faculty

Anthony Rongvaux

rongvaux@fredhutch.org
Assistant Member

Fred Hutch

Clinical Research

Cancer Biology

Microbiology, Infection & Immunity

The innate immune response to abnormal cells

Faculty Contact Information

Building: Thomas Building Room: D3-197 Box: D3-100 Phone: 206-667-7753 http://research.fhcrc.org/rongvaux/en.html

Research Summary

We are studying the very first steps in the development of an immune response after exposure to a pathogen or formation of a tumor. Our work focuses on understanding how the immune system detects and responds to the presence of abnormal cells. In particular, we are studying:

1) How dying cells interact with the immune system.

2) How macrophages contribute to tumor development.

To address these questions, we are developing specific models of genetically-modified mice, including “humanized mouse” models that allow us to translate our findings to pre-clinical conditions.

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Publications

The following publications were retrieved from PubMed:

Peripheral blood CD34<sup>+</sup> cells efficiently engraft human cytokine knock-in mice.

Saito Y, Ellegast JM, Rafiei A, Song Y, Kull D, Heikenwalder M, Rongvaux A, Halene S, Flavell RA, Manz MG.

Blood. 2016 Oct 6; 14(128)1829-1833

Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System.

Henao-Mejia J, Williams A, Rongvaux A, Stein J, Hughes C, Flavell RA.

Cold Spring Harb Protoc. 2016 Feb 1; 2(2016)pdb.prot090704

Broad CTL response is required to clear latent HIV-1 due to dominance of escape mutations.

Deng K, Pertea M, Rongvaux A, Wang L, Durand CM, Ghiaur G, Lai J, McHugh HL, Hao H, Zhang H, Margolick JB, Gurer C, Murphy AJ, Valenzuela DM, Yancopoulos GD, Deeks SG, Strowig T, Kumar P, Siliciano JD, Salzberg SL, Flavell RA, Shan L, Siliciano RF.

Nature. 2015 Jan 15; 7534(517)381-5

Apoptotic caspases prevent the induction of type I interferons by mitochondrial DNA.

Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA.

Cell. 2014 Dec 18; 7(159)1563-77

Development and function of human innate immune cells in a humanized mouse model.

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Nat Biotechnol. 2014 Apr; 4(32)364-72

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Lab Information

Location: Fred Hutch
Building: Thomas Building
Room: D3-263
Box: Mail stop D3-100
Phone: 206-667-7753
Alt Phone: 2066677753
http://research.fhcrc.org/rongvaux/en.html