Sandra Bajjalieh
bajjalie@uw.eduUniversity of Washington,
Cell Signaling & Cell/Environment Interactions (Area Director)
Neuroscience
Cell biology of neurons
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
Synaptic vesicle protein 2: A multi-faceted regulator of secretion.
Ciruelas K, Marcotulli D, Bajjalieh SM.
Semin Cell Dev Biol. 2019 Mar 20;
Correction to: A statistical framework for analyzing deep mutational scanning data.
Rubin AF, Gelman H, Lucas N, Bajjalieh SM, Papenfuss AT, Speed TP, Fowler DM.
Genome Biol. 2018 Feb 7; 1(19)17
A statistical framework for analyzing deep mutational scanning data.
Rubin AF, Gelman H, Lucas N, Bajjalieh SM, Papenfuss AT, Speed TP, Fowler DM.
Genome Biol. 2017 Aug 7; 1(18)150
Characterization of the Functional Domains of a Mammalian Voltage-Sensitive Phosphatase.
Rosasco MG, Gordon SE, Bajjalieh SM.
Biophys J. 2015 Dec 15; 12(109)2480-2491
Kaempf N, Kochlamazashvili G, Puchkov D, Maritzen T, Bajjalieh SM, Kononenko NL, Haucke V.
Proc Natl Acad Sci U S A. 2015 Jun 9; 23(112)7297-302
Huntingtin is associated with cytomatrix proteins at the presynaptic terminal.
Yao J, Ong SE, Bajjalieh S.
Mol Cell Neurosci. 2014 Nov; (63)96-100
Laßek M, Weingarten J, Acker-Palmer A, Bajjalieh SM, Muller U, Volknandt W.
Curr Alzheimer Res. 2014; 10(11)971-80
Loss of the SV2-like protein SVOP produces no apparent deficits in laboratory mice.
Yao J, de la Iglesia HO, Bajjalieh SM.
PLoS One. 2013; 7(8)e68215
Single-axonal organelle analysis method reveals new protein-motor associations.
Sgro AE, Bajjalieh SM, Chiu DT.
ACS Chem Neurosci. 2013 Feb 20; 2(4)277-84
Single-molecule fluorescence quantification with a photobleached internal standard.
Gadd JC, Fujimoto BS, Bajjalieh SM, Chiu DT.
Anal Chem. 2012 Dec 18; 24(84)10522-5
Levetiracetam reverses synaptic deficits produced by overexpression of SV2A.
Nowack A, Malarkey EB, Yao J, Bleckert A, Hill J, Bajjalieh SM.
PLoS One. 2011; 12(6)e29560
Determining the number of specific proteins in cellular compartments by quantitative microscopy.
Mutch SA, Gadd JC, Fujimoto BS, Kensel-Hammes P, Schiro PG, Bajjalieh SM, Chiu DT.
Nat Protoc. 2011 Nov 17; 12(6)1953-68
Measurements of the acidification kinetics of single SynaptopHluorin vesicles.
Budzinski KL, Zeigler M, Fujimoto BS, Bajjalieh SM, Chiu DT.
Biophys J. 2011 Oct 5; 7(101)1580-9
A high-throughput method for generating uniform microislands for autaptic neuronal cultures.
Sgro AE, Nowak AL, Austin NS, Custer KL, Allen PB, Chiu DT, Bajjalieh SM.
J Neurosci Methods. 2011 Jun 15; 2(198)230-5
Mutch SA, Kensel-Hammes P, Gadd JC, Fujimoto BS, Allen RW, Schiro PG, Lorenz RM, Kuyper CL, Kuo JS, Bajjalieh SM, Chiu DT.
J Neurosci. 2011 Jan 26; 4(31)1461-70
SV2 regulates neurotransmitter release via multiple mechanisms.
Nowack A, Yao J, Custer KL, Bajjalieh SM.
Am J Physiol Cell Physiol. 2010 Nov; 5(299)C960-7
Cotrafficking of SV2 and synaptotagmin at the synapse.
Yao J, Nowack A, Kensel-Hammes P, Gardner RG, Bajjalieh SM.
J Neurosci. 2010 Apr 21; 16(30)5569-78
Large structural change in isolated synaptic vesicles upon loading with neurotransmitter.
Budzinski KL, Allen RW, Fujimoto BS, Kensel-Hammes P, Belnap DM, Bajjalieh SM, Chiu DT.
Biophys J. 2009 Nov 4; 9(97)2577-84
Morgans CW, Kensel-Hammes P, Hurley JB, Burton K, Idzerda R, McKnight GS, Bajjalieh SM.
PLoS One. 2009; 4(4)e5230
Synaptic vesicle protein 2 binds adenine nucleotides.
Yao J, Bajjalieh SM.
J Biol Chem. 2008 Jul 25; 30(283)20628-34
The heterotrimeric [corrected] G protein subunit G alpha i is present on mitochondria.
