John Scott
scottjdw@uw.eduUniversity of Washington,
Cell Signaling & Cell/Environment Interactions
Signal transduction events that are controlled by anchoring proteins
Faculty Contact Information
Lab Information
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Publications
The following publications were retrieved from PubMed:
Turnham RE, Smith FD, Kenerson HL, Omar MH, Golkowski M, Garcia I, Bauer R, Lau HT, Sullivan KM, Langeberg LK, Ong SE, Riehle KJ, Yeung RS, Scott JD.
Elife. 2019 May 7; (8)
Road map for fibrolamellar carcinoma: progress and goals of a diversified approach.
Kastenhuber ER, Craig J, Ramsey J, Sullivan KM, Sage J, de Oliveira S, Riehle KJ, Scott JD, Gordan JD, Bardeesy N, Abou-Alfa GK.
J Hepatocell Carcinoma. 2019; (6)41-48
Young JD, Abdel-Massih R, Herchline T, McCurdy L, Moyer KJ, Scott JD, Wood BR, Siddiqui J.
Clin Infect Dis. 2019 Mar 9;
MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma.
Dinh TA, Jewell ML, Kanke M, Francisco A, Sritharan R, Turnham RE, Lee S, Kastenhuber ER, Wauthier E, Guy CD, Yeung RS, Lowe SW, Reid LM, Scott JD, Diehl AM, Sethupathy P.
Cell Mol Gastroenterol Hepatol. 2019; 4(7)803-817
Tsui JI, Miller CM, Scott JD, Corcorran MA, Dombrowski JC, Glick SN.
Drug Alcohol Depend. 2019 Feb 1; (195)114-120
Aggarwal S, Gabrovsek L, Langeberg LK, Golkowski M, Ong SE, Smith FD, Scott JD.
J Biol Chem. 2019 Mar 1; 9(294)3152-3168
Smith FD, Omar MH, Nygren PJ, Soughayer J, Hoshi N, Lau HT, Snyder CG, Branon TC, Ghosh D, Langeberg LK, Ting AY, Santana LF, Ong SE, Navedo MF, Scott JD.
Proc Natl Acad Sci U S A. 2018 Dec 4; 49(115)E11465-E11474
Wood BR, Mann MS, Martinez-Paz N, Unruh KT, Annese M, Spach DH, Scott JD, Stekler JD.
Sex Health. 2018 Nov; 6(15)601-605
Protein kinase A activation: Something new under the sun?
Smith FD, Scott JD.
J Cell Biol. 2018 Jun 4; 6(217)1895-1897
Sanderson JL, Scott JD, Dell'Acqua ML.
J Neurosci. 2018 Mar 14; 11(38)2863-2876
Using an Innovative Telehealth Model to Support Community Providers Who Deliver Perinatal HIV Care.
Ness TE, Annese MF, Martinez-Paz N, Unruh KT, Scott JD, Wood BR.
AIDS Educ Prev. 2017 Dec; 6(29)516-526
HIV Pre-exposure Prophylaxis Prescribing Through Telehealth.
Stekler JD, McMahan V, Ballinger L, Viquez L, Swanson F, Stockton J, Crutsinger-Perry B, Kern D, Scott JD.
J Acquir Immune Defic Syndr. 2018 Apr 15; 5(77)e40-e42
Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD.
Elife. 2017 Oct 2; (6)
Barriers to Treatment Access for Chronic Hepatitis C Virus Infection: A Case Series.
Millman AJ, Ntiri-Reid B, Irvin R, Kaufmann MH, Aronsohn A, Duchin JS, Scott JD, Vellozzi C.
Top Antivir Med. 2017 Jul/Aug; 3(25)110-113
What is the impact of treatment for hepatitis C virus infection?
Wiktor SZ, Scott JD.
Lancet. 2017 Jul 8; 10090(390)107-109
Local protein kinase A action proceeds through intact holoenzymes.
Smith FD, Esseltine JL, Nygren PJ, Veesler D, Byrne DP, Vonderach M, Strashnov I, Eyers CE, Eyers PA, Langeberg LK, Scott JD.
