Microbiology, Infection & Immunity
The innate immune response to abnormal cells
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We are studying the very first steps in the development of an immune response after exposure to a pathogen or formation of a tumor. Our work focuses on understanding how the immune system detects and responds to the presence of abnormal cells. In particular, we are studying:
1) How dying cells interact with the immune system.
2) How macrophages contribute to tumor development.
To address these questions, we are developing specific models of genetically-modified mice, including “humanized mouse” models that allow us to translate our findings to pre-clinical conditions.