faculty

Ning Zheng

nzheng@uw.edu
Professor

University of Washington

Pharmacology

Biophysical and Structural Biology

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Protein Ubiquitination and Drug Discovery

Faculty Contact Information

Building: Health Sciences Buildings Room: D-409 Box: 357280 Phone: 206-616-3990 http://depts.washington.edu/zhenglab/

Research Summary

Research in our laboratory is aimed at dissecting the molecular and structural mechanisms by which protein-protein interactions control eukaryotic biology and human diseases. We emphasize on challenging yet fundamental questions that will have cross-disciplinary significances and impacts. We have a long-standing interest in how protein ubiquitination regulate various cellular pathways and the discovery of novel therapeutic compounds acting through targeted protein degradation.

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Publications

The following publications were retrieved from PubMed:

Structural basis of salicylic acid perception by Arabidopsis NPR proteins.

Wang W, Withers J, Li H, Zwack PJ, Rusnac DV, Shi H, Liu L, Yan S, Hinds TR, Guttman M, Dong X, Zheng N.

Nature. 2020 Oct; 7828(586)311-316

FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.

Wang H, Shi H, Rajan M, Canarie ER, Hong S, Simoneschi D, Pagano M, Bush MF, Stoll S, Leibold EA, Zheng N.

Mol Cell. 2020 Apr 2; 1(78)31-41.e5

Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing.

Fribourgh JL, Srivastava A, Sandate CR, Michael AK, Hsu PL, Rakers C, Nguyen LT, Torgrimson MR, Parico GCG, Tripathi S, Zheng N, Lander GC, Hirota T, Tama F, Partch CL.

Elife. 2020 Feb 26; (9)

Structure of an Inner Membrane Protein Required for PhoPQ-Regulated Increases in Outer Membrane Cardiolipin.

Fan J, Petersen EM, Hinds TR, Zheng N, Miller SI.

mBio. 2020 Feb 11; 1(11)

Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.

Lin H, Zhang X, Liu L, Fu Q, Zang C, Ding Y, Su Y, Xu Z, He S, Yang X, Wei X, Mao H, Cui Y, Wei Y, Zhou C, Du L, Huang N, Zheng N, Wang T, Rao F.

Proc Natl Acad Sci U S A. 2020 Feb 25; 8(117)4117-4124

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Lab Information

Location: University of Washington
Building: Health Sciences Building
Room: D-429
Box: 357280
Phone: 206-616-3887
http://depts.washington.edu/zhenglab/