Hao Yuan Kuehkueh@uw.edu
University of Washington,
Developmental Biology, Stem Cells & Aging
Gene Expression, Cell Cycle & Chromosome Biology
Microbiology, Infection & Immunity
Molecular circuits controlling immune cell fate decisions
Faculty Contact Information
Our lab studies how immune cells make fate decisions, both as they develop from stem cells, and as they respond to antigens. To understand the molecular circuitry controlling immune cell fate choice, we follow its dynamic behavior at the single-cell level using live imaging, uncover its molecular components using modern genetic, biochemical and high-throughput approaches, and elucidate underlying design principles using mathematical modeling. Through this work, we aim to lay foundations for engineering immune cells to fight disease.
The following publications were retrieved from PubMed:
Nguyen P, Pease NA, Kueh HY.
J R Soc Interface. 2021 Jul; 180(18)20210109
Woodworth MA, Ng KKH, Halpern AR, Pease NA, Nguyen PHB, Kueh HY, Vaughan JC.
Nucleic Acids Res. 2021 May 28;
Pease NA, Nguyen PHB, Woodworth MA, Ng KKH, Irwin B, Vaughan JC, Kueh HY.
Cell Rep. 2021 Mar 23; 12(34)108888
Chu JM, Pease NA, Kueh HY.
Immunol Rev. 2021 Mar; 1(300)134-151
Eastman AE, Chen X, Hu X, Hartman AA, Pearlman Morales AM, Yang C, Lu J, Kueh HY, Guo S.
Cell Rep. 2020 Jun 23; 12(31)107804
Abadie K, Pease NA, Wither MJ, Kueh HY.
Curr Opin Syst Biol. 2019 Dec; (18)95-103
Ng KK, Yui MA, Mehta A, Siu S, Irwin B, Pease S, Hirose S, Elowitz MB, Rothenberg EV, Kueh HY.
Elife. 2018 Nov 20; (7)
Longabaugh WJR, Zeng W, Zhang JA, Hosokawa H, Jansen CS, Li L, Romero-Wolf M, Liu P, Kueh HY, Mortazavi A, Rothenberg EV.
Proc Natl Acad Sci U S A. 2017 Jun 6; 23(114)5800-5807
Kueh HY, Zhu Y, Shi J.
Sci Rep. 2016 Nov 4; (6)36585
Manesso E, Kueh HY, Freedman G, Rothenberg EV, Peterson C.
PLoS One. 2016; 8(11)e0161260
Kueh HY, Yui MA, Ng KK, Pease SS, Zhang JA, Damle SS, Freedman G, Siu S, Bernstein ID, Elowitz MB, Rothenberg EV.
Nat Immunol. 2016 Aug; 8(17)956-65
Rothenberg EV, Kueh HY, Yui MA, Zhang JA.
Immunol Rev. 2016 May; 1(271)72-97
Rothenberg EV, Champhekar A, Damle S, Del Real MM, Kueh HY, Li L, Yui MA.
Cold Spring Harb Symp Quant Biol. 2013; (78)31-41
Kueh HY, Champhekar A, Nutt SL, Elowitz MB, Rothenberg EV.
Science. 2013 Aug 9; 6146(341)670-3
Li L, Zhang JA, Dose M, Kueh HY, Mosadeghi R, Gounari F, Rothenberg EV.
Blood. 2013 Aug 8; 6(122)902-11
Kueh HY, Niethammer P, Mitchison TJ.
Biophys J. 2013 Mar 19; 6(104)1338-48
Manesso E, Chickarmane V, Kueh HY, Rothenberg EV, Peterson C.
J R Soc Interface. 2013 Jan 6; 78(10)20120774
Kueh HY, Rothenberg EV.
Wiley Interdiscip Rev Syst Biol Med. 2012 Jan-Feb; 1(4)79-102
Field CM, Wühr M, Anderson GA, Kueh HY, Strickland D, Mitchison TJ.
J Cell Sci. 2011 Jun 15; Pt 12(124)2086-95
Kueh HY, Brieher WM, Mitchison TJ.
Biophys J. 2010 Oct 6; 7(99)2153-62
Kueh HY, Mitchison TJ.
Science. 2009 Aug 21; 5943(325)960-3
Kueh HY, Brieher WM, Mitchison TJ.
Proc Natl Acad Sci U S A. 2008 Oct 28; 43(105)16531-6
J Vis Exp. 2006 Nov 8; 166
Kueh HY, Charras GT, Mitchison TJ, Brieher WM.
J Cell Biol. 2008 Jul 28; 2(182)341-53
Niethammer P, Kueh HY, Mitchison TJ.
Curr Biol. 2008 Apr 22; 8(18)586-91
Galkin VE, Orlova A, Brieher W, Kueh HY, Mitchison TJ, Egelman EH.
J Mol Biol. 2008 Feb 22; 3(376)607-13
Levine J, Kueh HY, Mirny L.
Biophys J. 2007 Jun 15; 12(92)4473-81
Brieher WM, Kueh HY, Ballif BA, Mitchison TJ.
J Cell Biol. 2006 Oct 23; 2(175)315-24
Burish MJ, Kueh HY, Wang SS.
Brain Behav Evol. 2004; 2(63)107-24
Vilar JM, Kueh HY, Barkai N, Leibler S.
Proc Natl Acad Sci U S A. 2002 Apr 30; 9(99)5988-92