Andrew Oberst
oberst@uw.eduUniversity of Washington,
Cancer Biology
Cell Signaling & Cell/Environment Interactions
Microbiology, Infection & Immunity (Area Director)
Inflammatory cell death, and its consequences
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
Comparing the effects of different cell death programs in tumor progression and immunotherapy.
Messmer MN, Snyder AG, Oberst A.
Cell Death Differ. 2018 Oct 19;
Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis.
Riley JS, Quarato G, Cloix C, Lopez J, O'Prey J, Pearson M, Chapman J, Sesaki H, Carlin LM, Passos JF, Wheeler AP, Oberst A, Ryan KM, Tait SW.
EMBO J. 2018 Sep 3; 17(37)
Brault M, Olsen TM, Martinez J, Stetson DB, Oberst A.
J Immunol. 2018 Apr 15; 8(200)2748-2756
Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.
Cell Death Differ. 2018 Mar; 3(25)486-541
Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, Roca A, Lopez J, Ichim G, Proïcs E, Rubio-Patiño C, Fort L, Yatim N, Woodham E, Orozco S, Taraborrelli L, Peltzer N, Lecis D, Machesky L, Walczak H, Albert ML, Milling S, Oberst A, Ricci JE, Ryan KM, Blyth K, Tait SWG.
Nat Cell Biol. 2017 Sep; 9(19)1116-1129
Programmed Cell Death and Inflammation: Winter Is Coming.
Kolb JP, Oguin TH 3rd, Oberst A, Martinez J.
Trends Immunol. 2017 Oct; 10(38)705-718
RIPK3 in cell death and inflammation: the good, the bad, and the ugly.
Orozco S, Oberst A.
Immunol Rev. 2017 May; 1(277)102-112
NPM1 directs PIDDosome-dependent caspase-2 activation in the nucleolus.
Ando K, Parsons MJ, Shah RB, Charendoff CI, Paris SL, Liu PH, Fassio SR, Rohrman BA, Thompson R, Oberst A, Sidi S, Bouchier-Hayes L.
J Cell Biol. 2017 Jun 5; 6(216)1795-1810
RIPK3 Restricts Viral Pathogenesis via Cell Death-Independent Neuroinflammation.
Daniels BP, Snyder AG, Olsen TM, Orozco S, Oguin TH 3rd, Tait SWG, Martinez J, Gale M Jr, Loo YM, Oberst A.
Cell. 2017 Apr 6; 2(169)301-313.e11
Gutierrez KD, Davis MA, Daniels BP, Olsen TM, Ralli-Jain P, Tait SW, Gale M Jr, Oberst A.
J Immunol. 2017 Mar 1; 5(198)2156-2164
Necroptosis in development, inflammation and disease.
Weinlich R, Oberst A, Beere HM, Green DR.
Nat Rev Mol Cell Biol. 2017 Feb; 2(18)127-136
Controlled detonation: evolution of necroptosis in pathogen defense.
Brault M, Oberst A.
Immunol Cell Biol. 2017 Feb; 2(95)131-136
Philip NH, DeLaney A, Peterson LW, Santos-Marrero M, Grier JT, Sun Y, Wynosky-Dolfi MA, Zwack EE, Hu B, Olsen TM, Rongvaux A, Pope SD, López CB, Oberst A, Beiting DP, Henao-Mejia J, Brodsky IE.
PLoS Pathog. 2016 Oct; 10(12)e1005910
Nogusa S, Thapa RJ, Dillon CP, Liedmann S, Oguin TH 3rd, Ingram JP, Rodriguez DA, Kosoff R, Sharma S, Sturm O, Verbist K, Gough PJ, Bertin J, Hartmann BM, Sealfon SC, Kaiser WJ, Mocarski ES, López CB, Thomas PG, Oberst A, Green DR, Balachandran S.
Cell Host Microbe. 2016 Jul 13; 1(20)13-24
Mito-priming as a method to engineer Bcl-2 addiction.
Lopez J, Bessou M, Riley JS, Giampazolias E, Todt F, Rochegüe T, Oberst A, Green DR, Edlich F, Ichim G, Tait SW.
Nat Commun. 2016 Feb 2; (7)10538
RIPK1 and NF-κB signaling in dying cells determines cross-priming of CD8⁺ T cells.
Yatim N, Jusforgues-Saklani H, Orozco S, Schulz O, Barreira da Silva R, Reis e Sousa C, Green DR, Oberst A, Albert ML.
