University of Washington,
Cell Signaling & Cell/Environment Interactions
Genetics, Genomics & Evolution
Microbiology, Infection & Immunity
Parasitology and Evolution of the Cytoskeleton
Faculty Contact Information
Giardia lamblia, is an extracellular parasite that uses its cytoskeleton to attach to the host intestine. In addition to being a major parasite, it belongs to a deep branching group of eukaryotes known as the Excavates. Intriguingly, Giardia lacks all canonical actin binding proteins. Still, its actin cytoskeleton performs essential cellular roles and has complex organization that is regulated by a minimalistic Rho GTPase signaling system. We aim to uncover the molecules and mechanisms of cytoskeletal regulation for therapeutic development and to gain evolutionary insight.
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