Karol Bomsztyk


University of Washington, 

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Gene Expression, Cell Cycle & Chromosome Biology

Epigenetic alteration in disease

Faculty Contact Information

Building: UW Medicine SLU Room: Brotman Room 243 Box: 358050 Phone: 206-616-7949 Alt Phone: 206-543-1014

Lab Information

Location: University of Washington Building: UW Medicine SLU Room: Brotman Room 243 Box: Box 358050 Phone: 206-543-1014 Alt Phone: 206-616-4949

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter


The following publications were retrieved from PubMed:

PIXUL-ChIP: integrated high-throughput sample preparation and analytical platform for epigenetic studies.

Bomsztyk K, Mar D, Wang Y, Denisenko O, Ware C, Frazar CD, Blattler A, Maxwell AD, MacConaghy BE, Matula TJ.

Nucleic Acids Res. 2019 Mar 30;

Distinct patterns of transcriptional and epigenetic alterations characterize acute and chronic kidney injury.

Sharifian R, Okamura DM, Denisenko O, Zager RA, Johnson A, Gharib SA, Bomsztyk K.

Sci Rep. 2018 Dec 14; 1(8)17870

Chromatin changes trigger laminin genes dysregulation in aging kidneys.

Denisenko O, Mar D, Trawczynski M, Bomsztyk K.

Aging (Albany NY). 2018 May 29; 5(10)1133-1145

DNA methylation yields epigenetic clues into the diabetic nephropathy of Pima Indians.

Bomsztyk K, Denisenko O, Wang Y.

Kidney Int. 2018 Jun; 6(93)1272-1275

Research Summary

Detrimental epigenetic processes are emerging as major pathophysiologic culprits of disease including cancer, inflammation, infection and organ injury. These processes involve signaling, transcription and epigenetic factors that regulate gene transcription in the chromatin environment, or the epigenome. To better define epigenetic processes in health and disease, our laboratory has been developing high throughput and sensitivity epigenetic platforms and computational tools and have applied them to study acute organ injury, cancer and inflammation.