faculty

Anthony Rongvaux

rongvaux@fredhutch.org
Assistant Professor

Fred Hutch

Clinical Research

Cancer Biology

Microbiology, Infection & Immunity

Innate immunity in infection and cancer

Faculty Contact Information

Building: Thomas Building Room: D3-110 Box: D3-100 Phone: 206-667-7753 http://research.fhcrc.org/rongvaux/en.html

Research Summary

We are studying innate immunity; i.e., the very first steps in the development of immune responses. Our ongoing studies are addressing:
1) How does the immune system differentiate normal cell death from stress-induced death?
2) In co-infection models, how does a first infection affect the response to a second pathogen?
3) In cancer, how do macrophages infiltrate the tumor and shape antitumoral immunity?
To address these questions, we are developing specific genetically-modified mice, including “humanized mouse” models that allow us to translate our findings to pre-clinical conditions.

DEI Statement

I believe that each of us has unique talents, and that we can best express them in a flexible environment. In the lab, we work as a team in which each of us benefits from the contributions of all other members. The diversity in our respective trainings, in our cultural backgrounds and in our life experiences broadens each of our perspectives and helps us approach science with an open mind. As a mentor, my role is to foster this open, respectful and collaborative environment, and guide each lab member toward their most ambitious scientific and career goals.

Training Summary

2021: Bias Mitigation Education: Grounding & Commitment (Fred Hutch’s Office of Diversity, Equity & Inclusion)

2021: Towards Effective Mentorship Practices (UW’s Office of Equity & Justice in Graduate Programs)

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Publications

The following publications were retrieved from PubMed:

Building the Next Generation of Humanized Hemato-Lymphoid System Mice.

Martinov T, McKenna KM, Tan WH, Collins EJ, Kehret AR, Linton JD, Olsen TM, Shobaki N, Rongvaux A.

Front Immunol. 2021; (12)643852

CBFB-MYH11 fusion neoantigen enables T cell recognition and killing of acute myeloid leukemia.

Biernacki MA, Foster KA, Woodward KB, Coon ME, Cummings C, Cunningham TM, Dossa RG, Brault M, Stokke J, Olsen TM, Gardner K, Estey E, Meshinchi S, Rongvaux A, Bleakley M.

J Clin Invest. 2020 Oct 1; 10(130)5127-5141

Human hematopoietic stem cell maintenance and myeloid cell development in next-generation humanized mouse models.

Sippel TR, Radtke S, Olsen TM, Kiem HP, Rongvaux A.

Blood Adv. 2019 Feb 12; 3(3)268-274

A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.

Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S.

Nat Commun. 2019 Jan 21; 1(10)366

MISTRG mice support engraftment and assessment of nonhuman primate hematopoietic stem and progenitor cells.

Radtke S, Chan YY, Sippel TR, Kiem HP, Rongvaux A.

Exp Hematol. 2019 Feb; (70)31-41.e1



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Location: Fred Hutch
Building: Thomas Building
Room: D3-263
Box: Mail stop D3-100
http://research.fhcrc.org/rongvaux/en.html