faculty

John Scott

scottjdw@uw.edu
Professor

University of Washington

Pharmacology

Cell Signaling & Cell/Environment Interactions

Signal transduction events that are controlled by anchoring proteins

Faculty Contact Information

Building: Health Sciences Building Room: K-336B Box: 357750 http://faculty.washington.edu/scottjdw/index.html

Research Summary

His research program focuses on defining the intracellular communication networks that promote specificity in signal transduction events. Dr. Scott’s lab has identified a family of A-kinase–anchoring proteins (AKAPs) that target the cAMP-dependent protein kinase (PKA) and other signaling enzymes to specific subcellular sites. AKAPs influence the regulation of physiological processes by bringing enzymes close to their appropriate effectors and substrates at precisely the right moment. Dr. Scott and his lab have made significant progress on establishing the AKAP model, the functional consequence

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Publications

The following publications were retrieved from PubMed:

Phosphorylation, compartmentalization, and cardiac function.

Collins KB, Scott JD.

IUBMB Life. 2022 Sep 30;

Assisted Partner Services for People Who Inject Drugs: Index Characteristics Associated With Untreated HIV in Partners.

Tseng AS, Sambai B, Monroe-Wise A, Mbogo LW, Ludwig-Barron NT, Masyuko SJ, Chohan BH, Scott JD, Sinkele W, Herbeck JT, Farquhar C, Guthrie BL.

J Acquir Immune Defic Syndr. 2022 Nov 1; 3(91)269-275

Mislocalization of protein kinase A drives pathology in Cushing's syndrome.

Omar MH, Byrne DP, Jones KN, Lakey TM, Collins KB, Lee KS, Daly LA, Forbush KA, Lau HT, Golkowski M, McKnight GS, Breault DT, Lefrançois-Martinez AM, Martinez A, Eyers CE, Baird GS, Ong SE, Smith FD, Eyers PA, Scott JD.

Cell Rep. 2022 Jul 12; 2(40)111073

Lessons Learned: Building a Comprehensive Telehealth Quality Program.

Kong-Wong C, Weiss MA, Shumway M, Schleyer A, Aas E, Rhodes M, Scott JD.

Am J Med Qual. 2022 Sep-Oct 01; 5(37)456-463

Biochemical Analysis of AKAP-Anchored PKA Signaling Complexes.

Byrne DP, Omar MH, Kennedy EJ, Eyers PA, Scott JD.

Methods Mol Biol. 2022; (2483)297-317

Accepting Students For:

Rotation, Spring
Rotation, Winter

Lab Information

Location: University of Washington
Building: Health Sciences Builcing
Room: K-316
http://faculty.washington.edu/scottjdw/index.html