University of Washington,
Cell Signaling & Cell/Environment Interactions
Microbiology, Infection & Immunity (Area Director)
Inflammatory cell death, and its consequences
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Programmed cell death–cell suicide–is a fundamental biological process. We now understand that cells can kill themselves in several different ways, and that how a cell dies is a key determinant of the immune response generated by that dying cell. The Oberst lab studies how inflammatory forms of cell suicide occur, and how they affect the immune response to pathogens, cancer cells, and auto-antigens.