University of Washington,
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Mechanosensory hair cell development, death and regeneration
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Hair cells of the inner ear conver mechanical stimuli to electrical signals transmitted to the brain. Damage and loss of hair cells are leading causes of hearing and balance disorders, affecting over 40 million people in the US. Hair cell loss in humans is irreversible, however they regenerate in other species. We use the zebrafish to study hair cell development, death and regeneration using genetics, genome editing, high resolution imaging and small molecule screening.