faculty

Stephen Tapscott

stapscot@fredhutch.org
Member

Fred Hutch

Human Biology

Cancer Biology

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Gene transcription and chromatin in development and disease

Faculty Contact Information

Building: Hutchinson Building, FHCRC Room: C3-023 Box: FHCRC C3-168 Phone: 206-667-4499 https://research.fhcrc.org/tapscott/en.html

Research Summary

The Tapscott lab studies transcription factors that specify a cell lineage and seeks to determine the mechanisms and rules for establishing cellular identity, and to apply this knowledge to human development and disease. Studies of the MyoD and NeuroD families of transcription factors has identified both transcriptional and epigenetic components of cell specification and is being applied to models of cancer. Studies of the DUX4 transcription factor are revealing mechanisms and treatments for muscular dystrophy, the basis for early stem cell development, and immune evasion in cancers.

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