faculty

Karin Bornfeldt

bornf@uw.edu
Professor

University of Washington

Pathology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity

Mechanisms of cardiovascular disease associated with diabetes

Faculty Contact Information

Research Summary

People with type 1 or type 2 diabetes have a greater risk of developing cardiovascular disease (myocardial infarction, stroke). The cardiovascular disease is caused primarily by atherosclerosis. Our research focuses on understanding the mechanisms of diabetes-accelerated atherosclerosis so that cardiovascular complications can be treated or prevented. We study mouse models, isolated cells and human samples.

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Publications

The following publications were retrieved from PubMed:

A role of heme degradation pathway in shaping prostate inflammatory responses and lipid metabolism.

Lilljebjörn LV, Csizmadia E, Hedblom A, Canesin G, Kalbasi A, Li M, Kramer F, Bornfeldt KE, Wegiel B.

Am J Pathol. 2020 Feb 5;

Hematopoietic Cell-Expressed Endothelial Nitric Oxide Protects the Liver From Insulin Resistance.

Dick BP, McMahan R, Knowles T, Becker L, Gharib SA, Vaisar T, Wietecha T, O'Brien KD, Bornfeldt KE, Chait A, Kim F.

Arterioscler Thromb Vasc Biol. 2020 Jan 30; ATVBAHA119313648

Correction: Cardiomyocyte-specific disruption of Cathepsin K protects against doxorubicin-induced cardiotoxicity.

Guo R, Hua Y, Ren J, Bornfeldt KE, Nair S.

Cell Death Dis. 2019 Dec 5; 12(10)933

TNF-α induces acyl-CoA synthetase 3 to promote lipid droplet formation in human endothelial cells.

Jung HS, Shimizu-Albergine M, Shen X, Kramer F, Shao D, Vivekanandan-Giri A, Pennathur S, Tian R, Kanter JE, Bornfeldt KE.

J Lipid Res. 2020 Jan; 1(61)33-44

Accepting Students For:

Rotation, Autumn
Rotation, Spring
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Rotation, Winter
Permanent

Lab Information

Location: University of Washington
Building: SLU F
Room: F631
Box: 358062
Phone: 206-616-3551
http://depts.washington.edu/doce/our-research/research-programs/the-bornfeldt-laboratory/