faculty

Dave Raible

draible@uw.edu

University of Washington, 

Developmental Biology, Stem Cells & Aging

Genetics, Genomics & Evolution

Neuroscience

Mechanosensory hair cell development, death and regeneration

Faculty Contact Information

Building: Health Sciences Building Room: H-501 Box: Box 357420 Phone: 206-616-1048

Lab Information

Location: University of Washington Building: HSB Room: H-502 Box: Box 357420 http://raibleweb.biostr.washington.edu/

Accepting Students For:

Rotation, Autumn
Rotation, Spring
Rotation, Summer
Rotation, Winter
Permanent

Publications

The following publications were retrieved from PubMed:

Water Waves to Sound Waves: Using Zebrafish to Explore Hair Cell Biology.

Pickett SB, Raible DW.

J Assoc Res Otolaryngol. 2019 Feb; 1(20)1-19

Cumulative mitochondrial activity correlates with ototoxin susceptibility in zebrafish mechanosensory hair cells.

Pickett SB, Thomas ED, Sebe JY, Linbo T, Esterberg R, Hailey DW, Raible DW.

Elife. 2018 Dec 31; (7)

The role of retrograde intraflagellar transport genes in aminoglycoside-induced hair cell death.

Stawicki TM, Linbo T, Hernandez L, Parkinson L, Bellefeuille D, Rubel EW, Raible DW.

Biol Open. 2019 Jan 14; 1(8)

The Inner Ear Heat Shock Transcriptional Signature Identifies Compounds That Protect Against Aminoglycoside Ototoxicity.

Ryals M, Morell RJ, Martin D, Boger ET, Wu P, Raible DW, Cunningham LL.

Front Cell Neurosci. 2018; (12)445

Research Summary

Hair cells of the inner ear conver mechanical stimuli to electrical signals transmitted to the brain. Damage and loss of hair cells are leading causes of hearing and balance disorders, affecting over 40 million people in the US. Hair cell loss in humans is irreversible, however they regenerate in other species. We use the zebrafish to study hair cell development, death and regeneration using genetics, genome editing, high resolution imaging and small molecule screening.