Science. 2017 Jun 23; 6344(356)1288-1293
Pseudoscaffolds and anchoring proteins: the difference is in the details.
Aggarwal-Howarth S, Scott JD.
Biochem Soc Trans. 2017 Apr 15; 2(45)371-379
Nystoriak MA, Nieves-Cintrón M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F, Sasse KC, Scott JD, Ward SM, Hell JW, Navedo MF.
Sci Signal. 2017 Jan 24; 463(10)
Siddiqui J, Herchline T, Kahlon S, Moyer KJ, Scott JD, Wood BR, Young J.
Clin Infect Dis. 2017 Feb 1; 3(64)237-242
Regulation of the phosphatase PP2B by protein-protein interactions.
Nygren PJ, Scott JD.
Biochem Soc Trans. 2016 Oct 15; 5(44)1313-1319
Li L, Li J, Drum BM, Chen Y, Yin H, Guo X, Luckey SW, Gilbert ML, McKnight GS, Scott JD, Santana LF, Liu Q.
Cardiovasc Res. 2017 Feb; 2(113)147-159
Wood BR, Unruh KT, Martinez-Paz N, Annese M, Ramers CB, Harrington RD, Dhanireddy S, Kimmerly L, Scott JD, Spach DH.
Open Forum Infect Dis. 2016 Sep; 3(3)ofw123
Malonate in the nucleotide-binding site traps human AKAP18γ/δ in a novel conformational state.
Bjerregaard-Andersen K, Østensen E, Scott JD, Taskén K, Morth JP.
Acta Crystallogr F Struct Biol Commun. 2016 Aug; Pt 8(72)591-7
Newton AC, Bootman MD, Scott JD.
Cold Spring Harb Perspect Biol. 2016 Aug 1; 8(8)
Whiting JL, Ogier L, Forbush KA, Bucko P, Gopalan J, Seternes OM, Langeberg LK, Scott JD.
Proc Natl Acad Sci U S A. 2016 Jul 26; 30(113)E4328-37
Endogenous N-terminal Domain Cleavage Modulates α1D-Adrenergic Receptor Pharmacodynamics.
Kountz TS, Lee KS, Aggarwal-Howarth S, Curran E, Park JM, Harris DA, Stewart A, Hendrickson J, Camp ND, Wolf-Yadlin A, Wang EH, Scott JD, Hague C.
J Biol Chem. 2016 Aug 26; 35(291)18210-21
Cherry AE, Haas BR, Naydenov AV, Fung S, Xu C, Swinney K, Wagenbach M, Freeling J, Canton DA, Coy J, Horne EA, Rickman B, Vicente JJ, Scott JD, Ho RJ, Liggitt D, Wordeman L, Stella N.
Mol Cancer Ther. 2016 Sep; 9(15)2018-29
Bacterial spore coat protein kinases: A new twist to an old story.
Scott JD, Newton AC.
Proc Natl Acad Sci U S A. 2016 Jun 21; 25(113)6811-2
Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.
Riggle KM, Riehle KJ, Kenerson HL, Turnham R, Homma MK, Kazami M, Samelson B, Bauer R, McKnight GS, Scott JD, Yeung RS.
Pediatr Res. 2016 Jul; 1(80)110-8
Fibrolamellar Hepatocellular Carcinoma: Mechanistic Distinction From Adult Hepatocellular Carcinoma.
Riggle KM, Turnham R, Scott JD, Yeung RS, Riehle KJ.
Pediatr Blood Cancer. 2016 Jul; 7(63)1163-7
Nieves-Cintrón M, Hirenallur-Shanthappa D, Nygren PJ, Hinke SA, Dell'Acqua ML, Langeberg LK, Navedo M, Santana LF, Scott JD.
Cell Signal. 2016 Jul; 7(28)733-40
Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology.
Turnham RE, Scott JD.
Gene. 2016 Feb 15; 2(577)101-8
Hehnly H, Canton D, Bucko P, Langeberg LK, Ogier L, Gelman I, Santana LF, Wordeman L, Scott JD.
