Dave Raible
draible@uw.eduUniversity of Washington,
Developmental Biology, Stem Cells & Aging
Genetics, Genomics & Evolution
Neuroscience
Mechanosensory hair cell development, death and regeneration
Faculty Contact Information
Lab Information
Accepting Students For:
Publications
The following publications were retrieved from PubMed:
Distinct progenitor populations mediate regeneration in the zebrafish lateral line.
Thomas ED, Raible DW.
Elife. 2019 Mar 5; (8)
Water Waves to Sound Waves: Using Zebrafish to Explore Hair Cell Biology.
Pickett SB, Raible DW.
J Assoc Res Otolaryngol. 2019 Feb; 1(20)1-19
Pickett SB, Thomas ED, Sebe JY, Linbo T, Esterberg R, Hailey DW, Raible DW.
Elife. 2018 Dec 31; (7)
The role of retrograde intraflagellar transport genes in aminoglycoside-induced hair cell death.
Stawicki TM, Linbo T, Hernandez L, Parkinson L, Bellefeuille D, Rubel EW, Raible DW.
Biol Open. 2019 Jan 14; 1(8)
Ryals M, Morell RJ, Martin D, Boger ET, Wu P, Raible DW, Cunningham LL.
Front Cell Neurosci. 2018; (12)445
Noise-Induced Hypersensitization of the Acoustic Startle Response in Larval Zebrafish.
Bhandiwad AA, Raible DW, Rubel EW, Sisneros JA.
J Assoc Res Otolaryngol. 2018 Dec; 6(19)741-752
De novo variants in GREB1L are associated with non-syndromic inner ear malformations and deafness.
Schrauwen I, Kari E, Mattox J, Llaci L, Smeeton J, Naymik M, Raible DW, Knowles JA, Crump JG, Huentelman MJ, Friedman RA.
Hum Genet. 2018 Jul; 6-7(137)459-470
Chowdhury S, Owens KN, Herr RJ, Jiang Q, Chen X, Johnson G, Groppi VE, Raible DW, Rubel EW, Simon JA.
J Med Chem. 2018 Jan 11; 1(61)84-97
Gau P, Curtright A, Condon L, Raible DW, Dhaka A.
PLoS Genet. 2017 Jul; 7(13)e1006884
Sebe JY, Cho S, Sheets L, Rutherford MA, von Gersdorff H, Raible DW.
J Neurosci. 2017 Jun 21; 25(37)6162-6175
Aose M, Linbo TH, Lawrence O, Senoo T, Raible DW, Clark JI.
Dev Dyn. 2017 Nov; 11(246)915-924
Fluorescent aminoglycosides reveal intracellular trafficking routes in mechanosensory hair cells.
Hailey DW, Esterberg R, Linbo TH, Rubel EW, Raible DW.
J Clin Invest. 2017 Feb 1; 2(127)472-486
Defective adgra2 (gpr124) splicing and function in zebrafish ouchless mutants.
Bostaille N, Gauquier A, Stainier DY, Raible DW, Vanhollebeke B.
Development. 2017 Jan 1; 1(144)8-11
Mitochondrial calcium uptake underlies ROS generation during aminoglycoside-induced hair cell death.
Esterberg R, Linbo T, Pickett SB, Wu P, Ou HC, Rubel EW, Raible DW.
J Clin Invest. 2016 Sep 1; 9(126)3556-66
Cilia-Associated Genes Play Differing Roles in Aminoglycoside-Induced Hair Cell Death in Zebrafish.
Stawicki TM, Hernandez L, Esterberg R, Linbo T, Owens KN, Shah AN, Thapa N, Roberts B, Moens CB, Rubel EW, Raible DW.
G3 (Bethesda). 2016 Jul 7; 7(6)2225-35
Innervation regulates synaptic ribbons in lateral line mechanosensory hair cells.
Suli A, Pujol R, Cunningham DE, Hailey DW, Prendergast A, Rubel EW, Raible DW.
J Cell Sci. 2016 Jun 1; 11(129)2250-60
Reck enables cerebrovascular development by promoting canonical Wnt signaling.
Ulrich F, Carretero-Ortega J, Menéndez J, Narvaez C, Sun B, Lancaster E, Pershad V, Trzaska S, Véliz E, Kamei M, Prendergast A, Kidd KR, Shaw KM, Castranova DA, Pham VN, Lo BD, Martin BL, Raible DW, Weinstein BM, Torres-Vázquez J.
Development. 2016 Mar 15; 6(143)1055
Yoshimatsu T, D'Orazi FD, Gamlin CR, Suzuki SC, Suli A, Kimelman D, Raible DW, Wong RO.
