University of Washington,
Cell Signaling & Cell/Environment Interactions
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution (Area Director)
Development and evolution in Drosophila oogenesis
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We use Drosophila to ask developmental and evolutionary questions concerning patterning and shape. How do individual cells within a sheet become different from each other? How do cells work together to create an organ? How are these processes modulated to create new forms? Our genetic tools let us manipulate gene function in single cells. Our genomic tools let us compare species over a range of evolutionary time. Our live imaging system lets us explore processes in real time. How pattern and shape create form is important because imperfections in these processes cause birth defects.