Jesse Bloom
jbloom@fredhutch.orgFred Hutch,
Computational Biology (Area Director)
Genetics, Genomics & Evolution
Microbiology, Infection & Immunity
The evolution of proteins and viruses
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
Determinants of Zika virus host tropism uncovered by deep mutational scanning.
Setoh YX, Amarilla AA, Peng NYG, Griffiths RE, Carrera J, Freney ME, Nakayama E, Ogawa S, Watterson D, Modhiran N, Nanyonga FE, Torres FJ, Slonchak A, Periasamy P, Prow NA, Tang B, Harrison J, Hobson-Peters J, Cuddihy T, Cooper-White J, Hall RA, Young PR, Mackenzie JM, Wolvetang E, Bloom JD, Suhrbier A, Khromykh AA.
Nature microbiology. 2019; 4(5):876-887.
- PMID:
- 30886357
Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans.
Soh YS, Moncla LH, Eguia R, Bedford T, Bloom JD.
eLife. 2019; 8.
- PMID:
- 31038123
- PMCID:
- PMC6491042
Hom N, Gentles L, Bloom JD, Lee KK.
Journal of virology. 2019;
- PMID:
- 31019050
Reconciling disparate estimates of viral genetic diversity during human influenza infections.
Xue KS, Bloom JD.
Nature genetics. 2019;
- PMID:
- 30804564
Dingens AS, Arenz D, Weight H, Overbaugh J, Bloom JD.
Immunity. 2019; 50(2):520-532.e3. NIHMSID: NIHMS1517127
- PMID:
- 30709739
- PMCID:
- PMC6435357
Comprehensive profiling of translation initiation in influenza virus infected cells.
Machkovech HM, Bloom JD, Subramaniam AR.
PLoS pathogens. 2019; 15(1):e1007518.
- PMID:
- 30673779
- PMCID:
- PMC6361465
Hilton SK, Bloom JD.
Virus evolution. 2018; 4(2):vey033.
- PMID:
- 30425841
- PMCID:
- PMC6220371
Characterization of Influenza B Virus Variants with Reduced Neuraminidase Inhibitor Susceptibility.
Farrukee R, Zarebski AE, McCaw JM, Bloom JD, Reading PC, Hurt AC.
Antimicrobial agents and chemotherapy. 2018; 62(11).
- PMID:
- 30201817
- PMCID:
- PMC6201084
Davis AKF, McCormick K, Gumina ME, Petrie JG, Martin ET, Xue KS, Bloom JD, Monto AS, Bushman FD, Hensley SE.
Journal of virology. 2018; 92(19).
- PMID:
- 30045982
- PMCID:
- PMC6146816
Phillips AM, Ponomarenko AI, Chen K, Ashenberg O, Miao J, McHugh SM, Butty VL, Whittaker CA, Moore CL, Bloom JD, Lin YS, Shoulders MD.
PLoS biology. 2018; 16(9):e3000008.
- PMID:
- 30222731
- PMCID:
- PMC6160216
Research Summary
We use a combination of experimental and computational approaches to study molecular evolution. We especially focus on viruses such as influenza.