faculty

Dave Raible

draible@uw.edu

University of Washington, 

Developmental Biology, Stem Cells & Aging

Genetics, Genomics & Evolution

Neuroscience

Mechanosensory hair cell development, death and regeneration

Faculty Contact Information

Building: Health Sciences Building Room: H-501 Box: Box 357420 Phone: 206-616-1048

Lab Information

Location: University of Washington Building: HSB Room: H-502 Box: Box 357420 http://raibleweb.biostr.washington.edu/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish.

Bhandiwad AA, Raible DW, Rubel EW, Sisneros JA.

J Assoc Res Otolaryngol. 2018 Sep 6;

De novo variants in GREB1L are associated with non-syndromic inner ear malformations and deafness.

Schrauwen I, Kari E, Mattox J, Llaci L, Smeeton J, Naymik M, Raible DW, Knowles JA, Crump JG, Huentelman MJ, Friedman RA.

Hum Genet. 2018 Jul; 6-7(137)459-470

Phenotypic Optimization of Urea-Thiophene Carboxamides To Yield Potent, Well Tolerated, and Orally Active Protective Agents against Aminoglycoside-Induced Hearing Loss.

Chowdhury S, Owens KN, Herr RJ, Jiang Q, Chen X, Johnson G, Groppi VE, Raible DW, Rubel EW, Simon JA.

J Med Chem. 2018 Jan 11; 1(61)84-97

An ancient neurotrophin receptor code; a single Runx/Cbfβ complex determines somatosensory neuron fate specification in zebrafish.

Gau P, Curtright A, Condon L, Raible DW, Dhaka A.

PLoS Genet. 2017 Jul; 7(13)e1006884

Ca<sup>2+</sup>-Permeable AMPARs Mediate Glutamatergic Transmission and Excitotoxic Damage at the Hair Cell Ribbon Synapse.

Sebe JY, Cho S, Sheets L, Rutherford MA, von Gersdorff H, Raible DW.

J Neurosci. 2017 Jun 21; 25(37)6162-6175

Research Summary

Hair cells of the inner ear conver mechanical stimuli to electrical signals transmitted to the brain. Damage and loss of hair cells are leading causes of hearing and balance disorders, affecting over 40 million people in the US. Hair cell loss in humans is irreversible, however they regenerate in other species. We use the zebrafish to study hair cell development, death and regeneration using genetics, genome editing, high resolution imaging and small molecule screening.