faculty

Michael MacCoss

maccoss@uw.edu

University of Washington, 

Cancer Biology

Developmental Biology, Stem Cells & Aging

Genetics, Genomics & Evolution

Development and application of proteomics technologies

Faculty Contact Information

Building: Foege Room: S113 Box: 355065 Phone: 206-616-7451 http://maccosslab.org/

Lab Information

Location: University of Washington Building: Foege Room: S111 Phone: 206-616-9023 http://maccosslab.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles.

Thomas RE, Vincow ES, Merrihew GE, MacCoss MJ, Davis MY, Pallanck LJ.

PLoS Genet. 2018 Sep; 9(14)e1007694

Using Skyline to Analyze Data-Containing Liquid Chromatography, Ion Mobility Spectrometry, and Mass Spectrometry Dimensions.

MacLean BX, Pratt BS, Egertson JD, MacCoss MJ, Smith RD, Baker ES.

J Am Soc Mass Spectrom. 2018 Nov; 11(29)2182-2188

Quantitative evolutionary proteomics of seminal fluid from primates with different mating systems.

Claw KG, George RD, MacCoss MJ, Swanson WJ.

BMC Genomics. 2018 Jun 22; 1(19)488

Novel phosphorylation states of the yeast spindle pole body.

Fong KK, Zelter A, Graczyk B, Hoyt JM, Riffle M, Johnson R, MacCoss MJ, Davis TN.

Biol Open. 2018 Oct 8; 10(7)

Research Summary

The focus of our research is in the development of stable isotope and mass spectrometry based approaches to improve our understanding of biology on a molecular, cellular, and whole organism level. Presently, individuals in the laboratory are working on technology for 1) automating biochemical sample preparation methods for the analysis of protein mixtures; 2) increasing the dynamic range of liquid chromatography-mass spectrometry for the analysis of peptides; and 3) developing computational tools for the automated conversion of mass spectrometry data into biologically meaningful results.