faculty

Zipora Yablonka-Reuveni

reuveni@u.washington.edu
Professor

University of Washington

Biological Structure

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Origin and regulation of myogenic stem cells in skeletal muscle

Faculty Contact Information

Building: Health Sciences Building Room: G-503 Box: 357420 Phone: 206-685-2708

Research Summary

Our research focuses on the origin and regulation of myogenic stem cells in skeletal muscle. Our long-term goal is to identify means to ameliorate age-related muscle deterioration (sarcopenia) and muscle wasting disorders due to muscular dystrophy. Sarcopenia is characterized by a decline in mass, strength, and endurance of skeletal muscles, and by fat accumulation between and within myofibers. Subtle muscle injuries that occur during routine muscle activity raise a continuous demand for functional myofiber repair throughout life. However, myogenic stem cell performance declines in old age.

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Publications

The following publications were retrieved from PubMed:

Expression profile and overexpression outcome indicate a role for βKlotho in skeletal muscle fibro/adipogenesis.

Phelps M, Stuelsatz P, Yablonka-Reuveni Z.

FEBS J. 2016 May; 9(283)1653-68

Isolation and Characterization of Satellite Cells from Rat Head Branchiomeric Muscles.

Carvajal Monroy PL, Yablonka-Reuveni Z, Grefte S, Kuijpers-Jagtman AM, Wagener FA, Von den Hoff JW.

J Vis Exp. 2015 Jul 20; 101e52802

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