faculty

Brian Iritani

biritani@uw.edu

Professor

University of Washington

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity

Lymphocyte development and transformation

Faculty Contact Information

Building: Health Sciences Building Room: I-438 Box: 357340 Phone: 206-221-3932 Alt Phone: 206-375-3402 https://www.washington.edu/compmed/facultystaff/faculty-directory/brian-m-iritani/

Research Summary

The Iritani lab is interested in understanding the molecular mechanisms that control the development and functions of lymphocytes, and how when dysregulated, these signaling pathways can result in immunodeficiency diseases, autoimmunity, and/or cancer. Utilizing a chemical mutagenesis screen in mice, we identified several novel signaling molecules that are essential for lymphocyte development by regulating cell metabolism and the actin cytoskeleton respectively. We utilize transcriptomics, proteomics, and metabolomics in murine models for understanding how these molecules function.

DEI Statement

I am a member of the MCB Diversity Committee, UW School of Medicine (SOM) DEI task force committee, SOM Minority Recruitment Committee, SOM Basic Sciences DEI Recruitment Committee, and I Chair the UW Department of Comparative Medicine DEI Committee (https://www.washington.edu/compmed/diversity/). I believe a diverse and inclusive faculty, staff, and student body is essential for providing new perspectives, better solutions in the workplace, and making creative research discoveries. As such, I strive to increase DEI in the SOM, MCB, DCM, and my research laboratory

Training Summary

Over the past 10 years I have taken numerous (i.e. 30+) UW, SOM, and national workshops on how to increase DEI in the workplace and how to improve mentoring of diverse students. Most recently this has included the 2020 University of Minnesota online training on Optimizing the Practice of Mentoring, and the 2020 University of Wisconsin CIMER training on Culturally Aware Mentoring.

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Publications

The following publications were retrieved from PubMed:

The actin-regulatory protein Hem-1 is essential for alveolar macrophage development.

Suwankitwat N, Libby S, Liggitt HD, Avalos A, Ruddell A, Rosch JW, Park H, Iritani BM.

J Exp Med. 2021 Apr 5; 4(218)

Metabolism meets immunodeficiency disease.

Iritani BM

Blood. 2021 Jan 28; 4(137)436-437

Folliculin Interacting Protein 1 Maintains Metabolic Homeostasis during B Cell Development by Modulating AMPK, mTORC1, and TFE3.

Ramírez JA, Iwata T, Park H, Tsang M, Kang J, Cui K, Kwong W, James RG, Baba M, Schmidt LS, Iritani BM.

J Immunol. 2019 Dec 1; 11(203)2899-2908

Loss of Fnip1 alters kidney developmental transcriptional program and synergizes with TSC1 loss to promote mTORC1 activation and renal cyst formation.

Centini R, Tsang M, Iwata T, Park H, Delrow J, Margineantu D, Iritani BM, Gu H, Liggitt HD, Kang J, Kang L, Hockenbery DM, Raftery D, Iritani BM.

PLoS One. 2018; 6(13)e0197973

Murine norovirus inhibits B cell development in the bone marrow of STAT1-deficient mice.

Hsu CC, Meeker SM, Escobar S, Brabb TL, Paik J, Park H, Iritani BM, Maggio-Price L.

Virology. 2018 Feb; (515)123-133

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Lab Information

Location: University of Washington
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Room: I-604J
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