Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Genetics and Genomics of Cancer
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We study several inter-related aspects of cancer biology. We seek to identify and understand the role of key somatic genomic alterations that drive cancer development, metastasis (with organ tropism), and therapy resistance. A second area of focus involves determining influences of the tumor microenvironment on cancer cell behavior. A third area of focus centers on determining the roles of hormones and nuclear hormone receptors as lineage oncogenes, with a particular emphasis on cancer of the prostate, the most common cancer affecting men.