University of Washington,
Gene Expression, Cell Cycle & Chromosome Biology
Genetics, Genomics & Evolution (Area Director)
Microbiology, Infection & Immunity
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A fundamental issue facing modern biology is the development of methods and tools to convert genomics and function genomics data into mechanistic understanding. Genome sequences and computational methods have provided us with tools to identify and annotate genes and other functional sequences with varying degrees of accuracy. Annotated sequence information in turn enables tools such as RNA-Seq, microarrays, 2-D gels, protein mass spectrometry and yeast 2-hybrids to measure RNA and protein levels and physical interactions on genome-wide or near genome-wide scales.