Research Summary
How does a protein’s sequence encode its fold and function? How do changes in sequence influence disease risk, prognosis and treatment? How do gene expression patterns combine with protein activity to define cellular processes like growth, migration and communication? We develop new ways to probe the relationship between genotype and phenotype, enabling us to better answer these questions. To accomplish this goal, we draw on our expertise in genomics, protein science, technology development and computational approaches.
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string(16) "2005/11/23 09:00"
}
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["pmcrefcount"]=>
int(245)
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string(12) "PLoS biology"
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Publications
The following publications were retrieved from PubMed:
Massively parallel variant characterization identifies <i>NUDT15</i> alleles associated with thiopurine toxicity.
Suiter CC, Moriyama T, Matreyek KA, Yang W, Scaletti ER, Nishii R, Yang W, Hoshitsuki K, Singh M, Trehan A, Parish C, Smith C, Li L, Bhojwani D, Yuen LYP, Li CK, Li CH, Yang YL, Walker GJ, Goodhand JR, Kennedy NA, Klussmann FA, Bhatia S, Relling MV, Kato M, Hori H, Bhatia P, Ahmad T, Yeoh AEJ, Stenmark P, Fowler DM, Yang JJ.
Proc Natl Acad Sci U S A. 2020 Mar 10; 10(117)5394-5401
