faculty

John Scott

scottjdw@uw.edu
Professor

University of Washington

Pharmacology

Cell Signaling & Cell/Environment Interactions

Signal transduction events that are controlled by anchoring proteins

Faculty Contact Information

Building: Health Sciences Building Room: K-336B Box: 357750 http://faculty.washington.edu/scottjdw/index.html

Research Summary

His research program focuses on defining the intracellular communication networks that promote specificity in signal transduction events. Dr. Scott’s lab has identified a family of A-kinase–anchoring proteins (AKAPs) that target the cAMP-dependent protein kinase (PKA) and other signaling enzymes to specific subcellular sites. AKAPs influence the regulation of physiological processes by bringing enzymes close to their appropriate effectors and substrates at precisely the right moment. Dr. Scott and his lab have made significant progress on establishing the AKAP model, the functional consequence

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Publications

The following publications were retrieved from PubMed:

Neurotensin as a source of cyclic AMP and co-mitogen in fibrolamellar hepatocellular carcinoma.

Riehle KJ, Kenerson HL, Riggle KM, Turnham R, Sullivan K, Bauer R, Scott JD, Yeung RS.

Oncotarget. 2019 Aug 20; 49(10)5092-5102

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma.

Turnham RE, Smith FD, Kenerson HL, Omar MH, Golkowski M, Garcia I, Bauer R, Lau HT, Sullivan KM, Langeberg LK, Ong SE, Riehle KJ, Yeung RS, Scott JD.

Elife. 2019 May 7; (8)

Road map for fibrolamellar carcinoma: progress and goals of a diversified approach.

Kastenhuber ER, Craig J, Ramsey J, Sullivan KM, Sage J, de Oliveira S, Riehle KJ, Scott JD, Gordan JD, Bardeesy N, Abou-Alfa GK.

J Hepatocell Carcinoma. 2019; (6)41-48

Infectious Diseases Society of America Position Statement on Telehealth and Telemedicine as Applied to the Practice of Infectious Diseases.

Young JD, Abdel-Massih R, Herchline T, McCurdy L, Moyer KJ, Scott JD, Wood BR, Siddiqui J.

Clin Infect Dis. 2019 Apr 24; 9(68)1437-1443

MicroRNA-375 Suppresses the Growth and Invasion of Fibrolamellar Carcinoma.

Dinh TA, Jewell ML, Kanke M, Francisco A, Sritharan R, Turnham RE, Lee S, Kastenhuber ER, Wauthier E, Guy CD, Yeung RS, Lowe SW, Reid LM, Scott JD, Diehl AM, Sethupathy P.

Cell Mol Gastroenterol Hepatol. 2019; 4(7)803-817

Accepting Students For:

Rotation, Spring
Rotation, Winter

Lab Information

Location: University of Washington
Building: Health Sciences Builcing
Room: K-316
http://faculty.washington.edu/scottjdw/index.html