Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Gene transcription and chromatin in development and disease
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The Tapscott lab studies transcription factors that specify a cell lineage and seeks to determine the mechanisms and rules for establishing cellular identity, and to apply this knowledge to human development and disease. Studies of the MyoD and NeuroD families of transcription factors has identified both transcriptional and epigenetic components of cell specification and is being applied to models of cancer. Studies of the DUX4 transcription factor is revealing mechanisms and therapeutic opportunities in muscular dystrophy, and identifying the basis for early stem cell development.