Science. 2015 Oct 16; 6258(350)328-34
Caspase-8 scaffolding function and MLKL regulate NLRP3 inflammasome activation downstream of TLR3.
Kang S, Fernandes-Alnemri T, Rogers C, Mayes L, Wang Y, Dillon C, Roback L, Kaiser W, Oberst A, Sagara J, Fitzgerald KA, Green DR, Zhang J, Mocarski ES, Alnemri ES.
Nat Commun. 2015 Jun 24; (6)7515
Rodriguez DA, Weinlich R, Brown S, Guy C, Fitzgerald P, Dillon CP, Oberst A, Quarato G, Low J, Cripps JG, Chen T, Green DR.
Cell Death Differ. 2016 Jan; 1(23)76-88
Ichim G, Lopez J, Ahmed SU, Muthalagu N, Giampazolias E, Delgado ME, Haller M, Riley JS, Mason SM, Athineos D, Parsons MJ, van de Kooij B, Bouchier-Hayes L, Chalmers AJ, Rooswinkel RW, Oberst A, Blyth K, Rehm M, Murphy DJ, Tait SWG.
Mol Cell. 2015 Mar 5; 5(57)860-872
Ubiquitination and proteasomal degradation of ATG12 regulates its proapoptotic activity.
Haller M, Hock AK, Giampazolias E, Oberst A, Green DR, Debnath J, Ryan KM, Vousden KH, Tait SW.
Autophagy. 2014; 12(10)2269-78
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015.
Galluzzi L, Bravo-San Pedro JM, Vitale I, Aaronson SA, Abrams JM, Adam D, Alnemri ES, Altucci L, Andrews D, Annicchiarico-Petruzzelli M, Baehrecke EH, Bazan NG, Bertrand MJ, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Bredesen DE, Brenner C, Campanella M, Candi E, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, Di Daniele N, Dixit VM, Dynlacht BD, El-Deiry WS, Fimia GM, Flavell RA, Fulda S, Garrido C, Gougeon ML, Green DR, Gronemeyer H, Hajnoczky G, Hardwick JM, Hengartner MO, Ichijo H, Joseph B, Jost PJ, Kaufmann T, Kepp O, Klionsky DJ, Knight RA, Kumar S, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lugli E, Madeo F, Malorni W, Marine JC, Martin SJ, Martinou JC, Medema JP, Meier P, Melino S, Mizushima N, Moll U, Muñoz-Pinedo C, Nuñez G, Oberst A, Panaretakis T, Penninger JM, Peter ME, Piacentini M, Pinton P, Prehn JH, Puthalakath H, Rabinovich GA, Ravichandran KS, Rizzuto R, Rodrigues CM, Rubinsztein DC, Rudel T, Shi Y, Simon HU, Stockwell BR, Szabadkai G, Tait SW, Tang HL, Tavernarakis N, Tsujimoto Y, Vanden Berghe T, Vandenabeele P, Villunger A, Wagner EF, Walczak H, White E, Wood WG, Yuan J, Zakeri Z, Zhivotovsky B, Melino G, Kroemer G.
Cell Death Differ. 2015 Jan; 1(22)58-73
RIPK1 both positively and negatively regulates RIPK3 oligomerization and necroptosis.
Orozco S, Yatim N, Werner MR, Tran H, Gunja SY, Tait SW, Albert ML, Green DR, Oberst A.
Cell Death Differ. 2014 Oct; 10(21)1511-21
Philip NH, Dillon CP, Snyder AG, Fitzgerald P, Wynosky-Dolfi MA, Zwack EE, Hu B, Fitzgerald L, Mauldin EA, Copenhaver AM, Shin S, Wei L, Parker M, Zhang J, Oberst A, Green DR, Brodsky IE.
Proc Natl Acad Sci U S A. 2014 May 20; 20(111)7385-90
Autophagy controls the kinetics and extent of mitochondrial apoptosis by regulating PUMA levels.
Thorburn J, Andrysik Z, Staskiewicz L, Gump J, Maycotte P, Oberst A, Green DR, Espinosa JM, Thorburn A.
Cell Rep. 2014 Apr 10; 1(7)45-52
Shenderov K, Riteau N, Yip R, Mayer-Barber KD, Oland S, Hieny S, Fitzgerald P, Oberst A, Dillon CP, Green DR, Cerundolo V, Sher A.
J Immunol. 2014 Mar 1; 5(192)2029-2033
Widespread mitochondrial depletion via mitophagy does not compromise necroptosis.