Nat Commun. 2016 Feb 3; (7)10590
Reck enables cerebrovascular development by promoting canonical Wnt signaling.
Ulrich F, Carretero-Ortega J, Menéndez J, Narvaez C, Sun B, Lancaster E, Pershad V, Trzaska S, Véliz E, Kamei M, Prendergast A, Kidd KR, Shaw KM, Castranova DA, Pham VN, Lo BD, Martin BL, Raible DW, Weinstein BM, Torres-Vázquez J.
Development. 2016 Jan 1; 1(143)147-59
Cruz IA, Kappedal R, Mackenzie SM, Hailey DW, Hoffman TL, Schilling TF, Raible DW.
Dev Biol. 2015 Jun 15; 2(402)229-38
Stawicki TM, Esterberg R, Hailey DW, Raible DW, Rubel EW.
Front Cell Neurosci. 2015; (9)46
Thomas AJ, Wu P, Raible DW, Rubel EW, Simon JA, Ou HC.
Otol Neurotol. 2015 Mar; 3(36)519-25
Modeling nociception in zebrafish: a way forward for unbiased analgesic discovery.
Curtright A, Rosser M, Goh S, Keown B, Wagner E, Sharifi J, Raible DW, Dhaka A.
PLoS One. 2015; 1(10)e0116766
There and back again: development and regeneration of the zebrafish lateral line system.
Thomas ED, Cruz IA, Hailey DW, Raible DW.
Wiley Interdiscip Rev Dev Biol. 2015 Jan-Feb; 1(4)1-16
ER-mitochondrial calcium flow underlies vulnerability of mechanosensory hair cells to damage.
Esterberg R, Hailey DW, Rubel EW, Raible DW.
J Neurosci. 2014 Jul 16; 29(34)9703-19
Stawicki TM, Owens KN, Linbo T, Reinhart KE, Rubel EW, Raible DW.
Dis Model Mech. 2014 Jul; 7(7)847-56
Suli A, Guler AD, Raible DW, Kimelman D.
Development. 2014 Mar; 5(141)1167-74
Fish in a Dish: Drug Discovery for Hearing Habilitation.
Esterberg R, Coffin AB, Ou H, Simon JA, Raible DW, Rubel EW.
Drug Discov Today Dis Models. 2013; 1(10)
Modulation of dorsal root ganglion development by ErbB signaling and the scaffold protein Sorbs3.
Malmquist SJ, Abramsson A, McGraw HF, Linbo TH, Raible DW.
Development. 2013 Oct; 19(140)3986-96
Bhandiwad AA, Zeddies DG, Raible DW, Rubel EW, Sisneros JA.
J Exp Biol. 2013 Sep 15; Pt 18(216)3504-13
Coffin AB, Rubel EW, Raible DW.
J Assoc Res Otolaryngol. 2013 Oct; 5(14)645-59
Esterberg R, Hailey DW, Coffin AB, Raible DW, Rubel EW.
J Neurosci. 2013 Apr 24; 17(33)7513-25
The zebrafish ortholog of TRPV1 is required for heat-induced locomotion.
Gau P, Poon J, Ufret-Vincenty C, Snelson CD, Gordon SE, Raible DW, Dhaka A.
J Neurosci. 2013 Mar 20; 12(33)5249-60
Thomas AJ, Hailey DW, Stawicki TM, Wu P, Coffin AB, Rubel EW, Raible DW, Simon JA, Ou HC.
J Neurosci. 2013 Mar 6; 10(33)4405-14
Profiling drug-induced cell death pathways in the zebrafish lateral line.
Coffin AB, Williamson KL, Mamiya A, Raible DW, Rubel EW.
Apoptosis. 2013 Apr; 4(18)393-408
Proliferative regeneration of zebrafish lateral line hair cells after different ototoxic insults.
Mackenzie SM, Raible DW.
PLoS One. 2012; 10(7)e47257
Hailey DW, Roberts B, Owens KN, Stewart AK, Linbo T, Pujol R, Alper SL, Rubel EW, Raible DW.
PLoS Genet. 2012; 10(8)e1002971
Ou HC, Keating S, Wu P, Simon JA, Raible DW, Rubel EW.
J Assoc Res Otolaryngol. 2012 Dec; 6(13)759-70
Vlasits AL, Simon JA, Raible DW, Rubel EW, Owens KN.
Hear Res. 2012 Dec; 1-2(294)153-65
Postembryonic neuronal addition in zebrafish dorsal root ganglia is regulated by Notch signaling.