Elife. 2015 Sep 25; (4)e09384
Nygren PJ, Scott JD.
Front Pharmacol. 2015; (6)158
Whiting JL, Nygren PJ, Tunquist BJ, Langeberg LK, Seternes OM, Scott JD.
J Biol Chem. 2015 Aug 7; 32(290)19445-57
A-kinase Anchoring Protein 79/150 Recruits Protein Kinase C to Phosphorylate Roundabout Receptors.
Samelson BK, Gore BB, Whiting JL, Nygren PJ, Purkey AM, Colledge M, Langeberg LK, Dell'Acqua ML, Zweifel LS, Scott JD.
J Biol Chem. 2015 May 29; 22(290)14107-19
Signalling scaffolds and local organization of cellular behaviour.
Langeberg LK, Scott JD.
Nat Rev Mol Cell Biol. 2015 Apr; 4(16)232-44
PKA-type I selective constrained peptide disruptors of AKAP complexes.
Wang Y, Ho TG, Franz E, Hermann JS, Smith FD, Hehnly H, Esseltine JL, Hanold LE, Murph MM, Bertinetti D, Scott JD, Herberg FW, Kennedy EJ.
ACS Chem Biol. 2015 Jun 19; 6(10)1502-10
Selective down-regulation of KV2.1 function contributes to enhanced arterial tone during diabetes.
Nieves-Cintrón M, Nystoriak MA, Prada MP, Johnson K, Fayer W, Dell'Acqua ML, Scott JD, Navedo MF.
J Biol Chem. 2015 Mar 20; 12(290)7918-29
Lawitz E, Sulkowski MS, Ghalib R, Rodriguez-Torres M, Younossi ZM, Corregidor A, DeJesus E, Pearlman B, Rabinovitz M, Gitlin N, Lim JK, Pockros PJ, Scott JD, Fevery B, Lambrecht T, Ouwerkerk-Mahadevan S, Callewaert K, Symonds WT, Picchio G, Lindsay KL, Beumont M, Jacobson IM.
Lancet. 2014 Nov 15; 9956(384)1756-65
Sonkusare SK, Dalsgaard T, Bonev AD, Hill-Eubanks DC, Kotlikoff MI, Scott JD, Santana LF, Nelson MT.
Sci Signal. 2014 Jul 8; 333(7)ra66
Murphy JG, Sanderson JL, Gorski JA, Scott JD, Catterall WA, Sather WA, Dell'Acqua ML.
Cell Rep. 2014 Jun 12; 5(7)1577-1588
Local control of TRPV4 channels by AKAP150-targeted PKC in arterial smooth muscle.
Mercado J, Baylie R, Navedo MF, Yuan C, Scott JD, Nelson MT, Brayden JE, Santana LF.
J Gen Physiol. 2014 May; 5(143)559-75
E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis.
Pruneda JN, Smith FD, Daurie A, Swaney DL, Villén J, Scott JD, Stadnyk AW, Le Trong I, Stenkamp RE, Klevit RE, Rohde JR, Brzovic PS.
EMBO J. 2014 Mar 3; 5(33)437-49
Nystoriak MA, Nieves-Cintrón M, Nygren PJ, Hinke SA, Nichols CB, Chen CY, Puglisi JL, Izu LT, Bers DM, Dell'acqua ML, Scott JD, Santana LF, Navedo MF.
Circ Res. 2014 Feb 14; 4(114)607-15
AKAP signaling complexes: pointing towards the next generation of therapeutic targets?
Esseltine JL, Scott JD.
Trends Pharmacol Sci. 2013 Dec; 12(34)648-55
Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation.
Smith FD, Reichow SL, Esseltine JL, Shi D, Langeberg LK, Scott JD, Gonen T.
Elife. 2013 Nov 5; (2)e01319
Scaffolding proteins: not such innocent bystanders.
Smith FD, Scott JD.
Curr Biol. 2013 Jun 17; 12(23)R515-7
Direct-acting antiviral-associated dermatitis during chronic hepatitis C virus treatment.
