Microbiology, Infection & Immunity (Area Director)
Innate immunity in infection and cancer
Faculty Contact Information
We are studying innate immunity; i.e., the very first steps in the development of immune responses. Our ongoing studies are addressing:
1) How does the immune system differentiate normal cell death from stress-induced death?
2) In co-infection models, how does a first infection affect the response to a second pathogen?
3) In cancer, how do macrophages infiltrate the tumor and shape antitumoral immunity?
To address these questions, we are developing specific genetically-modified mice, including “humanized mouse” models that allow us to translate our findings to pre-clinical conditions.
I believe that each of us has unique talents, and that we can best express them in a flexible environment. In the lab, we work as a team in which each of us benefits from the contributions of all other members. The diversity in our respective trainings, in our cultural backgrounds and in our life experiences broadens each of our perspectives and helps us approach science with an open mind. As a mentor, my role is to foster this open, respectful and collaborative environment, and guide each lab member toward their most ambitious scientific and career goals.
2021: Bias Mitigation Education: Grounding & Commitment (Fred Hutch’s Office of Diversity, Equity & Inclusion)
2021: Towards Effective Mentorship Practices (UW’s Office of Equity & Justice in Graduate Programs)
The following publications were retrieved from PubMed:
Martinov T, McKenna KM, Tan WH, Collins EJ, Kehret AR, Linton JD, Olsen TM, Shobaki N, Rongvaux A.
Front Immunol. 2021; (12)643852
Biernacki MA, Foster KA, Woodward KB, Coon ME, Cummings C, Cunningham TM, Dossa RG, Brault M, Stokke J, Olsen TM, Gardner K, Estey E, Meshinchi S, Rongvaux A, Bleakley M.
J Clin Invest. 2020 Oct 1; 10(130)5127-5141
Sippel TR, Radtke S, Olsen TM, Kiem HP, Rongvaux A.
Blood Adv. 2019 Feb 12; 3(3)268-274
Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S.
Nat Commun. 2019 Jan 21; 1(10)366
Radtke S, Chan YY, Sippel TR, Kiem HP, Rongvaux A.
Exp Hematol. 2019 Feb; (70)31-41.e1
Mitochondrion. 2018 Jul; (41)14-20
Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks SG, Strowig T, Kumar P, Siliciano JD, Salzberg SL, Flavell RA, Shan L, Siliciano RF.
Nature. 2015 Jan 15; 7534(517)381-5
Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA.
Cell. 2014 Dec 18; 7(159)1563-77
Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.
Nat Biotechnol. 2014 Apr; 4(32)364-72
Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.
Annu Rev Immunol. 2013; (31)635-674
Strowig T, Rongvaux A, Rathinam C, Takizawa H, Borsotti C, Philbrick W, Eynon EE, Manz MG, Flavell RA.
Proc Natl Acad Sci U S A. 2011 Aug 9; 32(108)13218-23
Rongvaux A, Willinger T, Takizawa H, Rathinam C, Auerbach W, Murphy AJ, Valenzuela DM, Yancopoulos GD, Eynon EE, Stevens S, Manz MG, Flavell RA.
Proc Natl Acad Sci U S A. 2011 Feb 8; 6(108)2378-83
Rongvaux A, Galli M, Denanglaire S, Van Gool F, Drèze PL, Szpirer C, Bureau F, Andris F, Leo O.
J Immunol. 2008 Oct 1; 7(181)4685-95
Rongvaux A, Andris F, Van Gool F, Leo O.
Bioessays. 2003 Jul; 7(25)683-90
Rongvaux A, Shea RJ, Mulks MH, Gigot D, Urbain J, Leo O, Andris F.
Eur J Immunol. 2002 Nov; 11(32)3225-34
PubMed Collection Link
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Building: Thomas Building
Box: Mail stop D3-100