faculty

Zhengui Xia

zxia@uw.edu
Professor

University of Washington

Toxicology Program

Cell Signaling & Cell/Environment Interactions

Developmental Biology, Stem Cells & Aging

Neuroscience

gene and environment interaction on adult neurogenesis and neurodegeneration

Faculty Contact Information

Building: HSB Room: F561C Box: 357234 Phone: 206-616-9433

Research Summary

It has been hypothesized that exposure to environmental factors may increase Alzheimer’s disease (AD) risk. However, there is a paucity of evidence supporting this hypothesis. The hippocampus is critical for cognition and especially vulnerable to damage at early stages of AD. We are using transgenic mouse models to test the hypotheses that a gene-environment interaction between environmental exposure and the presence of gene(s) with increased risk for AD impairs adult hippocampal neurogenesis and contributes to neuronal loss and cognitive decline in the initiation and progression of AD.

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Publications

The following publications were retrieved from PubMed:

Cadmium Exposure Impairs Adult Hippocampal Neurogenesis.

Wang H, Abel GM, Storm DR, Xia Z.

Toxicol Sci. 2019 Jul 4;

Dynamics of a hippocampal neuronal ensemble encoding trace fear memory revealed by in vivo Ca2+ imaging.

Zhang L, Chen X, Sindreu C, Lu S, Storm DR, Zweifel LS, Xia Z.

PLoS One. 2019; 7(14)e0219152

Myeloid ERK5 deficiency suppresses tumor growth by blocking protumor macrophage polarization via STAT3 inhibition.

Giurisato E, Xu Q, Lonardi S, Telfer B, Russo I, Pearson A, Finegan KG, Wang W, Wang J, Gray NS, Vermi W, Xia Z, Tournier C.

Proc Natl Acad Sci U S A. 2018 Mar 20; 12(115)E2801-E2810

Cadmium Exposure Impairs Cognition and Olfactory Memory in Male C57BL/6 Mice.

Wang H, Zhang L, Abel GM, Storm DR, Xia Z.

Toxicol Sci. 2018 Jan 1; 1(161)87-102

Lab Information

Location: UW
Building: HSB
Room: F553
Box: 357234
Phone: 206-616-3634
Alt Phone: 2065436097
http://depts.washington.edu/xialab