weeks 1-10, Offered even-numbered years

NEURO 511 – Seminar in Neurobiology and Behavior

Weekly faculty lectures, student presentations, and discussions of past and current scientific literature in neurobiology and behavior.
Offered AUT, 2.0 credits, Weeks 1-10

PHCOL 534 – Molecular Basis of Addictive Drug Action

Advanced consideration and discussion of current literature addressing the basis of opiate, psychostimulant, and cannabinoid effects on signal transduction events, electrical activity of neurons, and drip-motivated behaviors in animal models of human drug abuse. Prerequisite: PHCOL 512 or permission of instructor.
Offered AUT, 2.0 credits, Weeks 1-10, Offered even-numbered years

PHCOL 537 – Molecular Neurobiology of the Cell Membrane

This graduate level course covers the cell biology of eukaryotic cell membranes and how they contribute to normal functioning and disease. Students will take turns introducing weekly topics and will participate in discussions of 2-3 papers assigned for each class.
Offered WIN, 2.0 credits, Weeks 1-10, Offered odd-numbered years, Will be offered in WIN 2023