faculty

Douglas Fowler

dfowler@uw.edu
Associate Professor

University of Washington

Bioengineering

Biophysical and Structural Biology

Cancer Biology

New methods for understanding and editing genomes

Faculty Contact Information

Building: Foege Room: S320 Box: 355065 Phone: 221-571 http://fowlerlab.gs.washington.edu/

Research Summary

How does a protein’s sequence encode its fold and function? How do changes in sequence influence disease risk, prognosis and treatment? How do gene expression patterns combine with protein activity to define cellular processes like growth, migration and communication? We develop new ways to probe the relationship between genotype and phenotype, enabling us to better answer these questions. To accomplish this goal, we draw on our expertise in genomics, protein science, technology development and computational approaches.

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Publications

The following publications were retrieved from PubMed:

Multiplexed measurement of variant abundance and activity reveals VKOR topology, active site and human variant impact.

Chiasson MA, Rollins NJ, Stephany JJ, Sitko KA, Matreyek KA, Verby M, Sun S, Roth FP, DeSloover D, Marks DS, Rettie AE, Fowler DM.

Elife. 2020 Sep 1; (9)

Parallel Chemoselective Profiling for Mapping Protein Structure.

Potter ZE, Lau HT, Chakraborty S, Fang L, Guttman M, Ong SE, Fowler DM, Maly DJ.

Cell Chem Biol. 2020 Aug 20; 8(27)1084-1096.e4

High-throughput discovery of trafficking-deficient variants in the cardiac potassium channel KV11.1.

Kozek KA, Glazer AM, Ng CA, Blackwell D, Egly CL, Vanags LR, Blair M, Mitchell D, Matreyek KA, Fowler DM, Knollmann BC, Vandenberg JI, Roden DM, Kroncke BM.

Heart Rhythm. 2020 Jun 6;

High-throughput, microscope-based sorting to dissect cellular heterogeneity.

Hasle N, Cooke A, Srivatsan S, Huang H, Stephany JJ, Krieger Z, Jackson D, Tang W, Pendyala S, Monnat RJ Jr, Trapnell C, Hatch EM, Fowler DM.

Mol Syst Biol. 2020 Jun; 6(16)e9442

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