faculty

Dave Raible

draible@uw.edu
Professor

University of Washington

Biological Structure

Developmental Biology, Stem Cells & Aging

Genetics, Genomics & Evolution

Neuroscience

Mechanosensory hair cell development, death and regeneration

Faculty Contact Information

Building: Health Sciences Building Room: H-501 Box: Box 357420 Phone: 206-616-1048

Research Summary

Hair cells of the inner ear conver mechanical stimuli to electrical signals transmitted to the brain. Damage and loss of hair cells are leading causes of hearing and balance disorders, affecting over 40 million people in the US. Hair cell loss in humans is irreversible, however they regenerate in other species. We use the zebrafish to study hair cell development, death and regeneration using genetics, genome editing, high resolution imaging and small molecule screening.

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Publications

The following publications were retrieved from PubMed:

ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity.

Kitcher SR, Kirkwood NK, Camci ED, Wu P, Gibson RM, Redila VA, Simon JA, Rubel EW, Raible DW, Richardson GP, Kros CJ.

JCI Insight. 2019 Aug 8; 15(4)

Fate plasticity and reprogramming in genetically distinct populations of <i>Danio</i> leucophores.

Lewis VM, Saunders LM, Larson TA, Bain EJ, Sturiale SL, Gur D, Chowdhury S, Flynn JD, Allen MC, Deheyn DD, Lee JC, Simon JA, Lippincott-Schwartz J, Raible DW, Parichy DM.

Proc Natl Acad Sci U S A. 2019 Jun 11; 24(116)11806-11811

Water Waves to Sound Waves: Using Zebrafish to Explore Hair Cell Biology.

Pickett SB, Raible DW.

J Assoc Res Otolaryngol. 2019 Feb; 1(20)1-19

Cumulative mitochondrial activity correlates with ototoxin susceptibility in zebrafish mechanosensory hair cells.

Pickett SB, Thomas ED, Sebe JY, Linbo T, Esterberg R, Hailey DW, Raible DW.

Elife. 2018 Dec 31; (7)

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Lab Information

Location: University of Washington
Building: HSB
Room: H-502
Box: Box 357420
http://raibleweb.biostr.washington.edu/