McGraw HF, Snelson CD, Prendergast A, Suli A, Raible DW.
Neural Dev. 2012 Jun 27; (7)23
Specification of neural crest into sensory neuron and melanocyte lineages.
Pavan WJ, Raible DW.
Dev Biol. 2012 Jun 1; 1(366)55-63
Identification of modulators of hair cell regeneration in the zebrafish lateral line.
Namdaran P, Reinhart KE, Owens KN, Raible DW, Rubel EW.
J Neurosci. 2012 Mar 7; 10(32)3516-28
Rheotaxis in larval zebrafish is mediated by lateral line mechanosensory hair cells.
Suli A, Watson GM, Rubel EW, Raible DW.
PLoS One. 2012; 2(7)e29727
Screening for chemicals that affect hair cell death and survival in the zebrafish lateral line.
Ou H, Simon JA, Rubel EW, Raible DW.
Hear Res. 2012 Jun; 1-2(288)58-66
The metalloproteinase inhibitor Reck is essential for zebrafish DRG development.
Prendergast A, Linbo TH, Swarts T, Ungos JM, McGraw HF, Krispin S, Weinstein BM, Raible DW.
Development. 2012 Mar; 6(139)1141-52
Lef1 is required for progenitor cell identity in the zebrafish lateral line primordium.
McGraw HF, Drerup CM, Culbertson MD, Linbo T, Raible DW, Nechiporuk AV.
Development. 2011 Sep; 18(138)3921-30
A feast for the senses: development and function of sensory systems.
Streit A, Raible DW.
EMBO Rep. 2011 Sep 1; 9(12)874-6
Patterning the nervous system through development and evolution.
Ghysen A, Dambly-Chaudière C, Raible DW.
Int J Dev Biol. 2010; 10(54)S1-S14
Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest.
Curran K, Lister JA, Kunkel GR, Prendergast A, Parichy DM, Raible DW.
Dev Biol. 2010 Aug 1; 1(344)107-18
UDP xylose synthase 1 is required for morphogenesis and histogenesis of the craniofacial skeleton.
Eames BF, Singer A, Smith GA, Wood ZA, Yan YL, He X, Polizzi SJ, Catchen JM, Rodriguez-Mari A, Linbo T, Raible DW, Postlethwait JH.
Dev Biol. 2010 May 15; 2(341)400-15
Chemical screening for hair cell loss and protection in the zebrafish lateral line.
Coffin AB, Ou H, Owens KN, Santos F, Simon JA, Rubel EW, Raible DW.
Zebrafish. 2010 Mar; 1(7)3-11
Ou HC, Santos F, Raible DW, Simon JA, Rubel EW.
Drug Discov Today. 2010 Apr; 7-8(15)265-71
Foxd3 controls melanophore specification in the zebrafish neural crest by regulation of Mitf.
Curran K, Raible DW, Lister JA.
Dev Biol. 2009 Aug 15; 2(332)408-17
Signaling pathways regulating zebrafish lateral line development.
Ma EY, Raible DW.
Curr Biol. 2009 May 12; 9(19)R381-6
Kit and foxd3 genetically interact to regulate melanophore survival in zebrafish.
Cooper CD, Linbo TH, Raible DW.
Dev Dyn. 2009 Apr; 4(238)875-86
Coffin AB, Reinhart KE, Owens KN, Raible DW, Rubel EW.
Hear Res. 2009 Jul; 1-2(253)42-51
Owens KN, Coffin AB, Hong LS, Bennett KO, Rubel EW, Raible DW.
Hear Res. 2009 Jul; 1-2(253)32-41
Feathers and fins: non-mammalian models for hair cell regeneration.
Brignull HR, Raible DW, Stone JS.
Brain Res. 2009 Jun 24; (1277)12-23
Ou HC, Cunningham LL, Francis SP, Brandon CS, Simon JA, Raible DW, Rubel EW.
J Assoc Res Otolaryngol. 2009 Jun; 2(10)191-203
McGraw HF, Nechiporuk A, Raible DW.
J Neurosci. 2008 Nov 19; 47(28)12558-69
Gorden NT, Arts HH, Parisi MA, Coene KL, Letteboer SJ, van Beersum SE, Mans DA, Hikida A, Eckert M, Knutzen D, Alswaid AF, Ozyurek H, Dibooglu S, Otto EA, Liu Y, Davis EE, Hutter CM, Bammler TK, Farin FM, Dorschner M, Topçu M, Zackai EH, Rosenthal P, Owens KN, Katsanis N, Vincent JB, Hildebrandt F, Rubel EW, Raible DW, Knoers NV, Chance PF, Roepman R, Moens CB, Glass IA, Doherty D.
