faculty

Clemens Cabernard

ccabern@uw.edu

University of Washington, 

Cancer Biology

Developmental Biology, Stem Cells & Aging

Gene Expression, Cell Cycle & Chromosome Biology

Molecular cell biology and mechanics of asymmetric cell division

Faculty Contact Information

Building: Life Science Building (LSB) Room: LSB361 Phone: 206-616-7368 https://www.biology.washington.edu/people/profile/clemens-cabernard

Lab Information

Location: Department of Biology Building: LSB Room: LSB3 Phone: 206-616-7368 https://www.cabernardlab.org/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

Mechanics of cell division and cytokinesis.

Canman JC, Cabernard C.

Molecular biology of the cell. 2018; 29(6):685-686.

PubMed [journal]
PMID:
29535170
PMCID:
PMC6003228

Drosophila scribble mutant tumors undergo a transition from a growth arrest state to a proliferative state over time

Ji T.

bioRxiv. 2018;

My Bibliography [journal]

Spatiotemporally controlled Myosin relocalization and internal pressure cause biased cortical extension to generate sibling cell size asymmetry

Pham T.

bioRxiv. 2018;

My Bibliography [journal]

A centrosome asymmetry switch in fly neural stem cells

Gallaud E.

bioRxiv. 2018;

My Bibliography [journal]

Spatio-temporally separated cortical flows and spindle geometry establish physical asymmetry in fly neural stem cells.

Roubinet C, Tsankova A, Pham TT, Monnard A, Caussinus E, Affolter M, Cabernard C.

Nature communications. 2017; 8(1):1383.

PubMed [journal]
PMID:
29123099
PMCID:
PMC5680339

Research Summary

My lab is studying asymmetric cell division (ACD), a process that generates cellular diversity.
We are using fly neural stem cells as a model to study the molecular cell biology and mechanics of asymmetric stem cell division. Our current research focus is on (1) the molecular mechanisms underlying the establishment and maintenance of centrosome asymmetry and biased centrosome segregation. (2) Cell cortex dynamics and cleavage furrow positioning during asymmetric cell division. (3) Mechanical and biophysical mechanisms involved in ACD.