faculty

Karin Bornfeldt

bornf@uw.edu
Professor

University of Washington

Pathology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity

Mechanisms of cardiovascular disease associated with diabetes

Faculty Contact Information

Research Summary

People with type 1 or type 2 diabetes have a greater risk of developing cardiovascular disease (myocardial infarction, stroke). The cardiovascular disease is caused primarily by atherosclerosis. Our research focuses on understanding the mechanisms of diabetes-accelerated atherosclerosis so that cardiovascular complications can be treated or prevented. We study mouse models, isolated cells and human samples.

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Publications

The following publications were retrieved from PubMed:

Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes.

Kanter JE, Shao B, Kramer F, Barnhart S, Shimizu-Albergine M, Vaisar T, Graham MJ, Crooke RM, Manuel CR, Haeusler RA, Mar D, Bomsztyk K, Hokanson JE, Kinney GL, Snell-Bergeon JK, Heinecke JW, Bornfeldt KE.

J Clin Invest. 2019 Jul 11; (130)

Albuminuria, the High-Density Lipoprotein Proteome, and Coronary Artery Calcification in Type 1 Diabetes Mellitus.

Shao B, Zelnick LR, Wimberger J, Himmelfarb J, Brunzell J, Davidson WS, Snell-Bergeon JK, Bornfeldt KE, de Boer IH, Heinecke JW.

Arterioscler Thromb Vasc Biol. 2019 Jul; 7(39)1483-1491

Apolipoprotein A1 Forms 5/5 and 5/4 Antiparallel Dimers in Human High-density Lipoprotein.

He Y, Song HD, Anantharamaiah GM, Palgunachari MN, Bornfeldt KE, Segrest JP, Heinecke JW.

Mol Cell Proteomics. 2019 May; 5(18)854-864

Highlighting Residual Atherosclerotic Cardiovascular Disease Risk.

Matsuura Y, Kanter JE, Bornfeldt KE.

Arterioscler Thromb Vasc Biol. 2019 Jan; 1(39)e1-e9

Accepting Students For:

Rotation, Autumn
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Permanent

Lab Information

Location: University of Washington
Building: SLU F
Room: F631
Box: 358062
Phone: 206-616-3551
http://depts.washington.edu/doce/our-research/research-programs/the-bornfeldt-laboratory/