Hao Yuan Kueh
kueh@uw.eduUniversity of Washington,
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Microbiology, Infection & Immunity
Molecular circuits controlling immune cell fate decisions
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment.
Ng KK, Yui MA, Mehta A, Siu S, Irwin B, Pease S, Hirose S, Elowitz MB, Rothenberg EV, Kueh HY.
Elife. 2018 Nov 20; (7)
Bcl11b and combinatorial resolution of cell fate in the T-cell gene regulatory network.
Longabaugh WJR, Zeng W, Zhang JA, Hosokawa H, Jansen CS, Li L, Romero-Wolf M, Liu P, Kueh HY, Mortazavi A, Rothenberg EV.
Proc Natl Acad Sci U S A. 2017 Jun 6; 23(114)5800-5807
Kueh HY, Zhu Y, Shi J.
Sci Rep. 2016 Nov 4; (6)36585
Manesso E, Kueh HY, Freedman G, Rothenberg EV, Peterson C.
PLoS One. 2016; 8(11)e0161260
Asynchronous combinatorial action of four regulatory factors activates Bcl11b for T cell commitment.
Kueh HY, Yui MA, Ng KK, Pease SS, Zhang JA, Damle SS, Freedman G, Siu S, Bernstein ID, Elowitz MB, Rothenberg EV.
Nat Immunol. 2016 Aug; 8(17)956-65
Hematopoiesis and T-cell specification as a model developmental system.
Rothenberg EV, Kueh HY, Yui MA, Zhang JA.
Immunol Rev. 2016 May; 1(271)72-97
Rothenberg EV, Champhekar A, Damle S, Del Real MM, Kueh HY, Li L, Yui MA.
Cold Spring Harb Symp Quant Biol. 2013; (78)31-41
Positive feedback between PU.1 and the cell cycle controls myeloid differentiation.
Kueh HY, Champhekar A, Nutt SL, Elowitz MB, Rothenberg EV.
Science. 2013 Aug 9; 6146(341)670-3
A far downstream enhancer for murine Bcl11b controls its T-cell specific expression.
Li L, Zhang JA, Dose M, Kueh HY, Mosadeghi R, Gounari F, Rothenberg EV.
Blood. 2013 Aug 8; 6(122)902-11
Maintenance of mitochondrial oxygen homeostasis by cosubstrate compensation.
Kueh HY, Niethammer P, Mitchison TJ.
Biophys J. 2013 Mar 19; 6(104)1338-48
Manesso E, Chickarmane V, Kueh HY, Rothenberg EV, Peterson C.
J R Soc Interface. 2013 Jan 6; 78(10)20120774
Regulatory gene network circuits underlying T cell development from multipotent progenitors.
Kueh HY, Rothenberg EV.
Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb; 1(4)79-102
Actin behavior in bulk cytoplasm is cell cycle regulated in early vertebrate embryos.
Field CM, Wühr M, Anderson GA, Kueh HY, Strickland D, Mitchison TJ.
J Cell Sci. 2011 Jun 15; Pt 12(124)2086-95
Kueh HY, Brieher WM, Mitchison TJ.
Biophys J. 2010 Oct 6; 7(99)2153-62
Structural plasticity in actin and tubulin polymer dynamics.
Kueh HY, Mitchison TJ.
Science. 2009 Aug 21; 5943(325)960-3
Dynamic stabilization of actin filaments.
Kueh HY, Brieher WM, Mitchison TJ.
Proc Natl Acad Sci U S A. 2008 Oct 28; 43(105)16531-6
Kueh HY, Charras GT, Mitchison TJ, Brieher WM.
J Cell Biol. 2008 Jul 28; 2(182)341-53
Spatial patterning of metabolism by mitochondria, oxygen, and energy sinks in a model cytoplasm.
Niethammer P, Kueh HY, Mitchison TJ.
Curr Biol. 2008 Apr 22; 8(18)586-91
Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH.
J Mol Biol. 2008 Feb 22; 3(376)607-13
Intrinsic fluctuations, robustness, and tunability in signaling cycles.
Levine J, Kueh HY, Mirny L.
Biophys J. 2007 Jun 15; 12(92)4473-81
Brieher WM, Kueh HY, Ballif BA, Mitchison TJ.
J Cell Biol. 2006 Oct 23; 2(175)315-24
Brain architecture and social complexity in modern and ancient birds.
Burish MJ, Kueh HY, Wang SS.
Brain Behav Evol. 2004; 2(63)107-24
Mechanisms of noise-resistance in genetic oscillators.
Vilar JM, Kueh HY, Barkai N, Leibler S.
Proc Natl Acad Sci U S A. 2002 Apr 30; 9(99)5988-92
Research Summary
Our lab studies how immune cells make fate decisions, both as they develop from stem cells, and as they respond to antigens. To understand the molecular circuitry controlling immune cell fate choice, we follow its dynamic behavior at the single-cell level using live imaging, uncover its molecular components using modern genetic, biochemical and high-throughput approaches, and elucidate underlying design principles using mathematical modeling. Through this work, we aim to lay foundations for engineering immune cells to fight disease.