faculty

Dave Raible (he, him)

draible@uw.edu

Professor

University of Washington

Biological Structure

Developmental Biology, Stem Cells & Aging

Genetics, Genomics & Evolution

Neuroscience

Mechanosensory hair cell development, death and regeneration

Faculty Contact Information

Building: Health Sciences Building Room: H-501 Box: Box 357420 Phone: 206-616-1048

Research Summary

Hair cells of the inner ear conver mechanical stimuli to electrical signals transmitted to the brain. Damage and loss of hair cells are leading causes of hearing and balance disorders, affecting over 40 million people in the US. Hair cell loss in humans is irreversible, however they regenerate in other species. We use the zebrafish to study hair cell development, death and regeneration. We take an interdisciplinary approach that uses genetics, genome editing, single cell profiling, high resolution imaging, small molecule screening and computational modeling.

DEI Statement

The Raible lab values equity and inclusion and strives to provide a welcoming environment for trainees from diverse backgrounds. We recognize that oppressive policies create barriers that prevent the entry and participation of underrepresented groups, hindering the advancement of science. We provide resources to empower trainees and support their progression through their scientific careers.

Training Summary

2019: University of Wisconsin CIMER Mentoring: organized a two day workshop in Seattle for faculty mentoring.

2020: University of Wisconsin CIMER training on Culturally Aware Mentoring: explored how one’s cultural heritage impacts mentoring

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Publications

The following publications were retrieved from PubMed:

Losing the license to regenerate hair cells.

Beaulieu MO, Raible DW.

Dev Cell. 2021 Sep 13; 17(56)2402-2404

Chloroquine kills hair cells in zebrafish lateral line and murine cochlear cultures: Implications for ototoxicity.

Davis SN, Wu P, Camci ED, Simon JA, Rubel EW, Raible DW.

Hear Res. 2020 Sep 15; (395)108019

ORC-13661 protects sensory hair cells from aminoglycoside and cisplatin ototoxicity.

Kitcher SR, Kirkwood NK, Camci ED, Wu P, Gibson RM, Redila VA, Simon JA, Rubel EW, Raible DW, Richardson GP, Kros CJ.

JCI Insight. 2019 Aug 8; 15(4)

Fate plasticity and reprogramming in genetically distinct populations of Danio leucophores.

Lewis VM, Saunders LM, Larson TA, Bain EJ, Sturiale SL, Gur D, Chowdhury S, Flynn JD, Allen MC, Deheyn DD, Lee JC, Simon JA, Lippincott-Schwartz J, Raible DW, Parichy DM.

Proc Natl Acad Sci U S A. 2019 Jun 11; 24(116)11806-11811

Distinct progenitor populations mediate regeneration in the zebrafish lateral line.

Thomas ED, Raible DW.

Elife. 2019 Mar 5; (8)

Accepting Students For:

Rotation, Autumn

Rotation, Spring

Rotation, Summer

Rotation, Winter

Permanent

Lab Information

Location: University of Washington
Building: HSB
Room: H-502
Box: Box 357420
https://faculty.washington.edu/draible/