faculty

Karol Bomsztyk

karolb@u.washington.edu
Professor

University of Washington

Pharmacology

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Gene Expression, Cell Cycle & Chromosome Biology

Epigenetic alteration in disease

Faculty Contact Information

Building: UW Medicine SLU Room: Brotman Room 243 Box: 358050 Phone: 206-616-7949 Alt Phone: 206-543-1014

Research Summary

Detrimental epigenetic processes are emerging as major pathophysiologic culprits of disease including cancer, inflammation, infection and organ injury. These processes involve signaling, transcription and epigenetic factors that regulate gene transcription in the chromatin environment, or the epigenome. To better define epigenetic processes in health and disease, our laboratory has been developing high throughput and sensitivity epigenetic platforms and computational tools and have applied them to study acute organ injury, cancer and inflammation.

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Publications

The following publications were retrieved from PubMed:

Genome-bound enzymes as epigenetic drug targets in cancer.

Bomsztyk K, Wang Y.

Epigenomics. 2019 Sep 19;

Increased apolipoprotein C3 drives cardiovascular risk in type 1 diabetes.

Kanter JE, Shao B, Kramer F, Barnhart S, Shimizu-Albergine M, Vaisar T, Graham MJ, Crooke RM, Manuel CR, Haeusler RA, Mar D, Bomsztyk K, Hokanson JE, Kinney GL, Snell-Bergeon JK, Heinecke JW, Bornfeldt KE.

J Clin Invest. 2019 Jul 11; (130)

PIXUL-ChIP: integrated high-throughput sample preparation and analytical platform for epigenetic studies.

Bomsztyk K, Mar D, Wang Y, Denisenko O, Ware C, Frazar CD, Blattler A, Maxwell AD, MacConaghy BE, Matula TJ.

Nucleic Acids Res. 2019 Jul 9; 12(47)e69

Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury.

Sharifian R, Okamura DM, Denisenko O, Zager RA, Johnson A, Gharib SA, Bomsztyk K.

Sci Rep. 2018 Dec 14; 1(8)17870

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Lab Information

Location: University of Washington
Building: UW Medicine SLU
Room: Brotman Room 243
Box: Box 358050
Phone: 206-543-1014
Alt Phone: 206-616-4949