faculty

Jesse Bloom

jbloom@fredhutch.org

Fred Hutch, 

Computational Biology (Area Director)

Genetics, Genomics & Evolution

Microbiology, Infection & Immunity

The evolution of proteins and viruses

Faculty Contact Information

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Modeling site-specific amino-acid preferences deepens phylogenetic estimates of viral sequence divergence.

Hilton SK, Bloom JD.

Virus evolution. 2018; 4(2):vey033.

PubMed [journal]
PMID:
30425841
PMCID:
PMC6220371

Characterization of Influenza B Virus Variants with Reduced Neuraminidase Inhibitor Susceptibility.

Farrukee R, Zarebski AE, McCaw JM, Bloom JD, Reading PC, Hurt AC.

Antimicrobial agents and chemotherapy. 2018; 62(11).

PubMed [journal]
PMID:
30201817
PMCID:
PMC6201084

Sera from Individuals with Narrowly Focused Influenza Virus Antibodies Rapidly Select Viral Escape Mutations In Ovo.

Davis AKF, McCormick K, Gumina ME, Petrie JG, Martin ET, Xue KS, Bloom JD, Monto AS, Bushman FD, Hensley SE.

Journal of virology. 2018; 92(19).

PubMed [journal]
PMID:
30045982
PMCID:
PMC6146816

Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones.

Phillips AM, Ponomarenko AI, Chen K, Ashenberg O, Miao J, McHugh SM, Butty VL, Whittaker CA, Moore CL, Bloom JD, Lin YS, Shoulders MD.

PLoS biology. 2018; 16(9):e3000008.

PubMed [journal]
PMID:
30222731
PMCID:
PMC6160216

Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin.

Phillips AM, Doud MB, Gonzalez LO, Butty VL, Lin YS, Bloom JD, Shoulders MD.

eLife. 2018; 7.

PubMed [journal]
PMID:
30188321
PMCID:
PMC6172027

Research Summary

We use a combination of experimental and computational approaches to study molecular evolution. We especially focus on viruses such as influenza.