Microbiology, Infection & Immunity
Virology and Immunology; Virus/host evolution; HIV infection and pathogenesis
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The Overbaugh lab has a long-standing interest in understanding the mechanisms of HIV transmission and pathogenesis. Studies include defining the role of both host and viral factors in transmission biology, including the innate and adaptive immune responses. Her lab is studying the evolutionary pathways that lead to the development of HIV-specific antibodies and the role that these antibodies play in protection from infection. Much of the HIV research in the lab is focused on populations in Africa where the AIDS epidemic is most severe.