faculty

Leo Pallanck

pallanck@uw.edu

University of Washington, 

Developmental Biology, Stem Cells & Aging

Genetics, Genomics & Evolution

Neuroscience

3720 15th Ave NE

Faculty Contact Information

Building: WH Foege Room: S-443 Box: 355065 Phone: 206-616-5997 Alt Phone: 206-616-5996

Lab Information

Location: University of Washington Building: WH Foege Room: s-443 Box: 355065 Phone: 206-616-5996

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Glucocerebrosidase deficiency promotes protein aggregation through dysregulation of extracellular vesicles.

Thomas RE, Vincow ES, Merrihew GE, MacCoss MJ, Davis MY, Pallanck LJ.

PLoS Genet. 2018 Sep; 9(14)e1007694

A mitochondrial DNA hypomorph of cytochrome oxidase specifically impairs male fertility in Drosophila melanogaster.

Patel MR, Miriyala GK, Littleton AJ, Yang H, Trinh K, Young JM, Kennedy SR, Yamashita YM, Pallanck LJ, Malik HS.

Elife. 2016 Aug 2; (5)

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration.

Davis MY, Trinh K, Thomas RE, Yu S, Germanos AA, Whitley BN, Sardi SP, Montine TJ, Pallanck LJ.

PLoS Genet. 2016 Mar; 3(12)e1005944

A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer.

Burman JL, Itsara LS, Kayser EB, Suthammarak W, Wang AM, Kaeberlein M, Sedensky MM, Morgan PG, Pallanck LJ.

Dis Model Mech. 2014 Oct; 10(7)1165-74

Research Summary

Mitochondrial dysfunction and protein aggregation are common neuropathological features of aging and neurodegenerative disease. My laboratory uses Drosophila to study these matters. In particular, we are interested in how damaged mitochondria are detected and degraded, whether there is selection against harmful mtDNA mutations, and how protein aggregates spread between tissues. We use genetic, genomic, proteomic and computational approaches to study these matters, thus offering multidisciplinary training opportunities for students interested in these problems.