Biesbroeck LK, Scott JD, Taraska C, Moore E, Falsey RR, Shinohara MM.
Am J Clin Dermatol. 2013 Dec; 6(14)497-502
Gold MG, Fowler DM, Means CK, Pawson CT, Stephany JJ, Langeberg LK, Fields S, Scott JD.
J Biol Chem. 2013 Jun 14; 24(288)17111-21
Scott JD, Unruh KT, Catlin MC, Merrill JO, Tauben DJ, Rosenblatt R, Buchwald D, Doorenbos A, Towle C, Ramers CB, Spacha DH.
J Telemed Telecare. 2012 Dec; 8(18)481-4
A-kinase-anchoring protein-Lbc connects stress signaling to cardiac hypertrophy.
Smith FD, Scott JD.
Mol Cell Biol. 2013 Jan; 1(33)2-3
Gravin is a transitory effector of polo-like kinase 1 during cell division.
Canton DA, Keene CD, Swinney K, Langeberg LK, Nguyen V, Pelletier L, Pawson T, Wordeman L, Stella N, Scott JD.
Mol Cell. 2012 Nov 30; 4(48)547-59
Allele-specific PCR for determination of IL28B genotype.
Cook L, Diem K, Kim W, Scott JD, Jerome KR.
J Clin Microbiol. 2012 Dec; 12(50)4144-6
Creating order from chaos: cellular regulation by kinase anchoring.
Scott JD, Dessauer CW, Taskén K.
Annu Rev Pharmacol Toxicol. 2013; (53)187-210
Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.
Jones BW, Brunet S, Gilbert ML, Nichols CB, Su T, Westenbroek RE, Scott JD, Catterall WA, McKnight GS.
Proc Natl Acad Sci U S A. 2012 Oct 16; 42(109)17099-104
Anchored phosphatases modulate glucose homeostasis.
Hinke SA, Navedo MF, Ulman A, Whiting JL, Nygren PJ, Tian G, Jimenez-Caliani AJ, Langeberg LK, Cirulli V, Tengholm A, Dell'Acqua ML, Santana LF, Scott JD.
EMBO J. 2012 Oct 17; 20(31)3991-4004
Ioannou GN, Bryson CL, Weiss NS, Miller R, Scott JD, Boyko EJ.
Hepatology. 2013 Jan; 1(57)249-57
Cost-effectiveness and population outcomes of general population screening for hepatitis C.
Coffin PO, Scott JD, Golden MR, Sullivan SD.
Clin Infect Dis. 2012 May; 9(54)1259-71
A summary of the 18th International Symposium on Hepatitis C Virus and Related Viruses.
Polyak SJ, Morishima C, Scott JD, Gastaminza P, Cox A, de Araújo ES, Higgs MR, Loo YM, Golden-Mason L, Lindenbach BD, Baumert TF, Randall G, Gale M Jr.
Gastroenterology. 2012 Jan; 1(142)e1-5
AKAP2 anchors PKA with aquaporin-0 to support ocular lens transparency.
Gold MG, Reichow SL, O'Neill SE, Weisbrod CR, Langeberg LK, Bruce JE, Gonen T, Scott JD.
EMBO Mol Med. 2012 Jan; 1(4)15-26
Means CK, Lygren B, Langeberg LK, Jain A, Dixon RE, Vega AL, Gold MG, Petrosyan S, Taylor SS, Murphy AN, Ha T, Santana LF, Tasken K, Scott JD.
Proc Natl Acad Sci U S A. 2011 Nov 29; 48(108)E1227-35
AKAP220 protein organizes signaling elements that impact cell migration.
Logue JS, Whiting JL, Tunquist B, Sacks DB, Langeberg LK, Wordeman L, Scott JD.
J Biol Chem. 2011 Nov 11; 45(286)39269-81
Sequestering Rac with PKA confers cAMP control of cytoskeletal remodeling.
Logue JS, Whiting JL, Scott JD.
