Michael Lagunoff


University of Washington, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity (Area Director)

Viral oncology

Faculty Contact Information

Building: SLU Room: F-573 Box: 358070 Phone: 206-616-4285 http://microbiology.washington.edu/users/michael-lagunoff

Lab Information

Location: University of Washington, South Lake Union Building: SLU F building Room: F-5 Box: 358070 Phone: 221-569 http://microbiology.washington.edu/users/michael-lagunoff

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter


The following publications were retrieved from PubMed:

Chewing the Fat: The Conserved Ability of DNA Viruses to Hijack Cellular Lipid Metabolism.

Lange PT, Lagunoff M, Tarakanova VL.

Viruses. 2019 Jan 29; 2(11)

Quantitative Analysis of the KSHV Transcriptome Following Primary Infection of Blood and Lymphatic Endothelial Cells.

Bruce AG, Barcy S, DiMaio T, Gan E, Garrigues HJ, Lagunoff M, Rose TM.

Pathogens. 2017 Mar 19; 1(6)

Glycolysis, Glutaminolysis, and Fatty Acid Synthesis Are Required for Distinct Stages of Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication.

Sanchez EL, Pulliam TH, Dimaio TA, Thalhofer AB, Delgado T, Lagunoff M.

J Virol. 2017 May 15; 10(91)

Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism.

Sychev ZE, Hu A, DiMaio TA, Gitter A, Camp ND, Noble WS, Wolf-Yadlin A, Lagunoff M.

PLoS Pathog. 2017 Mar; 3(13)e1006256

Research Summary

The Lagunoff lab is interested in how viruses cause cancer. Their focus is on Kaposi’s Sarcoma herpesvirus (KSHV), the etiologic agent of Kaposi’s Sarcoma, the most common tumor of AIDS patients and among the most common tumors overall in Sub-Saharan Africa. The lab is interested in how KSHV alters host endothelial cell metabolism, oncogenic signal transduction pathways and the innate immune response to lead to tumor formation.