faculty

Michael Emerman

memerman@fredhutch.org

Fred Hutch, 

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

HIV replication and host antiviral genes

Faculty Contact Information

Building: Hutchinson Building Room: C2-019 Box: C2-023 Phone: 206-667-5058 http://research.fhcrc.org/emerman/en.html

Lab Information

Location: Fred Htuch Building: Hutchinson Building Room: C2-187 Box: C2-023 Phone: 206-667-5754 http://research.fhcrc.org/emerman/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Recurrent Loss of APOBEC3H Activity during Primate Evolution.

Garcia EI, Emerman M.

J Virol. 2018 Jun 20;

Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.

Baldauf HM, Stegmann L, Schwarz SM, Ambiel I, Trotard M, Martin M, Burggraf M, Lenzi GM, Lejk H, Pan X, Fregoso OI, Lim ES, Abraham L, Nguyen LA, Rutsch F, König R, Kim B, Emerman M, Fackler OT, Keppler OT.

Proc Natl Acad Sci U S A. 2017 Mar 7; 10(114)2729-2734

Cytidine deaminase efficiency of the lentiviral viral restriction factor APOBEC3C correlates with dimerization.

Adolph MB, Ara A, Feng Y, Wittkopp CJ, Emerman M, Fraser JS, Chelico L.

Nucleic Acids Res. 2017 Apr 7; 6(45)3378-3394

A Single Nucleotide Polymorphism in Human APOBEC3C Enhances Restriction of Lentiviruses.

Wittkopp CJ, Adolph MB, Wu LI, Chelico L, Emerman M.

PLoS Pathog. 2016 Oct; 10(12)e1005865

Research Summary

The Emerman lab studies host-cell interactions of the human immunodeficiency virus (HIV) and related viruses. We wish to understand the molecular and evolutionary basis of virus replication and pathogenesis. We study the evolution and function of host antiviral genes in order to determine how HIV adapted to humans, and how ancient viral infections influenced the susceptibility or resistance of humans to modern lentiviruses.