Small GTPases. 2011 May; 3(2)173-176
Cheng EP, Yuan C, Navedo MF, Dixon RE, Nieves-Cintrón M, Scott JD, Santana LF.
Circ Res. 2011 Jul 22; 3(109)255-61
Patient acceptance of universal screening for hepatitis C virus infection.
Coffin PO, Stevens AM, Scott JD, Stekler JD, Golden MR.
BMC Infect Dis. 2011 Jun 6; (11)160
Discovery of cellular substrates for protein kinase A using a peptide array screening protocol.
Smith FD, Samelson BK, Scott JD.
Biochem J. 2011 Aug 15; 1(438)103-10
Buskin SE, Barash EA, Scott JD, Aboulafia DM, Wood RW.
World J Gastroenterol. 2011 Apr 14; 14(17)1807-16
Architecture and dynamics of an A-kinase anchoring protein 79 (AKAP79) signaling complex.
Gold MG, Stengel F, Nygren PJ, Weisbrod CR, Bruce JE, Robinson CV, Barford D, Scott JD.
Proc Natl Acad Sci U S A. 2011 Apr 19; 16(108)6426-31
Anchored protein kinase A recruitment of active Rac GTPase.
Logue JS, Whiting JL, Tunquist B, Langeberg LK, Scott JD.
J Biol Chem. 2011 Jun 24; 25(286)22113-21
Diagnosis of depression in former injection drug users with chronic hepatitis C.
Scott JD, Wang CC, Coppel E, Lau A, Veitengruber J, Roy-Byrne P.
J Clin Gastroenterol. 2011 May-Jun; 5(45)462-7
Lyssand JS, Whiting JL, Lee KS, Kastl R, Wacker JL, Bruchas MR, Miyatake M, Langeberg LK, Chavkin C, Scott JD, Gardner RG, Adams ME, Hague C.
Proc Natl Acad Sci U S A. 2010 Dec 14; 50(107)21854-9
AKAP-Lbc enhances cyclic AMP control of the ERK1/2 cascade.
Smith FD, Langeberg LK, Cellurale C, Pawson T, Morrison DK, Davis RJ, Scott JD.
Nat Cell Biol. 2010 Dec; 12(12)1242-9
Chk-ing in and Chk-ing out: kinase compartmentalization comes to checkpoint control.
Canton DA, Scott JD.
Mol Cell. 2010 Oct 8; 1(40)1-2
Organizing signal transduction through A-kinase anchoring proteins (AKAPs).
Logue JS, Scott JD.
FEBS J. 2010 Nov; 21(277)4370-5
Signal integration through blending, bolstering and bifurcating of intracellular information.
Pawson CT, Scott JD.
Nat Struct Mol Biol. 2010 Jun; 6(17)653-8
Networking with AKAPs: context-dependent regulation of anchored enzymes.
Welch EJ, Jones BW, Scott JD.
Mol Interv. 2010 Apr; 2(10)86-97
A-kinase anchoring proteins: getting to the heart of the matter.
Scott JD, Santana LF.
Circulation. 2010 Mar 16; 10(121)1264-71
Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome.
Navedo MF, Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, Santana LF.
Circ Res. 2010 Mar 5; 4(106)748-56
Retrospective. Edwin G. Krebs (1918-2009).
Catterall WA, Scott JD.
Science. 2010 Jan 29; 5965(327)537
Cell signaling in space and time: where proteins come together and when they're apart.
Scott JD, Pawson T.
Science. 2009 Nov 27; 5957(326)1220-4
Hepatitis C virus is infrequently evaluated and treated in an urban HIV clinic population.
Scott JD, Wald A, Kitahata M, Krantz E, Drolette L, Corey L, Wang CC.
AIDS Patient Care STDS. 2009 Nov; 11(23)925-9
A-kinase anchoring proteins: from protein complexes to physiology and disease.
Carnegie GK, Means CK, Scott JD.
IUBMB Life. 2009 Apr; 4(61)394-406
Role of combination therapy in chronic hepatitis B.
Scott JD, McMahon B.
Curr Gastroenterol Rep. 2009 Feb; 1(11)28-36
mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha.