Lyssand JS, Bajjalieh SM.
FEBS Lett. 2007 Dec 22; 30(581)5765-8
Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase.
Epand RM, Shulga YV, Timmons HC, Perri AL, Belani JD, Perinpanathan K, Johnson-McIntire LB, Bajjalieh S, Dicu AO, Elias C, Rychnovsky SD, Topham MK.
Biochemistry. 2007 Dec 11; 49(46)14225-31
Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells.
Muccioli GG, Xu C, Odah E, Cudaback E, Cisneros JA, Lambert DM, López Rodríguez ML, Bajjalieh S, Stella N.
J Neurosci. 2007 Mar 14; 11(27)2883-9
Deconvolving single-molecule intensity distributions for quantitative microscopy measurements.
Mutch SA, Fujimoto BS, Kuyper CL, Kuo JS, Bajjalieh SM, Chiu DT.
Biophys J. 2007 Apr 15; 8(92)2926-43
Synaptic vesicle protein 2 enhances release probability at quiescent synapses.
Custer KL, Austin NS, Sullivan JM, Bajjalieh SM.
J Neurosci. 2006 Jan 25; 4(26)1303-13
SV2A and SV2C contain a unique synaptotagmin-binding site.
Schivell AE, Mochida S, Kensel-Hammes P, Custer KL, Bajjalieh SM.
Mol Cell Neurosci. 2005 May; 1(29)56-64
MuLK, a eukaryotic multi-substrate lipid kinase.
Waggoner DW, Johnson LB, Mann PC, Morris V, Guastella J, Bajjalieh SM.
J Biol Chem. 2004 Sep 10; 37(279)38228-35
The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam.
Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B.
Proc Natl Acad Sci U S A. 2004 Jun 29; 26(101)9861-6
SNAREs take the stage: a prime time to trigger neurotransmitter secretion.
Bajjalieh S
Trends Neurosci. 2001 Dec; 12(24)678-80
SV2 modulates the size of the readily releasable pool of secretory vesicles.
Xu T, Bajjalieh SM.
Nat Cell Biol. 2001 Aug; 8(3)691-8
Phosphorylation of synaptic vesicle protein 2 modulates binding to synaptotagmin.
Pyle RA, Schivell AE, Hidaka H, Bajjalieh SM.
J Biol Chem. 2000 Jun 2; 22(275)17195-200
Abnormal neurotransmission in mice lacking synaptic vesicle protein 2A (SV2A).
Crowder KM, Gunther JM, Jones TA, Hale BD, Zhang HZ, Peterson MR, Scheller RH, Chavkin C, Bajjalieh SM.
Proc Natl Acad Sci U S A. 1999 Dec 21; 26(96)15268-73
Schivell AE, Batchelor RH, Bajjalieh SM.
J Biol Chem. 1996 Nov 1; 44(271)27770-5
The biochemistry of neurotransmitter secretion.
Bajjalieh SM, Scheller RH.
J Biol Chem. 1995 Feb 3; 5(270)1971-4
Differential expression of synaptic vesicle protein 2 (SV2) isoforms.
Bajjalieh SM, Frantz GD, Weimann JM, McConnell SK, Scheller RH.
J Neurosci. 1994 Sep; 9(14)5223-35
Synaptic vesicle proteins and exocytosis.
Bajjalieh SM, Scheller RH.
Adv Second Messenger Phosphoprotein Res. 1994; (29)59-79
Ceramide 1-phosphate phosphatase activity in brain.
Shinghal R, Scheller RH, Bajjalieh SM.
J Neurochem. 1993 Dec; 6(61)2279-85
Brain contains two forms of synaptic vesicle protein 2.
Bajjalieh SM, Peterson K, Linial M, Scheller RH.
Proc Natl Acad Sci U S A. 1993 Mar 15; 6(90)2150-4
SV2, a brain synaptic vesicle protein homologous to bacterial transporters.
Bajjalieh SM, Peterson K, Shinghal R, Scheller RH.
Science. 1992 Aug 28; 5074(257)1271-3
Bajjalieh SM, Martin TF, Floor E.
J Biol Chem. 1989 Aug 25; 24(264)14354-60
Martin TF, Bajjalieh SM, Lucas DO, Kowalchyk JA.
J Biol Chem. 1986 Aug 5; 22(261)10141-9
Martin TF, Lucas DO, Bajjalieh SM, Kowalchyk JA.
J Biol Chem. 1986 Feb 25; 6(261)2918-27
Lucas DO, Bajjalieh SM, Kowalchyk JA, Martin TF.
Biochem Biophys Res Commun. 1985 Oct 30; 2(132)721-8
Research Summary
We develop and utilize biochemical and cell biological approaches to study how protein and lipid interactions mediate the highly regulated secretion of neurotransmitters.