University of Washington,
Gene Expression, Cell Cycle & Chromosome Biology
Choreography of eukaryotic DNA replication
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DNA replication is undeniably important for life and, as a consequence, cells have evolved mechanisms to monitor replication fidelity and to coordinate completion of replication with other cell cycle events. Using yeast as a model organism, we study how cells choreograph the duplication of their chromosomes, and how defects in initiation of DNA replication contribute to genetic disorders such as the human Meier-Gorlin Syndrome and the mouse chaos3 cancer phenotype. We also are exploring how errors at replication forks contribute to segmental copy number variants that improve fitness.
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Building: South Foege
Alt Phone: 206-543-9446