Wong W, Goehring AS, Kapiloff MS, Langeberg LK, Scott JD.
Sci Signal. 2008 Dec 23; 51(1)ra18
AKAP-Lbc mobilizes a cardiac hypertrophy signaling pathway.
Carnegie GK, Soughayer J, Smith FD, Pedroja BS, Zhang F, Diviani D, Bristow MR, Kunkel MT, Newton AC, Langeberg LK, Scott JD.
Mol Cell. 2008 Oct 24; 2(32)169-79
Loss of AKAP150 perturbs distinct neuronal processes in mice.
Tunquist BJ, Hoshi N, Guire ES, Zhang F, Mullendorff K, Langeberg LK, Raber J, Scott JD.
Proc Natl Acad Sci U S A. 2008 Aug 26; 34(105)12557-62
Chronic liver disease in Aboriginal North Americans.
Scott JD, Garland N.
World J Gastroenterol. 2008 Aug 7; 29(14)4607-15
MyRIP anchors protein kinase A to the exocyst complex.
Goehring AS, Pedroja BS, Hinke SA, Langeberg LK, Scott JD.
J Biol Chem. 2007 Nov 9; 45(282)33155-67
A-kinase anchoring proteins take shape.
Beene DL, Scott JD.
Curr Opin Cell Biol. 2007 Apr; 2(19)192-8
Molecular diagnostics of hepatitis C virus infection: a systematic review.
Scott JD, Gretch DR.
JAMA. 2007 Feb 21; 7(297)724-32
A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory.
Soderling SH, Guire ES, Kaech S, White J, Zhang F, Schutz K, Langeberg LK, Banker G, Raber J, Scott JD.
J Neurosci. 2007 Jan 10; 2(27)355-65
Dynamic regulation of cAMP synthesis through anchored PKA-adenylyl cyclase V/VI complexes.
Bauman AL, Soughayer J, Nguyen BT, Willoughby D, Carnegie GK, Wong W, Hoshi N, Langeberg LK, Cooper DM, Dessauer CW, Scott JD.
Mol Cell. 2006 Sep 15; 6(23)925-31
AKAP signaling complexes: getting to the heart of the matter.
McConnachie G, Langeberg LK, Scott JD.
Trends Mol Med. 2006 Jul; 7(12)317-23
The where's and when's of kinase anchoring.
Smith FD, Langeberg LK, Scott JD.
Trends Biochem Sci. 2006 Jun; 6(31)316-23
Smith FD, Scott JD.
Eur J Cell Biol. 2006 Jul; 7(85)585-92
Scott JD, McMahon BJ, Bruden D, Sullivan D, Homan C, Christensen C, Gretch DR.
Clin Infect Dis. 2006 Apr 1; 7(42)945-52
Contextual utilization of enzymes in discrete AKAP79/150 signalling complexes.
Hoshi N, Scott JD.
Eur J Cell Biol. 2006 Jul; 7(85)621-2
Spatial restriction of PDK1 activation cascades by anchoring to mAKAPalpha.
Michel JJ, Townley IK, Dodge-Kafka KL, Zhang F, Kapiloff MS, Scott JD.
Mol Cell. 2005 Dec 9; 5(20)661-72
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity.
Hoshi N, Langeberg LK, Scott JD.
Nat Cell Biol. 2005 Nov; 11(7)1066-73
The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways.
Dodge-Kafka KL, Soughayer J, Pare GC, Carlisle Michel JJ, Langeberg LK, Kapiloff MS, Scott JD.
Nature. 2005 Sep 22; 7058(437)574-8
Snyder EM, Colledge M, Crozier RA, Chen WS, Scott JD, Bear MF.
J Biol Chem. 2005 Apr 29; 17(280)16962-16968
CK2 phosphorylates SSRP1 and inhibits its DNA-binding activity.
Li Y, Keller DM, Scott JD, Lu H.
J Biol Chem. 2005 Mar 25; 12(280)11869-75
AKAP signalling complexes: focal points in space and time.
Wong W, Scott JD.