Am J Hum Genet. 2008 Nov; 5(83)559-71
Mechanisms for reaching the differentiated state: Insights from neural crest-derived melanocytes.
Cooper CD, Raible DW.
Semin Cell Dev Biol. 2009 Feb; 1(20)105-10
FGF-dependent mechanosensory organ patterning in zebrafish.
Nechiporuk A, Raible DW.
Science. 2008 Jun 27; 5884(320)1774-7
Identification of genetic and chemical modulators of zebrafish mechanosensory hair cell death.
Owens KN, Santos F, Roberts B, Linbo T, Coffin AB, Knisely AJ, Simon JA, Rubel EW, Raible DW.
PLoS Genet. 2008 Feb 29; 2(4)e1000020
Using the zebrafish lateral line to screen for ototoxicity.
Chiu LL, Cunningham LL, Raible DW, Rubel EW, Ou HC.
J Assoc Res Otolaryngol. 2008 Jun; 2(9)178-90
Notch signaling regulates the extent of hair cell regeneration in the zebrafish lateral line.
Ma EY, Rubel EW, Raible DW.
J Neurosci. 2008 Feb 27; 9(28)2261-73
Cisplatin-induced hair cell loss in zebrafish (Danio rerio) lateral line.
Ou HC, Raible DW, Rubel EW.
Hear Res. 2007 Nov; 1-2(233)46-53
Owens KN, Cunningham DE, MacDonald G, Rubel EW, Raible DW, Pujol R.
J Comp Neurol. 2007 Jun 1; 4(502)522-43
Specification of epibranchial placodes in zebrafish.
Nechiporuk A, Linbo T, Poss KD, Raible DW.
Development. 2007 Feb; 3(134)611-23
Specification of sensory neuron cell fate from the neural crest.
Raible DW, Ungos JM.
Adv Exp Med Biol. 2006; (589)170-80
Development of the neural crest: achieving specificity in regulatory pathways.
Raible DW
Curr Opin Cell Biol. 2006 Dec; 6(18)698-703
Urban AE, Zhou X, Ungos JM, Raible DW, Altmann CR, Vize PD.
Dev Biol. 2006 Sep 1; 1(297)103-17
Santos F, MacDonald G, Rubel EW, Raible DW.
Hear Res. 2006 Mar; 1-2(213)25-33
lessen encodes a zebrafish trap100 required for enteric nervous system development.
Pietsch J, Delalande JM, Jakaitis B, Stensby JD, Dohle S, Talbot WS, Raible DW, Shepherd IT.
Development. 2006 Feb; 3(133)395-406
Zebrafish Foxd3 is required for development of a subset of neural crest derivatives.
Lister JA, Cooper C, Nguyen K, Modrell M, Grant K, Raible DW.
Dev Biol. 2006 Feb 1; 1(290)92-104
Nechiporuk A, Linbo T, Raible DW.
Development. 2005 Aug; 16(132)3717-30
Reiterated Wnt and BMP signals in neural crest development.
Raible DW, Ragland JW.
Semin Cell Dev Biol. 2005 Dec; 6(16)673-82
Sagasti A, Guido MR, Raible DW, Schier AF.
Curr Biol. 2005 May 10; 9(15)804-14
Regulation of latent sensory hair cell precursors by glia in the zebrafish lateral line.
Grant KA, Raible DW, Piotrowski T.
Neuron. 2005 Jan 6; 1(45)69-80
Signals derived from the underlying mesoderm are dispensable for zebrafish neural crest induction.
Ragland JW, Raible DW.
Dev Biol. 2004 Dec 1; 1(276)16-30
Reiterated Wnt signaling during zebrafish neural crest development.
Lewis JL, Bonner J, Modrell M, Ragland JW, Moon RT, Dorsky RI, Raible DW.
Development. 2004 Mar; 6(131)1299-308
Roles for GFRalpha1 receptors in zebrafish enteric nervous system development.
Shepherd IT, Pietsch J, Elworthy S, Kelsh RN, Raible DW.
Development. 2004 Jan; 1(131)241-9
Murakami SL, Cunningham LL, Werner LA, Bauer E, Pujol R, Raible DW, Rubel EW.
Hear Res. 2003 Dec; 1-2(186)47-56
Ungos JM, Karlstrom RO, Raible DW.
Development. 2003 Nov; 22(130)5351-62
Harris JA, Cheng AG, Cunningham LL, MacDonald G, Raible DW, Rubel EW.
