faculty

Michael Lagunoff

Lagunoff@uw.edu

University of Washington, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity (Area Director)

Viral oncology

Faculty Contact Information

Building: HSB Room: J-287 Box: 357735 Phone: 206-616-4285 http://microbiology.washington.edu/users/michael-lagunoff

Lab Information

Location: University of Washington Building: Health sciences building, J-wing Room: J-285 Box: 357735 Phone: 221-569 http://microbiology.washington.edu/users/michael-lagunoff

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Quantitative Analysis of the KSHV Transcriptome Following Primary Infection of Blood and Lymphatic Endothelial Cells.

Bruce AG, Barcy S, DiMaio T, Gan E, Garrigues HJ, Lagunoff M, Rose TM.

Pathogens. 2017 Mar 19; 1(6)

Glycolysis, Glutaminolysis, and Fatty Acid Synthesis Are Required for Distinct Stages of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication.

Sanchez EL, Pulliam TH, Dimaio TA, Thalhofer AB, Delgado T, Lagunoff M.

J Virol. 2017 May 15; 10(91)

Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism.

Sychev ZE, Hu A, DiMaio TA, Gitter A, Camp ND, Noble WS, Wolf-Yadlin A, Lagunoff M.

PLoS Pathog. 2017 Mar; 3(13)e1006256

Research Summary

The Lagunoff lab is interested in how viruses cause cancer. Their focus is on Kaposi’s Sarcoma herpesvirus (KSHV), the etiologic agent of Kaposi’s Sarcoma, the most common tumor of AIDS patients and among the most common tumors overall in parts of Sub-Saharan Africa. The lab is interested in how KSHV alters host endothelial cell metabolism, oncogenic signal transduction pathways and the innate immune response to lead to tumor formation.