faculty

Andrew Oberst

oberst@uw.edu
Associate Professor

University of Washington

Immunology

Cancer Biology

Cell Signaling & Cell/Environment Interactions

Microbiology, Infection & Immunity (Area Director)

Inflammatory cell death, and its consequences

Faculty Contact Information

Room: E306, UW South Lake Union Box: 358059 Phone: 221-731 http://immunology.washington.edu/andrew-oberst-phd

Research Summary

Programmed cell death–cell suicide–is a fundamental biological process. We now understand that cells can kill themselves in several different ways, and that how a cell dies is a key determinant of the immune response generated by that dying cell. The Oberst lab studies how inflammatory forms of cell suicide occur, and how they affect the immune response to pathogens, cancer cells, and auto-antigens.

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Publications

The following publications were retrieved from PubMed:

RIPK3 Activation Leads to Cytokine Synthesis that Continues after Loss of Cell Membrane Integrity.

Orozco SL, Daniels BP, Yatim N, Messmer MN, Quarato G, Chen-Harris H, Cullen SP, Snyder AG, Ralli-Jain P, Frase S, Tait SWG, Green DR, Albert ML, Oberst A.

Cell Rep. 2019 Aug 27; 9(28)2275-2287.e5

STING is required for host defense against neuropathological West Nile virus infection.

McGuckin Wuertz K, Treuting PM, Hemann EA, Esser-Nobis K, Snyder AG, Graham JB, Daniels BP, Wilkins C, Snyder JM, Voss KM, Oberst A, Lund J, Gale M Jr.

PLoS Pathog. 2019 Aug; 8(15)e1007899

Intratumoral activation of the necroptotic pathway components RIPK1 and RIPK3 potentiates antitumor immunity.

Snyder AG, Hubbard NW, Messmer MN, Kofman SB, Hagan CE, Orozco SL, Chiang K, Daniels BP, Baker D, Oberst A.

Sci Immunol. 2019 Jun 21; 36(4)

The Nucleotide Sensor ZBP1 and Kinase RIPK3 Induce the Enzyme IRG1 to Promote an Antiviral Metabolic State in Neurons.

Daniels BP, Kofman SB, Smith JR, Norris GT, Snyder AG, Kolb JP, Gao X, Locasale JW, Martinez J, Gale M Jr, Loo YM, Oberst A.

Immunity. 2019 Jan 15; 1(50)64-76.e4

Comparing the effects of different cell death programs in tumor progression and immunotherapy.

Messmer MN, Snyder AG, Oberst A.

Cell Death Differ. 2019 Jan; 1(26)115-129

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter

Lab Information

Location: University of Washington
Building: South Lake Union
Room: E 310
Phone: 221-731