Tait SW, Oberst A, Quarato G, Milasta S, Haller M, Wang R, Karvela M, Ichim G, Yatim N, Albert ML, Kidd G, Wakefield R, Frase S, Krautwald S, Linkermann A, Green DR.
Cell Rep. 2013 Nov 27; 4(5)878-85
Protective roles for caspase-8 and cFLIP in adult homeostasis.
Weinlich R, Oberst A, Dillon CP, Janke LJ, Milasta S, Lukens JR, Rodriguez DA, Gurung P, Savage C, Kanneganti TD, Green DR.
Cell Rep. 2013 Oct 31; 2(5)340-8
Survival function of the FADD-CASPASE-8-cFLIP(L) complex.
Dillon CP, Oberst A, Weinlich R, Janke LJ, Kang TB, Ben-Moshe T, Mak TW, Wallach D, Green DR.
Cell Rep. 2012 May 31; 5(1)401-7
Caspase 8 inhibits programmed necrosis by processing CYLD.
O'Donnell MA, Perez-Jimenez E, Oberst A, Ng A, Massoumi R, Xavier R, Green DR, Ting AT.
Nat Cell Biol. 2011 Oct 30; 12(13)1437-42
It cuts both ways: reconciling the dual roles of caspase 8 in cell death and survival.
Oberst A, Green DR.
Nat Rev Mol Cell Biol. 2011 Oct 21; 11(12)757-63
RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts.
Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS.
Mol Cell. 2011 Oct 7; 1(44)9-16
Martinez J, Almendinger J, Oberst A, Ness R, Dillon CP, Fitzgerald P, Hengartner MO, Green DR.
Proc Natl Acad Sci U S A. 2011 Oct 18; 42(108)17396-401
Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis.
Oberst A, Dillon CP, Weinlich R, McCormick LL, Fitzgerald P, Pop C, Hakem R, Salvesen GS, Green DR.
Nature. 2011 Mar 17; 7338(471)363-7
Pop C, Oberst A, Drag M, Van Raam BJ, Riedl SJ, Green DR, Salvesen GS.
Biochem J. 2011 Feb 1; 3(433)447-457
Oberst A, Pop C, Tremblay AG, Blais V, Denault JB, Salvesen GS, Green DR.
J Biol Chem. 2010 May 28; 22(285)16632-42
Characterization of cytoplasmic caspase-2 activation by induced proximity.
Bouchier-Hayes L, Oberst A, McStay GP, Connell S, Tait SW, Dillon CP, Flanagan JM, Beere HM, Green DR.
Mol Cell. 2009 Sep 24; 6(35)830-40
Tait SW, Bouchier-Hayes L, Oberst A, Connell S, Green DR.
Methods Mol Biol. 2009; (559)33-48
Living with death: the evolution of the mitochondrial pathway of apoptosis in animals.
Oberst A, Bender C, Green DR.
Cell Death Differ. 2008 Jul; 7(15)1139-46
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch.
Oberst A, Malatesta M, Aqeilan RI, Rossi M, Salomoni P, Murillas R, Sharma P, Kuehn MR, Oren M, Croce CM, Bernassola F, Melino G.
Proc Natl Acad Sci U S A. 2007 Jul 3; 27(104)11280-5
Bernassola F, Oberst A, Melino G, Pandolfi PP.
Oncogene. 2005 Oct 20; 46(24)6982-6
Regulation of the p73 protein stability and degradation.
Oberst A, Rossi M, Salomoni P, Pandolfi PP, Oren M, Melino G, Bernassola F.
Biochem Biophys Res Commun. 2005 Jun 10; 3(331)707-12
Ubiquitin-dependent degradation of p73 is inhibited by PML.
Bernassola F, Salomoni P, Oberst A, Di Como CJ, Pagano M, Melino G, Pandolfi PP.
J Exp Med. 2004 Jun 7; 11(199)1545-57
A place to die for: apoptosis in cancer and infection, Capri 2002.
Oberst A, Baehrecke E, Mehmet H, Ichijo H, Gupta S.
Cell Death Differ. 2003 Mar; 3(10)393-5
Calabria: sun, sand, and cell death.
Bagetta G, Corasaniti MT, Oberst A, Brüne B.
Cell Death Differ. 2002 Oct; 10(9)1158-9
Research Summary
Programmed cell death–cell suicide–is a fundamental biological process. We now understand that cells can kill themselves in several different ways, and that how a cell dies is a key determinant of the immune response generated by that dying cell. The Oberst lab studies how inflammatory forms of cell suicide occur, and how they affect the immune response to pathogens, cancer cells, and auto-antigens.