J Assoc Res Otolaryngol. 2003 Jun; 2(4)219-34
Elworthy S, Lister JA, Carney TJ, Raible DW, Kelsh RN.
Development. 2003 Jun; 12(130)2809-18
Neurogenin1 defines zebrafish cranial sensory ganglia precursors.
Andermann P, Ungos J, Raible DW.
Dev Biol. 2002 Nov 1; 1(251)45-58
Specification of zebrafish neural crest.
Kelsh RN, Raible DW.
Results Probl Cell Differ. 2002; (40)216-36
Lister JA, Close J, Raible DW.
Dev Biol. 2001 Sep 15; 2(237)333-44
Functional analysis of zebrafish GDNF.
Shepherd IT, Beattie CE, Raible DW.
Dev Biol. 2001 Mar 15; 2(231)420-35
Environmental signals and cell fate specification in premigratory neural crest.
Dorsky RI, Moon RT, Raible DW.
Bioessays. 2000 Aug; 8(22)708-16
Organization of the lateral line system in embryonic zebrafish.
Raible DW, Kruse GJ.
J Comp Neurol. 2000 May 29; 2(421)189-98
Dorsky RI, Raible DW, Moon RT.
Genes Dev. 2000 Jan 15; 2(14)158-62
Maternal and embryonic expression of zebrafish lef1.
Dorsky RI, Snyder A, Cretekos CJ, Grunwald DJ, Geisler R, Haffter P, Moon RT, Raible DW.
Mech Dev. 1999 Aug; 1-2(86)147-50
Lister JA, Robertson CP, Lepage T, Johnson SL, Raible DW.
Development. 1999 Sep; 17(126)3757-67
Beattie CE, Raible DW, Henion PD, Eisen JS.
Methods Cell Biol. 1999; (60)71-86
Control of neural crest cell fate by the Wnt signalling pathway.
Dorsky RI, Moon RT, Raible DW.
Nature. 1998 Nov 26; 6709(396)370-3
Expression of c-ret in the zebrafish embryo: potential roles in motoneuronal development.
Bisgrove BW, Raible DW, Walter V, Eisen JS, Grunwald DJ.
J Neurobiol. 1997 Nov 20; 6(33)749-68
Regulative interactions in zebrafish neural crest.
Raible DW, Eisen JS.
Development. 1996 Feb; 2(122)501-7
Screen for mutations affecting development of Zebrafish neural crest.
Henion PD, Raible DW, Beattie CE, Stoesser KL, Weston JA, Eisen JS.
Dev Genet. 1996; 1(18)11-7
Lateral specification of cell fate during vertebrate development.
Raible DW, Eisen JS.
Curr Opin Genet Dev. 1995 Aug; 4(5)444-9
Rin, a novel cell-surface protein that labels reticular neurons early in chick neurogenesis.
Chang S, Raible DW.
J Neurobiol. 1994 Apr; 4(25)395-405
Restriction of neural crest cell fate in the trunk of the embryonic zebrafish.
Raible DW, Eisen JS.
Development. 1994 Mar; 3(120)495-503
Raible DW, McMorris FA.
J Neurosci Res. 1993 Feb 15; 3(34)287-94
Segregation and early dispersal of neural crest cells in the embryonic zebrafish.
Raible DW, Wood A, Hodsdon W, Henion PD, Weston JA, Eisen JS.
Dev Dyn. 1992 Sep; 1(195)29-42
Induction of oligodendrocyte differentiation by activators of adenylate cyclase.
Raible DW, McMorris FA.
J Neurosci Res. 1990 Sep; 1(27)43-6
Regulation of oligodendrocyte development by insulin-like growth factors and cyclic nucleotides.
McMorris FA, Furlanetto RW, Mozell RL, Carson MJ, Raible DW.
Ann N Y Acad Sci. 1990; (605)101-9
Raible DW, McMorris FA.
Dev Biol. 1989 Jun; 2(133)437-46
Bernier L, Alvarez F, Norgard EM, Raible DW, Mentaberry A, Schembri JG, Sabatini DD, Colman DR.
J Neurosci. 1987 Sep; 9(7)2703-10
Research Summary
Hair cells of the inner ear conver mechanical stimuli to electrical signals transmitted to the brain. Damage and loss of hair cells are leading causes of hearing and balance disorders, affecting over 40 million people in the US. Hair cell loss in humans is irreversible, however they regenerate in other species. We use the zebrafish to study hair cell development, death and regeneration using genetics, genome editing, high resolution imaging and small molecule screening.