Nat Rev Mol Cell Biol. 2004 Dec; 12(5)959-70
AKAP-Lbc nucleates a protein kinase D activation scaffold.
Carnegie GK, Smith FD, McConnachie G, Langeberg LK, Scott JD.
Mol Cell. 2004 Sep 24; 6(15)889-99
Scott JD, Englund JA, Myerson D, Geballe AP.
J Clin Virol. 2004 Oct; 2(31)96-9
The role of A-Kinase anchoring proteins in cAMP-mediated signal transduction pathways.
Alto NM, Scott JD.
Cell Biochem Biophys. 2004; 3 Suppl(40)201-8
PKA-phosphorylation of PDE4D3 facilitates recruitment of the mAKAP signalling complex.
Carlisle Michel JJ, Dodge KL, Wong W, Mayer NC, Langeberg LK, Scott JD.
Biochem J. 2004 Aug 1; Pt 3(381)587-92
Orchestration of synaptic plasticity through AKAP signaling complexes.
Bauman AL, Goehring AS, Scott JD.
Neuropharmacology. 2004 Mar; 3(46)299-310
Ubiquitination regulates PSD-95 degradation and AMPA receptor surface expression.
Colledge M, Snyder EM, Crozier RA, Soderling JA, Jin Y, Langeberg LK, Lu H, Bear MF, Scott JD.
Neuron. 2003 Oct 30; 3(40)595-607
Calcineurin anchoring and cell signaling.
Dodge KL, Scott JD.
Biochem Biophys Res Commun. 2003 Nov 28; 4(311)1111-5
A-kinase anchoring proteins and neuronal signaling mechanisms.
Carnegie GK, Scott JD.
Genes Dev. 2003 Jul 1; 13(17)1557-68
Alto NM, Soderling SH, Hoshi N, Langeberg LK, Fayos R, Jennings PA, Scott JD.
Proc Natl Acad Sci U S A. 2003 Apr 15; 8(100)4445-50
Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice.
Soderling SH, Langeberg LK, Soderling JA, Davee SM, Simerly R, Raber J, Scott JD.
Proc Natl Acad Sci U S A. 2003 Feb 18; 4(100)1723-8
Intracellular targeting of protein kinases and phosphatases.
Alto N, Carlisle Michel JJ, Dodge KL, Langeberg LK, Scott JD.
Diabetes. 2002 Dec; (51 Suppl 3)S385-8
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling.
Soderling SH, Binns KL, Wayman GA, Davee SM, Ong SH, Pawson T, Scott JD.
Nat Cell Biol. 2002 Dec; 12(4)970-5
Dell'Acqua ML, Dodge KL, Tavalin SJ, Scott JD.
J Biol Chem. 2002 Dec 13; 50(277)48796-802
Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics.
Alto NM, Soderling J, Scott JD.
J Cell Biol. 2002 Aug 19; 4(158)659-68
Kinase- and phosphatase-anchoring proteins: harnessing the dynamic duo.
Bauman AL, Scott JD.
Nat Cell Biol. 2002 Aug; 8(4)E203-6
Tavalin SJ, Colledge M, Hell JW, Langeberg LK, Huganir RL, Scott JD.
J Neurosci. 2002 Apr 15; 8(22)3044-51
AKAP mediated signal transduction.
Michel JJ, Scott JD.
Annu Rev Pharmacol Toxicol. 2002; (42)235-57
Signaling complexes: junctions on the intracellular information super highway.
Smith FD, Scott JD.
Curr Biol. 2002 Jan 8; 1(12)R32-40
Research Summary
His research program focuses on defining the intracellular communication networks that promote specificity in signal transduction events. Dr. Scott’s lab has identified a family of A-kinase–anchoring proteins (AKAPs) that target the cAMP-dependent protein kinase (PKA) and other signaling enzymes to specific subcellular sites. AKAPs influence the regulation of physiological processes by bringing enzymes close to their appropriate effectors and substrates at precisely the right moment. Dr. Scott and his lab have made significant progress on establishing the AKAP model, the functional consequence