faculty

Jesse Bloom

jbloom@fredhutch.org

Fred Hutch, 

Computational Biology (Area Director)

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

The evolution of proteins and viruses

Faculty Contact Information

Building: Weintraub Room: B3-160 Box: A3-020 http://research.fhcrc.org/bloom/en.html

Lab Information

Location: Fred Hutch Building: Weintraub building Room: B3-123 Phone: 206-667-3603 http://research.fhcrc.org/bloom/en.html

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Deep Mutational Scan of the Highly Conserved Influenza A Virus M1 Matrix Protein Reveals Substantial Intrinsic Mutational Tolerance.

Hom N, Gentles L, Bloom JD, Lee KK.

Journal of virology. 2019; 93(13).

PubMed [journal]
PMID:
31019050
PMCID:
PMC6580950

Determinants of Zika virus host tropism uncovered by deep mutational scanning.

Setoh YX, Amarilla AA, Peng NYG, Griffiths RE, Carrera J, Freney ME, Nakayama E, Ogawa S, Watterson D, Modhiran N, Nanyonga FE, Torres FJ, Slonchak A, Periasamy P, Prow NA, Tang B, Harrison J, Hobson-Peters J, Cuddihy T, Cooper-White J, Hall RA, Young PR, Mackenzie JM, Wolvetang E, Bloom JD, Suhrbier A, Khromykh AA.

Nature microbiology. 2019; 4(5):876-887.

PubMed [journal]
PMID:
30886357

Comprehensive mapping of adaptation of the avian influenza polymerase protein PB2 to humans.

Soh YS, Moncla LH, Eguia R, Bedford T, Bloom JD.

eLife. 2019; 8.

PubMed [journal]
PMID:
31038123
PMCID:
PMC6491042

Reconciling disparate estimates of viral genetic diversity during human influenza infections.

Xue KS, Bloom JD.

Nature genetics. 2019;

PubMed [journal]
PMID:
30804564

An Antigenic Atlas of HIV-1 Escape from Broadly Neutralizing Antibodies Distinguishes Functional and Structural Epitopes.

Dingens AS, Arenz D, Weight H, Overbaugh J, Bloom JD.

Immunity. 2019; 50(2):520-532.e3. NIHMSID: NIHMS1517127

PubMed [journal]
PMID:
30709739
PMCID:
PMC6435357

Research Summary

We use a combination of experimental and computational approaches to study molecular evolution. We especially focus on viruses such as influenza.