faculty

Karol Bomsztyk

karolb@u.washington.edu

University of Washington, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Gene Expression, Cell Cycle & Chromosome Biology

Epigenetic alteration in disease

Faculty Contact Information

Building: UW Medicine SLU Room: Brotman Room 243 Box: 358050 Phone: 206-616-7949 Alt Phone: 206-543-1014

Lab Information

Location: University of Washington Building: UW Medicine SLU Room: Brotman Room 243 Box: Box 358050 Phone: 206-543-1014 Alt Phone: 206-616-4949

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Chromatin changes trigger laminin genes dysregulation in aging kidneys.

Denisenko O, Mar D, Trawczynski M, Bomsztyk K.

Aging (Albany NY). 2018 May 29; 5(10)1133-1145

DNA methylation yields epigenetic clues into the diabetic nephropathy of Pima Indians.

Bomsztyk K, Denisenko O, Wang Y.

Kidney Int. 2018 Jun; 6(93)1272-1275

Engineering a multicellular vascular niche to model hematopoietic cell trafficking.

Kotha SS, Hayes BJ, Phong KT, Redd MA, Bomsztyk K, Ramakrishnan A, Torok-Storb B, Zheng Y.

Stem Cell Res Ther. 2018 Mar 23; 1(9)77

Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy.

Mikula M, Skrzypczak M, Goryca K, Paczkowska K, Ledwon JK, Statkiewicz M, Kulecka M, Grzelak M, Dabrowska M, Kuklinska U, Karczmarski J, Rumienczyk I, Jastrzebski K, Miaczynska M, Ginalski K, Bomsztyk K, Ostrowski J.

Nucleic Acids Res. 2016 Dec 1; 21(44)10150-10164

Research Summary

Detrimental epigenetic processes are emerging as major pathophysiologic culprits of disease including cancer, inflammation, infection and organ injury. These processes involve signaling, transcription and epigenetic factors that regulate gene transcription in the chromatin environment, or the epigenome. To better define epigenetic processes in health and disease, our laboratory has been developing high throughput and sensitivity epigenetic platforms and computational tools and have applied them to study acute organ injury, cancer and inflammation.