University of Washington,
Biophysical and Structural Biology
Cell Signaling & Cell/Environment Interactions
Structural biology of protein ubiquitination and transmembrane signaling
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Research in our laboratory is aimed at dissecting the molecular and structural mechanisms by which protein-protein interactions control eukaryotic biology and human diseases. We emphasize on challenging yet fundamental questions that will have cross-disciplinary significances and impacts. We have a long-standing interest in how enzymes regulate protein ubiquitination, their roles in signaling, and their therapeutic potentials. We have also developed a second research program focusing on membrane protein structure biology.