faculty

Douglas Fowler

dfowler@uw.edu
Associate Professor

University of Washington

Bioengineering

Biophysical and Structural Biology

Cancer Biology

Genetics, Genomics & Evolution

New methods for understanding and editing genomes

Faculty Contact Information

Building: Foege Room: S320 Box: 355065 Phone: 221-571 http://fowlerlab.gs.washington.edu/

Research Summary

How does a protein’s sequence encode its fold and function? How do changes in sequence influence disease risk, prognosis and treatment? How do gene expression patterns combine with protein activity to define cellular processes like growth, migration and communication? We develop new ways to probe the relationship between genotype and phenotype, enabling us to better answer these questions. To accomplish this goal, we draw on our expertise in genomics, protein science, technology development and computational approaches.

DEI Statement

Creating a welcoming, inclusive culture is the foundation for success. As a mentor, I strive to create such a culture in several ways. I work to develop a trusting, open relationship with each member of the lab by listening, understanding each person’s unique perspective and by advocating for them. I also work to create structures and norms within the lab that promote respectful discourse and create space for all. Finally, I work at the Departmental and UW-wide levels to remove systemic barriers to success.

Training Summary

DEI Training (Lavender Rights Project) – 2021

Culturally Aware Mentoring (NMRN/CIMER) – 2020

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/esummary.fcgi?db=pubmed&query_key=1&WebEnv=MCID_639159363b4c9d46804d79f9&retmode=json
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Publications

The following publications were retrieved from PubMed:

Environmental selection and epistasis in an empirical phenotype-environment-fitness landscape.

Chen JZ, Fowler DM, Tokuriki N.

Nat Ecol Evol. 2022 Apr; 4(6)427-438

Probing ion channel functional architecture and domain recombination compatibility by massively parallel domain insertion profiling.

Coyote-Maestas W, Nedrud D, Suma A, He Y, Matreyek KA, Fowler DM, Carnevale V, Myers CL, Schmidt D.

Nat Commun. 2021 Dec 8; 1(12)7114

Closing the gap: Systematic integration of multiplexed functional data resolves variants of uncertain significance in BRCA1, TP53, and PTEN.

Fayer S, Horton C, Dines JN, Rubin AF, Richardson ME, McGoldrick K, Hernandez F, Pesaran T, Karam R, Shirts BH, Fowler DM, Starita LM.

Am J Hum Genet. 2021 Dec 2; 12(108)2248-2258

Measuring Pharmacogene Variant Function at Scale Using Multiplexed Assays.

Geck RC, Boyle G, Amorosi CJ, Fowler DM, Dunham MJ.

Annu Rev Pharmacol Toxicol. 2022 Jan 6; (62)531-550

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