faculty

Andrew Oberst

oberst@uw.edu

Associate Professor

University of Washington

Immunology

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity (Area Director)

Inflammatory cell death, and its consequences

Faculty Contact Information

Room: E306, UW South Lake Union Box: 358059 Phone: 221-731 http://immunology.washington.edu/andrew-oberst-phd

Research Summary

Programmed cell death–cell suicide–is a fundamental biological process. We now understand that cells can kill themselves in several different ways, and that how a cell dies is a key determinant of the immune response generated by that dying cell. The Oberst lab studies how inflammatory forms of cell suicide occur, and how they affect the immune response to pathogens, cancer cells, and auto-antigens.

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Publications

The following publications were retrieved from PubMed:

The Antisocial Network: Cross Talk Between Cell Death Programs in Host Defense.

Snyder AG, Oberst A.

Annu Rev Immunol. 2021 Apr 26; (39)77-101

De novo necroptosis creates an inflammatory environment mediating tumor susceptibility to immune checkpoint inhibitors.

Workenhe ST, Nguyen A, Bakhshinyan D, Wei J, Hare DN, MacNeill KL, Wan Y, Oberst A, Bramson JL, Nasir JA, Vito A, El-Sayes N, Singh SK, McArthur AG, Mossman KL.

Commun Biol. 2020 Nov 4; 1(3)645

Identification of MYC as an antinecroptotic protein that stifles RIPK1-RIPK3 complex formation.

Seong D, Jeong M, Seo J, Lee JY, Hwang CH, Shin HC, Shin JY, Nam YW, Jo JY, Lee H, Kim HJ, Kim HR, Oh JH, Ha SJ, Kim SJ, Roe JS, Kim W, Cheong JW, Bae KH, Lee SC, Oberst A, Vandenabeele P, Shin DH, Lee EW, Song J.

Proc Natl Acad Sci U S A. 2020 Aug 18; 33(117)19982-19993

Outcomes of RIP Kinase Signaling During Neuroinvasive Viral Infection.

Daniels BP, Oberst A.

Curr Top Microbiol Immunol. 2020 Apr 7;

T cells instruct myeloid cells to produce inflammasome-independent IL-1β and cause autoimmunity.

Jain A, Irizarry-Caro RA, McDaniel MM, Chawla AS, Carroll KR, Overcast GR, Philip NH, Oberst A, Chervonsky AV, Katz JD, Pasare C.

Nat Immunol. 2020 Jan; 1(21)65-74

Accepting Students For:

Rotation, Autumn

Rotation, Spring

Rotation, Summer

Rotation, Winter

Lab Information

Location: University of Washington
Building: South Lake Union
Room: E 310
Phone: 221-731