faculty

Trisha Davis

tdavis@uw.edu

University of Washington, 

Cancer Biology

Gene Expression, Cell Cycle & Chromosome Biology

Genetics, Genomics & Evolution

Biochemical and biophysical analysis of mitosis

Faculty Contact Information

Building: Health Sciences Building Room: J459 Box: 357350 Phone: 206-543-5345 http://depts.washington.edu/biowww/pages/faculty-Davis.shtml

Lab Information

Location: University of Washington Building: Health Sciences Building Room: J457 Box: 357350 Phone: 206-543-5354 http://depts.washington.edu/davislab/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Winter
Permanent

Publications

Proxl (Protein Cross-Linking Database): A Public Server, QC Tools, and Other Major Updates.

Riffle M, Jaschob D, Zelter A, Davis TN.

Journal of proteome research. 2019; 18(2):759-764. NIHMSID: NIHMS1016754

PubMed [journal]
PMID:
30525651
PMCID:
PMC6417915

A Bifunctional Role for the UHRF1 UBL Domain in the Control of Hemi-methylated DNA-Dependent Histone Ubiquitylation.

DaRosa PA, Harrison JS, Zelter A, Davis TN, Brzovic P, Kuhlman B, Klevit RE.

Molecular cell. 2018; 72(4):753-765.e6. NIHMSID: NIHMS1507957

PubMed [journal]
PMID:
30392931
PMCID:
PMC6239910

Novel phosphorylation states of the yeast spindle pole body.

Fong KK, Zelter A, Graczyk B, Hoyt JM, Riffle M, Johnson R, MacCoss MJ, Davis TN.

Biology open. 2018; 7(10).

PubMed [journal]
PMID:
29903865
PMCID:
PMC6215409

Human Ska complex and Ndc80 complex interact to form a load-bearing assembly that strengthens kinetochore-microtubule attachments.

Helgeson LA, Zelter A, Riffle M, MacCoss MJ, Asbury CL, Davis TN.

Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(11):2740-2745.

PubMed [journal]
PMID:
29487209
PMCID:
PMC5856539

Identification of Wiskott-Aldrich syndrome protein (WASP) binding sites on the branched actin filament nucleator Arp2/3 complex.

Luan Q, Zelter A, MacCoss MJ, Davis TN, Nolen BJ.

Proceedings of the National Academy of Sciences of the United States of America. 2018; 115(7):E1409-E1418.

PubMed [journal]
PMID:
29386393
PMCID:
PMC5816175

Research Summary

How does the cell ensure transmission of an exact complement of chromosomes each cell division? How does this process go awry in cancer cells? These are questions of interest to our lab. We use a variety of techniques from single-molecule biophysical approaches to biochemistry, genetics and microscopy to explore the regulation and action of the cell cycle machinery that ensures fidelity of chromosome segregation.